Huisgen 3 + n Dipolar Cycloaddition Reactions: An Accessible and Useful Tool in Modern Organic and Heterocycle Synthesis

Mangalagiu, Ionel I.

doi:10.3390/molecules28155692

Cited by 1 publication

(1 citation statement)

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“…The Huisgen Cycloaddition is a chemical reaction that results in the formation of a 5-membered ring, specifically a triazole skeleton, through the interaction between 1,3-dipole and a dipolarphile. [1,2] To achieve this reaction, the Azide-Alkyne Huisgen Cycloaddition involves two essential reactants: an organic azide and a terminal or internal alkyne, which combine to produce 1,2,3-triazole. [3][4][5] The pioneering work of Rolf Huisgen first elucidated the extent and potential of this reaction.…”

Section: Introductionmentioning

confidence: 99%

A New Insight Into The Huisgen Reaction: Heterogeneous Copper Catalyzed Azide‐Alkyne Cycloaddition for the Synthesis of 1,4‐Disubstituted Triazole (From 2018–2023)

Kasana,

Nigam,

Singh

et al. 2024

Chemistry & Biodiversity

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The Huisgen cycloaddition, often referred to as 1,3‐Dipolar cycloaddition, is a well‐established method for synthesizing 1,4‐disubstituted triazoles. Originally conducted under thermal conditions [3+2] cycloaddition reactions were limited by temperature, prolonged reaction time, and regioselectivity. The copper catalyzed azide‐alkyne cycloaddition (CuAAC) has emerged as a prominent method for producing 1,2,3‐triazole with excellent yields and exceptional regioselectivity. Copper catalysts conventionally facilitate azide‐alkyne cycloadditions, but challenges include instability and recycling issues. In recent years, there has been a growing demand for heterogeneous catalysts in various chemical reactions. The present review covers recent advancements from year 2018 to 2023 in the field of click reactions for obtaining 1,2,3‐triazoles through Cu catalyzed 1,3‐dipolar azide‐alkyne cycloaddition and the properties of the catalyst, reaction conditions such as solvent, temperature, reaction time, and the impact of different heterogeneous copper catalysts on product yield.

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Section: Introductionmentioning

confidence: 99%

A New Insight Into The Huisgen Reaction: Heterogeneous Copper Catalyzed Azide‐Alkyne Cycloaddition for the Synthesis of 1,4‐Disubstituted Triazole (From 2018–2023)

Kasana,

Nigam,

Singh

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

Huisgen 3 + n Dipolar Cycloaddition Reactions: An Accessible and Useful Tool in Modern Organic and Heterocycle Synthesis

Abstract: Heterocycle derivatives have been reported as invaluable compounds in agriculture […]

Cited by 1 publication

References 9 publications

A New Insight Into The Huisgen Reaction: Heterogeneous Copper Catalyzed Azide‐Alkyne Cycloaddition for the Synthesis of 1,4‐Disubstituted Triazole (From 2018–2023)

A New Insight Into The Huisgen Reaction: Heterogeneous Copper Catalyzed Azide‐Alkyne Cycloaddition for the Synthesis of 1,4‐Disubstituted Triazole (From 2018–2023)

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