Hubungan Kepatuhan Minum Obat Dengan Tekanan Darah Pada Penderita Hipertensi

Abstract

AbstrakLatar belakang: Sampai saat ini, hipertensi masih merupakan tantangan besar di Indonesia. Kepatuhan pasien dalam menggunakan obat berpengaruh terhadap keberhasilan terapi pengobatan. Adanya ketidakpatuhan pasien hipertensi dalam minum obat dapat memberikan efek negative yang sangat besar, seperti munculnya komplikasi. Tujuan: Mengetahui hubungan kepatuhan minum obat dengan tekanan darah pada penderita hipertensi di Puskesmas Karangjambu Kabupaten Purbalingga. Metode: Desain penelitian ini adalah cross sectional study. Responden dalam penelitian ini adalah pasien hipertensi di Puskesmas Karangjambu Kbupaten Purbalingga. Sampel diambil menggunakan teknik accidental sampling dengan jumlah 86 responden. Data dikumpulkan pada bulan Mei 2021 menggunakan kuesioner 8 – Item Morisky Medication Aderence Scale (MMAS – 8) dan pengukuran tekanan darah secara langsung. Hasil: Penelitian ini menunjukkan bahwa Sebagian besar responden adlaah perempuan (86%), sebgain besar berada pada kategori tingkat kepatuhan sedang (47%) dan pada kategori hipertensi tahap 2 (63%). Uji stastistik didapatkan nilai p value 0.901 menunjukkan bahwa tidak ada hubungan kepatuhan minum obat dengan tekanan darah pada penderita hipertensi. Kesimpulan: Tidak ada hubungan kepatuhan minum obat dengan tekanan darah pada penderita hipertensi AbstractBackground: In Indonesia, hypertension is still a major problem. Adherence to treatment is critical for hypertension patients' long-term health and well-being. Adherence are required for hypertension therapy to be effective, and altering these patients' behavior has the greatest potential for improving hypertensive control. Objectives: To explore the relationship between medication adherence and blood pressure in hypertension patients. Methods: We used the cross-sectional study. This research sample was hypertension patients at Karangjambu Health Centre Purbalingga Regency. We included 89 respondents by accidental sampling technique. We collected the data by questionnaire. The Gamma & Sommers’d test was performed to analyze the data. Results: This research showed that that the majority of respondents were women (86%), the moderate category had the highest level of adherence (47%) and the most respondents suffer from hypertension stage 2 (63%). The statistical test result of 0.910 suggested that there was no relationship between medication adherence and blood pressure in hypertensive patients. Conclusions: There was also no significant between medication adherence and blood pressure.

8- Hydroxy -deoxyguanosine (8-OHdG) urine as a biomarker of oxidative damage in early elderly hypertension

“…ROS can trigger aging at the cellular level, due to the cessation of replication due to damage to the cell structure, resulting in oxidative stress. Oxidative stress occurs due to the production of free radicals that exceed antioxidant levels, resulting in an imbalance (12) (13) (14) . ROS can trigger inflammation in the renal glomeruli which could affect the blood pressure regulation and trigger endothelial dysfunction (15) (16) (3) .…”

“…Increased blood pressure caused by oxidative stress, could increase the activity of NADPH (Nicotinamide Adenine Dinucleotide Phosphate) oxidate. NADPH oxidate increases the production of ROS which could react with NO causing the decrease in NO bioavailability resulting in the impairement of vasodilation (14) . The increasing age will affect the stiffness of the blood vessel walls and could cause the blood vessels to become stiff and the decrease in arterial compliance, thereby increasing blood pressure (17) (6) .…”

“…The increasing age will affect the stiffness of the blood vessel walls and could cause the blood vessels to become stiff and the decrease in arterial compliance, thereby increasing blood pressure (17) (6) . The incidence of hypertension is expected to continue to increase considering the higher life expectancy (14) .…”

Pemeriksaan Tekanan Darah Melalui Program Pelayanan Kesehatan Gratis Di Amahami Kota Bima

“…High blood pressure is defined as a systolic pressure between 120 and 129 with a diastolic pressure less than 80 (Sammeng and Lestaluhu 2021). Whereas low blood pressure, or hypotension, is a systolic blood pressure lower than 90 or a diastolic blood pressure lower than 60 (Nugrawati 2022). Symptoms of low blood pressure include dizziness, weakness or even fainting.…”

Hubungan Usia terhadap Derajat Keparahan Hipertensi di Puskesmas Imbanagara Ciamis Tahun 2023

“…Penelitian ini sejalan dengan penelitian yang dilakukan oleh Merdy, dkk., tentang hubungan umur dan stres dengan kejadian hipertensi pada lansia di Puskesmas Tona Kecamatan Tahuna Timur Kabupaten Sangihe, yang menyatakan bahwa paling banyak responden pada penelitiannya mengalami hipertensi grade II pada lansia dan usia pertengahan (50-59 tahun) (13). Selain itu, penelitian yang dilakukan oleh Swadito Wicaksono (14) menyatakan bahwa proporsi hipertensi tertinggi terjadi pada kelompok umur 45-59 tahun dengan persentasi sebesar 72,22%. Hasil tersebut sejalan dengan teori bahwa pertambahan usia sebanding lurus dengan kejadian hipertensi karena semakin bertambah usia maka elastisitas pembuluh darah akan semakin menurun.…”