Huge pelvic parachordoma: fine needle aspiration cytology and histological differential diagnosis

Samaka, Rehab Monir; Kandil, Mohamed

doi:10.4081/rt.2012.e53

Cited by 7 publications

(8 citation statements)

References 17 publications

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“…Myoepithelial carcinoma (MEC) is a rare soft tissue tumor characterized by slow growth, occasional late recurrence, and rarely metastasizing . Diagnostic problems may arise due to histopathology and immunophenotype heterogeneity of MEC . Histologically, the tumors are composed of myoepithelial cells arranged in sheets or nests showing epithelioid, plasmacytoid, clear or spindle cell morphology intermixed with myxoid, chondroid, or fibrous stroma .…”

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confidence: 99%

Soft tissue myoepithelial carcinoma with rhabdoid‐like features andEWSR1rearrangement: Fine needle aspiration cytology with histologic correlation

Machado

López-Soto²,

Rubio

et al. 2015

Diagnostic Cytopathology

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A new case of soft tissue myoepithelial carcinoma (MEC) with rhabdoid-like differentiation is presented including cytologic, histopathologic, immunohistochemical, and molecular biologic features. A 45-year-old woman was admitted to the Hospital with nodular mass involving the lower part of the abdominal wall. Fine-needle aspiration cytology showed a round cell tumor with abundant cytoplasm in the myxoid background. The nuclei were uniform, round to ovoid, with finely distributed chromatin, nucleoli, and pale, vacuolated, or eosinophilic cytoplasm with rhabdoid-like appearance resembling a soft tissue malignant rhabdoid tumor. The surgically removed tumor was poorly demarcated, yellow, soft, and myxoid. The histopathology revealed sheets of poorly differentiated round malignant cells with focal myxoid stroma and rhabdoid-like morphology. Immunohistochemistry showed positivity for CK (AE1/AE3), EMA, S100, vimentin, CD99, and SMA; however desmin, CD34, and gliofibrilar acid protein (GFAP) were negative. Tumor cells revealed loss of INI1 expression. The EWSR1 gene rearrangement was detected by fluorescence in situ hybridization (FISH), but molecular biology failed to detect EWSR1/ETS, EWSR1/ NR4A3, EWSR1/DDIT3, EWSR1/ATF1, EWSR1-POU5F1, EWSR1/ZNF444, EWSR1-PBX1 gene fusions. The final diagnosis was soft tissue malignant myoepithelioma with rhabdoid changes and EWSR1 gene rearrangement. The differential diagnosis included soft tissue malignant rhabdoid tumor, cellular extraskeletal myxoid chondrosarcoma, proximal epithelioid sarcoma, and other soft tissue tumor with EWSR1 rearrangement. To our knowledge, this is the first case of MEC with rhabdoid features and description of fine-needle aspiration cytology. Diagn. Cytopathol. 2015;43:421-426. V C 2015 Wiley Periodicals, Inc.

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confidence: 99%

Soft tissue myoepithelial carcinoma with rhabdoid‐like features andEWSR1rearrangement: Fine needle aspiration cytology with histologic correlation

Machado

López-Soto²,

Rubio

et al. 2015

Diagnostic Cytopathology

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“…The most common presentation for this rare tumor is nonspecific with most patients presenting with a painless swelling or slow growing mass. Painful masses have also been described, particularly large lesions [8] , [9] .…”

Section: Discussionmentioning

confidence: 99%

Recurrent parachordoma of the lower back: A case report

Belzarena

Makanji

Joyce

2019

Radiology Case Reports

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Parachordoma is a rare entity with less than 50 cases described in the literature. This soft-tissue tumor resembles chordomas as well as extraskeletal myxoid chondrosarcomas and has only recently been fully characterized. Here we describe the case of a patient with a lower back parachordoma and its subsequent postresection recurrence 9 years after the initial procedure, emphasizing the importance of long-term follow-up in individuals with this diagnosis.

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“…Parachordomas have been reported to occur in the pelvis and gastric serosa also. [ 16 17 ] Fewer than 60 cases of parachordoma have been reported till date,[ 2 16 ] and include intraneural parachordoma[ 4 ] and parachordomas of the skull bone. [ 19 ] However, there have been no reported cases of an intracranial parachordoma till the present reported case.…”

Section: Discussionmentioning

confidence: 99%

“…A small number of these tumors develop local recurrences and are rarely seen to metastasize. [ 16 ] We report the first case of an intracranial parachordoma in a 52-year-old male.…”

Section: Introductionmentioning

confidence: 99%

Primary intracranial Parachordoma: An unusual tumor in brain

Ghanta¹,

Uppin

Koti

et al. 2014

Surg Neurol Int

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Background:Parachordomas are rare soft tissue tumors commonly occurring in limbs, chest, Abdomen, and back. The World Health Organization (WHO) classification includes parachordomas in the same group as mixed tumors and myoepitheliomas. Exact histogenesis of this tumor is unclear.Case Description:A 52-year-old male presented with headache and blurring of vision since one month. Preoperative computed tomography (CT) scan of brain revealed left parieto-occipital tumor extending up to the trigone. Total excision of the tumor was done. Histopathologically, the tumor was composed of relatively uniform cells with eosinophilic cytoplasm in a myxoid stroma and with cartilaginous and osseous metaplasia. The tumoral cells were immunoreactive for cytokeratin, epithelial membrane antigen (EMA), S-100, and vimentin. The constellation of findings revealed the tumor to be parachordoma. Magnetic resonance imaging (MRI) brain during follow-up at one year showed no recurrent tumor. No adjuvant therapy was given to this patient.Conclusion:This is the first reported case of primary intracranial parachordoma. It is difficult to diagnose the lesion preoperatively by imaging alone. Long-term follow-up is necessary in view of few reports in literature of recurrence and metastasis, of parachordomas in other anatomical locations.

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Huge pelvic parachordoma: fine needle aspiration cytology and histological differential diagnosis

Cited by 7 publications

References 17 publications

Soft tissue myoepithelial carcinoma with rhabdoid‐like features andEWSR1rearrangement: Fine needle aspiration cytology with histologic correlation

Soft tissue myoepithelial carcinoma with rhabdoid‐like features andEWSR1rearrangement: Fine needle aspiration cytology with histologic correlation

Recurrent parachordoma of the lower back: A case report

Primary intracranial Parachordoma: An unusual tumor in brain

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