Hubungan antara Kadar Feritin dengan Malondialdehyde pada Pasien Talasemia β Mayor di RSD dr. Soebandi Jember

Abstract

Repeated blood transfusions, increased iron absorption, and ineffective erythropoiesis in major β thalassemia patients lead to iron overload characterized by elevated ferritin levels. Free iron will catalyze reactive oxygen species (ROS) formation by Fenton reaction that cause oxidative stress. Malondialdehyde (MDA) is the lipid peroxidation end product used to measure the oxidative stress. This study aimed to determine the correlation between ferritin levels and MDA levels in major β thalassemia patients at dr. Soebandi Hospital Jember. An analitic observational study with cross sectional study design which the subjects were 15 patients with major β thalassemia in the Pediatric Department at dr. Soebandi Hospital Jember who met inclusion and exclusion criteria. Ferritin levels measured by Enzyme-Linked Fluorescent Immuno Assay (ELFA) method and MDA levels measured by Thiobarbituric Acid Reactive Substances (TBARS) method using spectrophotometer at 535 nm. Data was analyzed with Shapiro Wilk normality test and Pearson correlation test. The mean of ferritin levels was 3540,46±3925,37 ng/mL and MDA levels was 4,77±2,03 nmol/mL. The result showed that there is strong positive correlation between ferritin levels and MDA levels with p value=0,001 and r=0,786 in major β thalassemia patients at dr. Soebandi Hospital Jember.

Karakteristik Pasien Glioma di RSUD Ulin Banjarmasin Tahun 2018-2020

“…8 Di Indonesia, glioma merupakan tumor otak primer yang paling sering ditemukan. 9 Di RSUP Sanglah Denpasar Bali data menunjukkan dari tahun 2014 -2018 terdapat 84 pasien menderita tumor Glia dengan persentase kejadian tertinggi pada kelompok data umur dengan rentang 31-40 tahun sebesar 23,8%(n=20) dan berdasarkan jenis kelamin pada Laki-laki sebanyak 60,7%(n=51). 3 Di RSUP dr. Kariadi Semarang data menunjukkan dari tahun 2015-2018 terdapat 175 pasien menderita tumor otak primer dimana 56 diantaranya diklasifikasikan sebagai glioma dengan jumlah kejadian tinggi dipegang oleh kedua kelompok umur yaitu rentang 41-50 tahun sebanyak 18 orang dan rentang 51-60 sebanyak 17 orang.…”

Antioxidant Activity of Sappan Wood Extract (Caesalpinia sappan L.) As An Adjuvant and Substitution in Blood Serum of Rats (Rattus norvegicus) Iron Overload Model

“…Long-term oxidative stress has been shown to cause various degenerative diseases. One of the indicators used to determine oxidative stress in humans is the level of malondialdehyde (MDA) which is the result of lipid peroxidation in the body due to free radicals [3].…”