Human Adipose Tissue-Derived Stromal/Stem Cells Promote Migration and Early Metastasis of Head and Neck Cancer Xenografts

Rowan, Brian G.; Lacayo, Eduardo A.; Sheng, Mei; Anbalagan, Muralidharan; Gimble, Jeffrey M.; Jones, Ryan K.; Joseph, Walter J.; Friedlander, Paul L.; Chiu, Ernest S.

doi:10.1093/asj/sjv090

Cited by 32 publications

(37 citation statements)

References 26 publications

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“…AT-MSCs promote migration and early metastasis of head/neck cancer cell lines Cal-27 and SCC-4 in vitro and in xenografts 42. AT-MSCs inhibit the growth of human melanoma cell lines (A375SM and A375P) by inducing apoptosis and altering cell-cycle distribution in vitro .…”

Section: Mscs In Anticancer Therapiesmentioning

confidence: 98%

Human-derived normal mesenchymal stem/stromal cells in anticancer therapies

Zhang¹,

Yang²,

Qin³

et al. 2017

J. Cancer

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The tumor microenvironment (TME) not only plays a pivotal role during cancer progression and metastasis, but also has profound effects on therapeutic efficacy. Stromal cells of the TME are increasingly becoming a key consideration in the development of active anticancer therapeutics. However, dispute concerning the role of stromal cells to fight cancer continues because the use of mesenchymal stem/stromal cells (MSCs) as an anticancer agent is dependent on the specific MSCs subtype, in vitro or in vivo conditions, factors secreted by MSCs, types of cancer cell lines and interactions between MSCs, cancer cells and host immune cells. In this review, we mainly focus on the role of human-derived normal MSCs in anticancer therapies. We first discuss the use of different MSCs in the therapies for various cancers. We then focus on their anticancer mechanism and clinical application.

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Section: Mscs In Anticancer Therapiesmentioning

confidence: 98%

Human-derived normal mesenchymal stem/stromal cells in anticancer therapies

Zhang¹,

Yang²,

Qin³

et al. 2017

J. Cancer

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“…Stem cell reconstruction has been most extensively studied in breast cancer and remains intensely controversial . An influential mouse study with ductal breast carcinoma cells found increased metastases when MSC were administered; similar results occurred with head and neck cancer cell lines . Nonetheless, numerous conflicting animal and human studies have led to uncertainty about long‐term outcomes .…”

Section: Discussionmentioning

confidence: 99%

Repairing the vibratory vocal fold

Long

2017

The Laryngoscope

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Objective: A vibratory vocal fold replacement would introduce a new treatment paradigm for structural vocal fold diseases such as scarring and lamina propria loss. This work implants a tissue-engineered replacement for vocal fold lamina propria and epithelium in rabbits and compares histology and function to injured controls and orthotopic transplants. Hypotheses were that the cell-based implant would engraft and control the wound response, reducing fibrosis and restoring vibration.Study Design: Translational research. Methods: Rabbit adipose-derived mesenchymal stem cells (ASC) were embedded within a three-dimensional fibrin gel, forming the cell-based outer vocal fold replacement (COVR). Sixteen rabbits underwent unilateral resection of vocal fold epithelium and lamina propria, as well as reconstruction with one of three treatments: fibrin glue alone with healing by secondary intention, replantation of autologous resected vocal fold cover, or COVR implantation. After 4 weeks, larynges were examined histologically and with phonation.Results: Fifteen rabbits survived. All tissues incorporated well after implantation. After 1 month, both graft types improved histology and vibration relative to injured controls. Extracellular matrix (ECM) of the replanted mucosa was disrupted, and ECM of the COVR implants remained immature. Immune reaction was evident when male cells were implanted into female rabbits. Best histologic and short-term vibratory outcomes were achieved with COVR implants containing male cells implanted into male rabbits.Conclusion: Vocal fold cover replacement with a stem cell-based tissue-engineered construct is feasible and beneficial in acute rabbit implantation. Wound-modifying behavior of the COVR implant is judged to be an important factor in preventing fibrosis.

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“…More than 60 patients have been treated using autologous fat administration in three different studies [63][64][65]79]. Some concerns have been raised about the possibility of administered fat to promote residual tumor cell invasion and metastasis [80]. Preliminary data obtained using head and neck cancer cell lines both in vitro and in vivo suggest that the procedure may be safe, but further investigation performed on patientderived tumor samples is needed [81].…”

Section: Head and Neck Reconstruction After Radiotherapymentioning

confidence: 99%

Regenerative medicine approaches for the management of respiratory tract fistulas

et al. 2020

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Respiratory tract fistulas (or fistulae) are abnormal communications between the respiratory system and the digestive tract or the adjacent organs. The origin can be congenital or, more frequently, iatrogenic and the clinical presentation is heterogeneous. Respiratory tract fistulas can lead to severely reduced health-related quality of life and short survival. Therapy mainly relies on endoscopic surgical interventions but patients often require prolonged hospitalization and may develop complications. Therefore, more conservative regenerative medicine approaches, mainly based on lipotransfer, have also been investigated. Adipose tissue can be delivered either as unprocessed tissue, or after enzymatic treatment to derive the cellular stromal vascular fraction. In the current narrative review, we provide an overview of the main tissue/cell-based clinical studies for the management of various types of respiratory tract fistulas or injuries. Clinical experience is limited, as most of the studies were performed on a small number of patients. Albeit a conclusive proof of efficacy cannot be drawn, the reviewed studies suggest that grafting of adipose tissue-derived material may represent a minimally invasive and conservative treatment option, alternative to more aggressive surgical procedures. Knowledge on safety and tolerability acquired in prior studies can lead to the design of future, larger trials that may exploit innovative procedures for tissue processing to further improve the clinical outcome.

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Human Adipose Tissue-Derived Stromal/Stem Cells Promote Migration and Early Metastasis of Head and Neck Cancer Xenografts

Abstract: Human ASCs did not alter growth of human head/neck cancer cells or tumor xenografts, but stimulated migration and early micrometastasis to mouse brain.

Cited by 32 publications

References 26 publications

Human-derived normal mesenchymal stem/stromal cells in anticancer therapies

Human-derived normal mesenchymal stem/stromal cells in anticancer therapies

Repairing the vibratory vocal fold

Regenerative medicine approaches for the management of respiratory tract fistulas

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