Hubungan Bayi Berat Lahir Rendah (BBLR) dengan kejadian hiperbilirubinemia pada neonatus di RSUD Wangaya, Bali, Indonesia

Yasadipura, Conchita Christal; Suryawan, I Wayan Bikin; Sucipta, Anak Agung Made

doi:10.15562/ism.v11i3.706

Cited by 4 publications

(9 citation statements)

References 6 publications

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“…11 Males neonates were also the most affected by hyperbilirubinemia (53%) in a study conducted by Yasadipura (2020). 12 Most of the neonates with hyperbilirubinemia in this study were born by spontaneous delivery -noninstrumental/caesarian deliveries (50.8%). This was in line with the observations of a 2017 study conducted by Rohani et al comparing the neonates delivered spontaneously (54.3%) and other neonates who had a cesarean section, vacuum, or forceps (45.7%) deliveries.…”

Section: Discussionmentioning

confidence: 76%

“…Yasadipura et al (2020) also supported this finding, as they discovered a higher prevalence of hyperbilirubinemia in neonates whose mothers had no history of the maternal disease (54%). 12 Table 2 revealed that 33 (55.9%) of the 59 neonates with hyperbilirubinemia had full-term gestational age at Wangaya Hospital in Denpasar. Hyperbilirubinemia was more common in preterm neonates, occurring in 22.7% of full-term neonates and 53% of preterm neonates.…”

Section: Discussionmentioning

confidence: 99%

“…This finding was consistent with Faiqah et al ( 2014), which discovered that of 195 neonates higher incidence of hyperbilirubinemia in preterm neonates (34.7%) vs. 18.6% in full-term neonates. 12 Based on birth weight, it was known that the majority of neonates with hyperbilirubinemia had normal birth weight (50.8%). The incidence of hyperbilirubinemia in neonates with LBW was 44.6% (n=29), while the incidence of hyperbilirubinemia in neonates who were not LBW was 23.2% (n=30) out of 129 participants who had no LBW.…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with the incidence of neonatal hyperbilirubinemia in Perinatology Ward of Wangaya General Hospital, Denpasar

Melinda¹,

Suryawan²,

Sucipta³

2021

Bali Med J.

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Background: Hyperbilirubinemia is a condition defined by an increased total serum bilirubin level exceeding 5 mg/dL and clinically characterized by the presence of jaundice. Jaundice can be observed on the skin and sclera if the bilirubin level increases more than 5 mg/dL. Several risk factors, including birth weight, asphyxia, gestational age, mode of delivery, and breastfeeding practices, have been studied regarding their relationship to the incidence of hyperbilirubinemia, with varying results. Therefore, the purpose of this study was to determine the relationship between these risk factors and the incidence of hyperbilirubinemia.Methods: An analytical observational cross-sectional study was conducted by collecting secondary data from the Perinatology Ward registry and the medical records department. The subjects were neonates treated in the Perinatology Ward of Wangaya Hospital, Denpasar. The data that met the inclusion and exclusion criteria were then analyzed with the SPSS 25.Results: There were 59 neonates with hyperbilirubinemia and 135 neonates without hyperbilirubinemia among the 194 research subjects. The results of the chi-square test were the following: p-value for birth weight = 0.002, p-value for asphyxia = 0.002, p value for breastfeeding practice = 0.003, p value for gestational age = 0.000, and p value for delivery mode = 0.110.Conclusion: There was a significant relationship between birth weight, asphyxia, gestational age, breastfeeding practices, and the incidence of neonatal hyperbilirubinemia in the Perinatology Ward, Wangaya Hospital, Denpasar City. Meanwhile, no relationship was observed between the mode of delivery and newborn hyperbilirubinemia.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Factors associated with the incidence of neonatal hyperbilirubinemia in Perinatology Ward of Wangaya General Hospital, Denpasar

Melinda¹,

Suryawan²,

Sucipta³

2021

Bali Med J.

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“…Penyebab lainnya ialah karena terjadinya peningkatan hemolisis pada bayi sehingga terjadi penumpukan bilirubin indirek di dalam darah. 6,7 Faktor prematuritas pada bayi merupakan salah satu penyebab terjadinya hiperbilirubinemia. Organ dalam tubuh bayi masih belum berkembang dan berfungsi dengan baik.…”

Section: Bahasanunclassified

“…Asfiksia dapat menyebabkan asidosis, yaitu pH darah <7, yang dapat menyebabkan gangguan transportasi dan konjugasi bilirubin sehingga terjadi penumpukan bilirubin dan bermanifestasi kuning pada kulit. 11 Penelitian oleh Yasadipura et al 7 melaporkan terdapatnya hubungan antara BBLR dengan kejadian hiperbilirubinemia pada bayi baru lahir di RS Wangaya (p=0,042) dengan rasio prevalensi 2,13 yang menyiratkan bahwa BBLR merupakan faktor risiko kejadian hiperbilirubinemia. Salah satu penyebab kejadian hiperbilirubinemia pada BBLR yaitu imaturitas hati yang berakibat terhambatnya proses konjugasi dari bilirubin indirek ke direk sehingga terjadi ikterus.…”

Section: Bahasanunclassified

Mekanisme Terjadinya Hiperbilirubinemia pada Bayi Berat Lahir Rendah

Gerungan

Wilar

Mantik

2022

eCL

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Hyperbilirubinemia is frequently found in newborns, especially in low birth weight (LBW) infants (less than 2,500 g). Hyperbilirubinemia is an increase in bilirubin higher than 5 mg/dL which clinically manifests as icterus. This study aimed to evaluate the relationship between LBW and the incidence of hyperbilirubinemia as well as the underlying mechanism. This was a literature study. Article searching used databases of Pubmed and Google Schoolar and the keywords were Hyperbilirubinemia AND Low birth weight NAD Neonatal Jaundice. The results showed a relationship between LBW and the incidence of hyperbilirubinemia. There were increases of hemoglobin, heme catabolism, and destruction of bilirubin due to liver immaturity, impaired liver function and perfusion and bilirubin conjugation ability, less of albumin as the transportation protein and uridine diphosphate glucuronyltransferase (UDP-GT) to convert indirect bilirubin to direct bilirubin in the liver. In conclusion, there is a relationship between low birth weight and hyperbilirubinemia that occurs due to liver immaturity, impaired liver function and perfusion, and less of albumin and UDP-GT enzyme. Keywords: hyperbilirubinemia; low birth weight; neonatal jaundice Abstrak: Hiperbilirubinemia merupakan masalah yang sering terjadi pada bayi baru lahir terlebih bayi dengan berat lahir rendah (<2.500 gram). Hiperbilirubinemia merupakan peningkatan kadar bilirubin serum >5mg/dL yang bermanifestasi klinis berupa ikterus. Penelitian ini bertujuan untuk mengetahui hubungan antara BBLR dengan kejadian hiperbilirubinemia dan mekanisme terjadinya. Jenis penelitian ialah suatu literature review. Pencarian artikel menggunakan Pubmed dan Google Schoolar dengan kata kunci Hyperbilirubinemia AND Low birth weight AND Neonatal Jaundice. Hasil penelitian mendapatkan adanya hubungan antara BBLR dengan kejadian hiperbilirubinemia. Terdapat peningkatan jumlah hemoglobin, katabolisme heme dan penghan-curan bilirubin yang terjadi antara lain karena imaturitas hati yang belum optimal mengkonju-gasikan bilirubin, terganggunya fungsi dan perfusi hati serta kemampuan mengkonjugasi bilirubin, rendahnya kadar protein albumin sebagai transportasi dan enzim uridin difosfat glukoronid transferase (UDP-GT) untuk mengonversi bilirubin indirek menjadi bilirubin direk di dalam hati. Simpulan penelitian ini ialah terdapat hubungan antara BBLR dengan hiperbilirubinemia yang dapat terjadi karena imaturitas hati, terganggunya fungsi dan perfusi hati, serta kurangnya protein albumin dan enzim UDP-GT. Kata kunci: hiperbilirubinemia; low birth weight; neonatal jaundice

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Gambaran Faktor Risiko Hiperbilirubinemia Pada Neonatus yang Dirawat di Ruang Perinatologi RSUP Dr. M. Djamil Padang

Fadhillah,

Afdal,

Pertiwi

et al. 2024

JIKESI

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Abstrak Latar Belakang: Hiperbilirubinemia ditandai dengan adanya ikterus. Hiperbilirubinemia dibedakan menjadi dua jenis, yaitu hiperbilirubinemia fisiologis dan patologis. Hiperbilirubinemia pada neonatus perlu mendapat perhatian karena dapat menyebabkan neonatus mengalami bilirubin ensefalopati akut atau pada fase lanjut akan menyebabkan kernikterus Objektif: Penelitian ini bertujuan untuk mengetahui gambaran faktor risiko hiperbilirubinemia pada neonatus yang dirawat di perinatologi RSUP Dr. M. Djamil Padang Metode: Penelitian ini merupakan penelitian deskriptif retrospektif yang menggunakan data rekam medis neonatus dengan hiperbilirubinemia pada bulan Januari 2021 hingga Desember 2022 Hasil: Hasil penelitian ini didapatkan 58,6% neonatus dengan hiperbilirubinemia berjenis kelamin laki-laki, dan 35,7% masuk dalam kategori high risk. Kejadian faktor risiko hiperbilrubinemia pada neonatus adalah 35,6% dengan berat lahir rendah, 32,8% dengan inkompatibilitas darah, 32,8% dengan preterm, 21,4% dengan infeksi, 7,1% dengan breastfeeding jaundice, dan 1,4% dengan ibu diabetes melitus. Tidak ditemukan faktor risiko polisitemia pada neonatus yang hiperbilirubinemia. Kesimpulan. Pada penelitian ini didapatkan faktor risiko hiperbilirubinemia pada neonatus terbanyak adalah BBLR, diikuti oleh faktor risiko lainnya seperti inkompatibilitas darah, usia gestasi, infeksi, breastfeeding jaundice, dan ibu diabetes melitus Abstract Background: Hyperbilirubinemia is an increased level of bilirubin in the blood which is clinically characterized by icterus. There are various risk factors for hyperbilirubinemia in neonates so attention needs to be paid because it can cause neonates to experience acute bilirubin encephalopathy or in the advanced phase it can cause kernicterus. Objective: This study aims to describe the risk factors for hyperbilirubinemia in neonates treated at the neonatology department of RSUP Dr. M. Djamil Padang. Method: This research is a retrospective descriptive study using medical records of neonates with hyperbilirubinemia. This research was conducted at RSUP Dr. M. Djamil Padang in January 2021 – December 2022. In this study, 70 samples were obtained from neonates with a diagnosis of hyperbilirubinemia who met the inclusion criteria. Result: The results of this study founded that 35,7% of neonates with hyperbilirubinemia were included in the high risk category. 41% of neonates with hyperbilirubinemia are male. The risk factors for hyperbilirubinemia in neonates were 35.6% with low birth weight neonates, 32.8% with blood incompatibility, 32.8% with preterm, 21.4% with infections, 7.1% with breastfeeding jaundice, and 1.4% with diabetes mellitus. No risk factors for polycythemia were found in neonates with hyperbilirubinemia. Conclusion: The conclusion of this study is the most common risk factor for hyperbilirubinemia in neonates is LBW, followed by other risk factors such as blood incompatibility, gestational age, infection, breastfeeding jaundice, cholestasis, and maternal diabetes mellitus. Keyword: Neonates, hyperbilirubinemia, risk factors.

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Hubungan Bayi Berat Lahir Rendah (BBLR) dengan kejadian hiperbilirubinemia pada neonatus di RSUD Wangaya, Bali, Indonesia

Cited by 4 publications

References 6 publications

Factors associated with the incidence of neonatal hyperbilirubinemia in Perinatology Ward of Wangaya General Hospital, Denpasar

Factors associated with the incidence of neonatal hyperbilirubinemia in Perinatology Ward of Wangaya General Hospital, Denpasar

Mekanisme Terjadinya Hiperbilirubinemia pada Bayi Berat Lahir Rendah

Gambaran Faktor Risiko Hiperbilirubinemia Pada Neonatus yang Dirawat di Ruang Perinatologi RSUP Dr. M. Djamil Padang

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