Hubungan Stadium Hipertensi dengan Derajat Perlemakan Menggunakan Indeks Hepatorenal Sonografi

Abstract

AbstrakHipertensi merupakan prekursor perkembangan perlemakan hati nonalkoholik. Modalitas pencitraan USG paling banyak digunakan untuk menegakkan diagnosis perlemakan hati nonalkoholik. Saat ini dikembangkan teknik USG menggunakan parameter indeks hepatorenal sonografi yang dihitung dengan program software ImageJ dan digunakan untuk memprediksi derajat perlemakan hati. Penelitian ini bertujuan mengetahui hubungan antara stadium hipertensi dan derajat perlemakan hati nonalkoholik menggunakan indeks hepatorenal sonografi. Penelitian menggunakan studi observasional analitik dengan rancangan cross sectional, pengambilan sampel dilakukan secara consecutive admission. Penelitian dilaksanakan di Bagian Radiologi RSUP Dr. Hasan Sadikin Bandung periode Juni-Agustus 2016. Subjek penelitian 50 orang, laki-laki 22 orang, perempuan 28 orang, usia termuda 25 tahun, dan tertua 77 tahun. Hasil penelitian melalui uji statistik chi-square menunjukkan derajat perlemakan hati nonalkoholik ringan lebih banyak pada prehipertensi (9 dari 16), derajat sedang pada hipertensi stadium I (10 dari 19), dan derajat berat pada hipertensi stadium II (8 dari 15) dengan p<0,001. Perlemakan hati nonalkoholik derajat sedang dan berat lebih sering ditemukan pada perempuan dengan hipertensi (p=0,005) Simpulan, terdapat hubungan antara stadium hipertensi dan derajat perlemakan hati nonalkoholik menggunakan indeks hepatorenal sonografi. Kata kunci: ImageJ, indeks hepatorenal sonografi, perlemakan hati nonalkoholik, stadium hipertensi, USG The Association of Hypertension Stage and Non-Alcoholic Fatty Liver Degree Using Hepatorenal Sonography Index AbstractHypertension is considered as a precursor to the development of non-alcoholic fatty liver disease (NAFLD). Ultrasonography techniques have been developed using sonography hepatorenal index parameter calculated by ImageJ, that can predict the degree of NAFLD. This study aim to determine the relationship between hypertension stage and the degree of NAFLD using sonography hepatorenal index. The research is an observational using cross sectional methods, with consecutive admission sampling method. The study was performed at Dr. Hasan Sadikin Hospital Bandung from June to August 2016. A total of 50 subjects, 22 men and 28 women, with the youngest 25 and the oldest 77 years old participated. Results indicated that the mild degree of NAFLD were higher on prehypertension (9 of 16), the moderate degree on stage I hypertension (10 of 19), while the severe degree found on stage II hypertension (8 of 15), with p<0.001. Moderate and severe degree of NAFLD in hypertensive patient was more common in women (p=0.005). In conclusion, there is a relationship between hypertension stage and the degree of NAFLD.

Correlation between Steatosis Degree and Hypertension Degree in Non-Alcoholic Fatty Liver Disease Patients in Indonesia

“…While Ryoo et al showed the distribution of NAFLD patients in Korea was very high in normal-mild degrees at 95.44%, moderate degrees at 4.45%, and severe degrees at 0.11%. Although our results differed from those other studies, all studies had more populations with mild to moderate degrees of steatosis and less prevalent severe degrees of steatosis [21].…”

“…This study also observed that 56.1% of the subjects were female. Other study in Indonesia such as Marina et al noted that 56% of their subjects were female and identified a significant association between female and severity of NAFLD and also Rengkung, et al reported a higher proportion of females, accounting for 67% of their study population [20,21].These findings support the theory proposed by other studies, which more commonly occurs in women, specifically those experiencing menopause, owing to the deficiency of anti-inflammatory oestrogen [5,20,22].…”

“…The highest proportion of NAFLD based on age group were elderly 61-70 years old (28.4%), while Duseja et al suggested that NAFLD typically occurs during the fourth and fifth decades of life, with a peak incidence at 40-49 years in males and 50 years in females. However, separate studies in Indonesia indicated that NAFLD is more prevalent in the age range of 51-60 years [20,21]. This study also observed that 56.1% of the subjects were female.…”