Hubungan asupan serat dengan angka kejadian kanker kolorektal di RSUP Sanglah Denpasar tahun 2016 - 2017

Abstract

Background: Colorectal cancer is one of the most common cancer in Indonesia. The etiology of colorectal cancer is still unknown, but many risk factors believed may causing colorectal cancer, one of them is fiber intake of foods consumed every day like vegetables, fruits, and peanuts. There is an instrument that can be used to assess fiber intake per day. Aim: The study aimed to know how the correlation between fiber intake and colorectal cancer patient are in Sanglah General Hospital. Method: The design is a case-control analytic study, obtained total of 104 samples that divided into case group (52 samples) and control group (52 samples), in which secondary data with medical record data and also primary data with questionnaire are collected. Data were analyzed using the SPSS program. Result: Of the 104 samples that divided into case group and control group with 1:1 ratio, patients who diagnosed with colorectal cancer had a history of low fiber intake higher 6.75 times than peoples who not diagnosed with colorectal cancer (OR=6.75; 95% CI 2.85-15.96; P<0.001). Conclusion: Patients who diagnosed with colorectal cancer had a history of low fiber intake per day higher 6.75 times than samples which did not diagnose with colorectal cancer.

Dietary management in colorectal cancer prevention: a review

“…Studies have shown that regular consumption of fruits and vegetables is associated with a reduced incidence of chronic diseases, including cancer. 33,34 An 18-year cohort study reported that consumption of four or more servings of legumes per week had a lower incidence of colorectal adenoma than consumption of one or less servings per week. 35 These results still need attention, especially the average intake of participants is 16.7 grams / day and is below the recommended average intake of 30-40 grams / day.…”

THE ASSOCIATION BETWEEN B-RAF V600E GENE MUTATION WITH AGE, GRADING, AND CLINICAL RESPONSE IN COLORECTAL CANCER AT THE CENTER GENERAL HOSPITAL (RSUP) PROF. Dr. I GOESTI NGOERAH GDE NGOERAH IN BALI

“…This is caused by the content of fiber, PUFA, polyphenols, and vitamins, which have a role in preventing colorectal carcinogenesis. (Swari et al, 2019) CRC develops through several genetic and epigenetic pathways. These pathways are defined on the basis of three molecular features: (i) mutations in DNA mismatch repair genes, leading to a DNA phenotype of microsatellite instability (MSI); (ii) mutations in APC and other genes that activate the Wnt pathway, marked by a chromosomal instability (CIN) phenotype, and (iii) global genome hypermethylation, resulting in the turn-off of tumor suppressor genes, which was shown to be the CpG island methylator phenotype (CIMP).…”