During the entire electronic system data transmission process, sensors can be used to capture information, and more importantly, isolators can be used to ensure the integrity of data transmission. For a long time, optocoupler isolators have been used to achieve electrical isolation. With the progress of sensing technology and the rapid development of the semiconductor industry, using giant magnetoresistance isolation technology to achieve electrical isolation is more conducive to chip integration. This article first introduces the giant magnetoresistance effect, the explanation of its theoretical model, and the areas that still need to be studied. Then, the principle and working process of the giant magnetoresistance isolator are discussed with its structure as the core. Finally, the development direction of giant magnetoresistance isolation devices is prospected.