Hughes-Stovin Syndrome: A Dilemma for Anticoagulation

Vaidya, Gaurang; Syed, Wajihuddin; Kothari, Shalin; Chaudhary, Omair

doi:10.1378/chest.1994999

Cited by 1 publication

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“…Surgical resection may be performed in localized aneurysms to one segment or lobe to control massive hemoptysis. This recommendation has been made in several case reports in the literature [1,[4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical paradigms of HSS can be divided into three stages [ 5 ], the first being the presence of thrombophlebitis, followed by progression to pulmonary and/or bronchial involvement, and finally, hemoptysis, which may be lethal when caused by aneurysm rupture. These stages mostly follow in order, with the first two stages considered the criteria for the diagnosis of HSS and the last stage associated with untreated patients.…”

Section: Discussionmentioning

confidence: 99%

“…Medical treatment consists of corticosteroids and cytotoxic agents, among which cyclophosphamide is considered the primary choice [ 1 ]. Due to the possible risk of lethal hemorrhage, anticoagulation is contraindicated in HSS, even in the presence of pulmonary thromboembolism (PTE) [ 5 , 6 ]. However, anticoagulation may be considered in cases of massive PTE or intracardiac thrombosis [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Hughes-Stovin Syndrome: A Rare Cause of Thrombosis and Pulmonary Artery Aneurysm

Yalçın¹,

Ensarioglu²,

Kurt³

2023

Cureus

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Hughes-Stovin Syndrome (HSS) is a rare clinical condition characterized by thrombophlebitis as well as multiple pulmonary and bronchial aneurysms. It commonly presents with coughing, dyspnea, fever, chest pain, and hemoptysis, and its management usually consists of surgical and medical approaches. In this report, we discuss a case of a patient with HSS. A 30-year-old male patient was admitted to the pulmonary medicine ward for hemoptysis. After evaluation with chest CT, bilateral pulmonary embolism and pulmonary aneurysms were observed. Due to a history of aphthous lesions, Behçet's disease (BD) was considered the initial diagnosis; however, the patient did not fit the criteria and was later diagnosed with HSS. Intravenous methylprednisolone was initiated, along with a maintenance treatment with cyclophosphamide. Treatment response was observed in the fourth month; however, due to the persistence of hemoptysis, additional cycles of cyclophosphamide were later required, under which the patient's condition has been stable. HSS currently lacks clear diagnostic criteria, and further studies are needed to investigate genetic backgrounds, familial transmissions, and treatment alternatives.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%