Huge mediastinal mass with minimal symptoms: thymolipoma

Ganesh, Yadala; Yadala, Vivek; Nalini, Y.; Dal, Avinash; Raju, Anil Dronam

doi:10.1136/bcr.05.2010.2984

Case Reports

2011

DOI: 10.1136/bcr.05.2010.2984

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Huge mediastinal mass with minimal symptoms: thymolipoma

Yadala Ganesh

Vivek Yadala

Y. Nalini

et al.

Abstract: A 35-year-old Indian working in Dubai had come to India for his annual vacation. He presented with a shortness of breath and mild chest discomfort of 3 months duration. Routine investigations gave normal results, except for his chest x-ray that showed homogenous opacity in the right mid and lower zones. Chest CT scan revealed a huge mass with fat and soft tissue involving the anterior mediastinum predominantly on the right side extending into the pericardiac region. The mass was pushing the right hemidiaphragm… Show more

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Cited by 3 publications

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Paediatric giant cervicomediastinal thymolipoma

Patel

Evans

et al. 2014

BMJ Case Reports

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We report a case of a 11-year-old boy who presented with a massive soft tissue right cervical painless and progressive lesion displacing trachea to the left and extending into the anteriosuperior mediastinum which was diagnosed to be a lipomatous mass on chest CT scan. Subsequent biopsy and total excision proved it to be a giant cervicomediastinal thymolipoma. It was successfully excised with excellent prognosis and long-term results. A giant paediatric cervicomediastinal thymolipoma is a rare, benign, mediastinal mass of thymic origin. It may remain asymptomatic despite massive size and up to 50% in some series are associated with autoimmune disease. CT scan gives fat density and encapsulated benign nature and biopsy usually establishes the diagnosis. Preoperative tissue diagnosis is important as now the availability of thoracoscopic option is best suited to reduce morbidity. Treatment of choice is total excision using open surgical, minimal invasive techniques or robotic surgery and the prognosis is excellent.

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Paediatric giant cervicomediastinal thymolipoma

Patel

Evans

et al. 2014

BMJ Case Reports

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Thymolipoma – the frontier between hamartoma and neoplasia?

Amălinei

Grigoraș²,

Bălan³

et al. 2021

Rom J Morphol Embryol

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Thymolipoma is an uncommon benign thymus lesion, with a partially deciphered etiopathogeny, being most frequently diagnosed in young patients, regardless of gender. Incidentally diagnosed in asymptomatic patients, larger thymolipomas lead to symptoms related to neighboring mediastinal structures compression, with an intensity which is correlated with the mass size. Our review presents the main epidemiological, pathogenic, clinicopathological and morphological characteristics of this rare pathology. Sometimes, thymolipomas may be associated with paraneoplastic syndromes, which are alleviated by the mass complete surgical resection. Imagistics may orientate the diagnosis, which is certified by the microscopic examination of the resection specimens. Extensive thymectomy remains the current therapeutic option and new tools have been developed to increase the accuracy of the surgical procedure to avoid incidental lesions of the important elements of the anterior mediastinum. Although rare, thymolipomas should be considered in the differential diagnosis of mediastinal masses and of paraneoplastic syndromes.

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Surgical treatment of giant mediastinal tumors

Qin

2021

Turk Gogus Kalp Dama

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Background This study aims to evaluate the surgical treatment outcomes of giant mediastinal tumors. Methods Between July 2013 and July 2018, medical data of a total of 31 patients (26 males, 5 females; mean age 27.7±8.2 years; range, 18 to 56 years) who underwent radical surgery for a giant mediastinal tumor in our center and 47 cases (26 males, 21 females; mean age 45.4±16.7 years; range, 19 to 62 years) of giant mediastinal tumors retrieved from the National Center for Biotechnology Information database were retrospectively reviewed. Two-year overall survival and disease-free survival rates of the patients were evaluated. Results All patients underwent radical surgery (R0 resection). Symptoms caused by giant mediastinal tumors were relieved after radical surgery during follow-up. The two-year overall survival and disease-free survival rates were 100% and 86.7%, respectively, indicating a good prognosis. The surgical procedures for malignancies were more difficult than those for benign pathologies. Conclusion Radical surgery is the mainstay for treatment of giant mediastinal tumors to relieve symptoms in a short period of time and to achieve a good prognosis for up to two years, regardless of adjuvant therapy. The surgical route should be cautiously planned before radical surgery to reduce complications.

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Huge mediastinal mass with minimal symptoms: thymolipoma

Cited by 3 publications

References 10 publications

Paediatric giant cervicomediastinal thymolipoma

Paediatric giant cervicomediastinal thymolipoma

Thymolipoma – the frontier between hamartoma and neoplasia?

Surgical treatment of giant mediastinal tumors

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