Hubungan Derajat Kolesteatoma dengan Keberhasilan Mastoidektomi Radikal pada Otitis Media Supuratif Kronis dengan Kolesteatoma

Handoko, Edi; Indrasworo, Dyah; Nursalim, Akhmad Harun

doi:10.32637/orli.v49i20.302

Cited by 1 publication

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic suppurative otitis media (CSOM) is a chronic middle ear infection characterized by a history of continuous ear discharge from the middle ear through the perforated tympanic membrane [1], [2], [3]. Secretions in OMSK either disappear or occur continuously for more than 2 months [4]. The prevalence of CSOM in the world is 65-330 million people, especially in developing countries.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression of CCL27 in Middle Ear Cholesteatoma

Edward

Decroli

Ali

et al. 2021

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Cholesteatoma is a lesion of the temporal bone lined by stratified squamous epithelium that contains desquamated keratin. Cholesteatoma is considered more aggressive during childhood. The molecular mechanism of the pathogenesis of cholesteatoma formation is still unclear. Previous studies reported on immunohistochemical examination and quantitative polymerase chain reaction (PCR) found that TCN1 and CCL27 were involved in the process of cholesteatoma keratinocytes and dermal endothelial cells. In skin tumors derived from keratinocytes, there is a protective mechanism of antitumor T cell-mediated by reducing CCL27 expression. AIM: The objective of this study was to investigate the expression of chemokine ligand 27 (CCL27) in cholesteatoma. METHODS: This is a cross-sectional comparative study. Cholesteatoma specimens were obtained from 15 patients who underwent surgery and 15 normal retroauricular skin as control. The specimen’s gene expression was examined with real-time PCR (RT-PCR). RESULTS: The expression of CCL27 was 36.215 ± 45.848 ng/ul in cholesteatoma, while it is 9.692 ± 15.760 ng/ul in normal retroauricular skin. The expression of CCL 27 in cholesteatoma was higher than in normal retroauricular skin, but it was not significant (p > 0.05) CONCLUSION: The expression of CCL27 in cholesteatoma was higher than in normal retroauricular skin.

show abstract

Section: Introductionmentioning

confidence: 99%

“…The prevalence of CSOM in the world is 65-330 million people, especially in developing countries. The prevalence of CSOM in Indonesia, according to the national survey of sight and hearing health in 1994-1996, ranges from 3 to 5.2% [1], [4].…”

Section: Introductionmentioning

confidence: 99%