Adolescent emotional problems are prevented through biological, psychological, and social factors (biopsychosocial). The biopsychosocial model is used to understand children's mental health conditions in the community. This study aims to identify the effect of biological, psychological, and social factors on adolescents' emotional problems in Medan City. Data were analyzed using a quantitative approach with Structural Equation Modeling (SEM) and Partial Least Squares (PLS) version 3.0. A simple probability sampling technique was carried out, and randomization was obtained from a random number table generated by computer. The sample size was 150 adolescents, calculated using the rule of thumb in the SEM model application. The results showed that the biological, psychological, and social factors are significantly related to adolescent emotional problems because it has a p-value <0.05. However, social variables affect mental health conditions at 6.567, and family support becomes the most dominant indicator since it has 37.342. Adolescent emotional problems are influenced by biological, psychological, and social factors. Meanwhile, a social variable such as family support greatly affects children's mental health.