Human adenovirus-36 antibody status is associated with obesity in children

The role of adenovirus 36 as a risk factor in obesity: The first clinical study made in the fatty tissues of adults in Turkey

“…In the adipose tissue samples obtained, no Ad-36 DNA was detected. While our serological results show similarities with the serologic-based studies performed in the USA and Europe [8,16,17,35], our result of no detectable Ad-36 DNA in human adipose tissue samples differed from the results of Pasarica et al [20] and Salehian et al [21]. However, our results showed similarity with the study of Goossens et al [38].…”

“…The relationship between Ad-36 and obesity was also reported in similar studies [17,19,35]. Despite these studies, there are also contradictory studies.…”

Adenovirus-36 Seropositivity Enhances Effects of Nutritional Intervention on Obesity, Bright Liver, and Insulin Resistance

“…The worldwide nearly simultaneous manifestations of obesity can be explained by changes in food intake and exercise, but a contribution of infectious factors is plausible [35]. The association of Ad36 seropositivity with obesity is confirmed in adults [36] and in children [37][38][39]. Moreover, Ad36 seropositive status (Ad36?)…”

Adenovirus 36 infection and obesity

“…39 Atkinson et al found that 25 of 84 children (30%) had antibodies against AD-36 and significantly higher BMI z-scores (1.92 vs. 1.65, p < 0.01) and larger waist circumferences (96.3 cm vs. 90.7 cm, p = 0.05) than those found in the uninfected children. 40 Finally, Na et al found that more obese than non-obese subjects among 318 Korean children were positive for AD-36 antibodies (28.5% vs. 13.5%). 41 Within the obese group, the children who were positive for AD-36 had higher TC and TG levels, but these associations were not present in the non-obese group.…”

“…Among the subset of obese subjects, those that were AD-36 positive had significantly larger anthropometric measures, including weight, BMI, waist circumference, and waist/height ratio Atkinson et al 40 Twenty-five of eighty-four children (30%) had antibodies against AD-36. In comparison with the uninfected subjects, they had significantly higher BMI z-scores (1.92 vs. 1.65; p < 0.01) and larger waist circumferences (96.3 vs. 90.7 cm; p = 0.05) Na et al 41 Among 318 Korean children, more obese than non-obese subjects were positive for AD-36 antibodies (28.5% vs. 13.5%).…”