Human Acyl-CoA: Cholesterol Acyltransferase Inhibitory Activities of Aliphatic Acid Amides from Zanthoxylum piperitum DC.

Park, Yong‐Dae; Lee, Woo Song; An, Soon Il; Jeong, Tae Sook

doi:10.1248/bpb.30.205

Cited by 15 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bifidobacterium animalis also increases polyamine concentrations and has been shown to alter IGF-1 expression (Matsumoto et al, 2011). Similarly, Bacillus polyfermenticus , also known to possess chemopreventive efficacy, has been shown to modulate inflammatory and proliferative signals, such as those associated with EGFR pathway (Kim et al, 2006; Lee et al, 2007; Park et al, 2007). The ErbB receptor family, including EGFR, is important in cancer development and these family members are over expressed in various cancers including CRC (Holbro et al, 2003; Kamath and Buolamwini, 2006).…”

Section: Biological Targets Of Nutraceuticals For Crc Preventionmentioning

confidence: 99%

Identifying Molecular Targets of Lifestyle Modifications in Colon Cancer Prevention

Derry¹,

Raina²,

Agarwal³

et al. 2013

Front. Oncol.

View full text Add to dashboard Cite

One in four deaths in the United States is cancer-related, and colorectal cancer (CRC) is the second leading cause of cancer-associated deaths. Screening strategies are utilized but have not reduced disease incidence or mortality. In this regard, there is an interest in cancer preventive strategies focusing on lifestyle intervention, where specific etiologic factors involved in cancer initiation, promotion, and progression could be targeted. For example, exposure to dietary carcinogens, such as nitrosamines and polycyclic aromatic hydrocarbons influences colon carcinogenesis. Furthermore, dietary deficiencies could alter sensitivity to genetic damage and influence carcinogen metabolism contributing to CRC. High alcohol consumption increases the risk of mutations including the fact that acetaldehyde, an ethanol metabolite, is classified as a group 1 carcinogen. Tobacco smoke exposure is also a risk factor for cancer development; approximately 20% of CRCs are associated with smoking. Additionally, obese patients have a higher risk of cancer development, which is further supported by the fact that physical activity decreases CRC risk by 55%. Similarly, chronic inflammatory conditions also increase the risk of CRC development. Moreover, the circadian clock alters digestion and regulates other biochemical, physiological, and behavioral processes that could influence CRC. Taken together, colon carcinogenesis involves a number of etiological factors, and therefore, to create effective preventive strategies, molecular targets need to be identified and beleaguered prior to disease progression. With this in mind, the following is a comprehensive review identifying downstream target proteins of the above lifestyle risk factors, which are modulated during colon carcinogenesis and could be targeted for CRC prevention by novel agents including phytochemicals.

show abstract

Section: Biological Targets Of Nutraceuticals For Crc Preventionmentioning

confidence: 99%

Identifying Molecular Targets of Lifestyle Modifications in Colon Cancer Prevention

Derry¹,

Raina²,

Agarwal³

et al. 2013

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…It is also used to help the cardiovascular system [ 12 ]. Some ZP compounds have been described to inhibit cholesterol acetyltransferase, thus contributing to helping the cardiovascular system, which validates the traditional use since cholesterol ester plays an important role in cardiovascular diseases [ 13 ]. The fact that ZP is used for digestive disorders could indicate an effect on stomach pain that might suggest pain relief properties for this species.…”

Section: Introductionmentioning

confidence: 96%

Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil

Donald

Fernandes

Boylan

2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Zanthoxylum piperitum DC. (ZP) is a traditional medicinal plant used mainly in countries from Asia such as Japan. This study aimed to investigate the antinociceptive effect of ZP essential oil (ZPEO). The major component present in the essential oil was beta-phellandrene (29.39%). Its antinociceptive activity was tested through animal models (formalin-, capsaicin-, and glutamate-induced paw licking and hot plate). The anti-inflammatory effect was evaluated through the carrageenan-induced leukocyte migration into the subcutaneous air pouch (SAP), with measurement of cytokines. The results showed antinociceptive effect for ZPEO for the first phase of the formalin-induced licking, glutamate, and hot plate tests. However, ZPEO had no effect on reducing paw licking induced by capsaicin. Finally, ZPEO had no effect against inflammation induced by carrageenan.

show abstract

“…Some of the aliphatic acid amides display antioxidant activities, modulatory effects on relaxing the circle muscle of the gastric body (β- and γ-sanshool), anthelmintic, cytotoxic properties [10,11,12], as well as anti-type-1 diabetes (i.e., γ-sanshool) [13] and anti-tumor effects [14]. In addition, three aliphatic acid amides (β-, γ- and hydroxy-β-sanshool) exhibited human acyl-CoA: cholesterol acyltransferase inhibitory activities [15], and tumuramide C, ZP-amide A, and ZP-amide D exerted significant effects on PPAR transactivational activity [16]. Most recently, Hofmann et al [1] have shown that the all- trans -configured amides hydroxy-β-sanshool and hydroxy-γ-isosanshool from Z. piperitum induced a numbing and anesthetic sensation.…”

Section: Introductionmentioning

confidence: 99%

Isobutylhydroxyamides from Zanthoxylum bungeanum and Their Suppression of NO Production

Wang

Luo

et al. 2016

Molecules

View full text Add to dashboard Cite

Abstract:Four new unsaturated aliphatic acid amides, named zanthoamides A-D (1-4), and eight known ones-tetrahydrobungeanool (5), ZP-amide A (6), ZP-amide B (7), ZP-amide C (8), ZP-amide D (9), ZP-amide E (10), bugeanumamide A (11), and (2E,7E,9E)-N-(2-hydroxy-2-methylpropyl)-6,11-dioxo-2,7,9-dodecatrienamide (12)-were isolated from the pericarps of Zanthoxylum bungeanum. The structures of these compounds were elucidated by extensive use of spectroscopic methods, including HRESIMS, 1D and 2D NMR analyses and comparison with previously reported data. Compound 4 contained a rare C 6 fatty acid unit with an acetal group. Results revealed that compounds 1, 5, 6, and 12 showed inhibitory effects on nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophages, with IC 50 values of 48.7 ± 0.32, 27.1 ± 1.15, 49.8 ± 0.38, and 39.4 ± 0.63 µM, respectively, while the other compounds were inactive (IC 50 > 60 µM). They could contribute to the anti-inflammatory effects of Z. bungeanum by suppression of NO production.

show abstract

Human Acyl-CoA: Cholesterol Acyltransferase Inhibitory Activities of Aliphatic Acid Amides from Zanthoxylum piperitum DC.

Cited by 15 publications

References 19 publications

Identifying Molecular Targets of Lifestyle Modifications in Colon Cancer Prevention

Identifying Molecular Targets of Lifestyle Modifications in Colon Cancer Prevention

Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil

Isobutylhydroxyamides from Zanthoxylum bungeanum and Their Suppression of NO Production

Contact Info

Product

Resources

About