Human Albumin in the Management of Complications of Liver Cirrhosis

Bernardi, Mauro; Maggioli, Caterina; Zaccherini, Giacomo

doi:10.1007/978-3-642-25716-2_39

Cited by 31 publications

(48 citation statements)

References 40 publications

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“…In a previous study, patients with liver cirrhosis had a similar intracerebral hemorrhage incidence rate, but with increased risk of intracerebral hemorrhage during a 9 year follow-up period [12]. Cirrhotic patients are commonly immunocompromised, and coagulopathy and hypoalbuminemia often occur [13][14][15]. These factors may lead to a poor prognosis in cirrhotic patients with HS.…”

Section: Discussionmentioning

confidence: 91%

High mortality in cirrhotic patients following hemorrhagic stroke

Hung¹,

Hsieh²,

Tseng³

et al. 2015

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 91%

High mortality in cirrhotic patients following hemorrhagic stroke

Hung¹,

Hsieh²,

Tseng³

et al. 2015

Journal of Clinical Neuroscience

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“…14,15 This emphasizes the need for early supplemental nutrition and maintenance of serum albumin levels for prompt wound healing and quick recovery. 10,16 With regards to nutrition, enteral nutrition was the most common route preferred in 75% patients with 50% exclusive enteral and 25% partial parenteral nutrition.…”

Section: Discussionmentioning

confidence: 99%

Clinical study of enterocutaneous fistula

Garale¹,

Takalkar²,

Venkatramani³

2017

Int Surg J

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Background: An enterocutaneous fistulae (ECF) may be challenging to manage due to the large volume of fluid losses, that may result in severe dehydration, electrolyte imbalances, malnutrition and sepsis. It is imperative that this group of patients receive adequate nutrition, as malnutrition and sepsis are the leading cause of death.Methods: This descriptive study was conducted prospectively in the Department of Surgery between September 2004 and August 2010. Patients whom develop ECF after surgery were included in the study while patients with esophageal, biliary, pancreatic, and perianal fistulas were excluded. The description of fistula included cause, anatomical location, fistula output, complications, and outcome. Fistula output was quantified by direct measurement, in the presence of drain or by calculating number of dressing pads soaked per day. To examine the statistical significance of association between attributes, Chi-square test and Fisher's exact test were used. A probability value of less than 5% (P < 0.05) was considered significant.Results: A total of 42 patients were included in the study, of which 23 were males and 19 were females and the male:female ratio was 1.2:1. Most patients with ECF were aged 41-50 (mean age, 44.23±2.72). Of the 42 patients, 9 patients had colonic fistula and the remaining had small intestinal fistula; 16 ileal, 5 duodenal, and 12 jejunal. There were 22 patients with high-output fistula as compared to 20 patients with low output fistula. Mortality was significantly higher in patients with males, age >60 years, high-output fistula, mesenteric ischemia as underlying pathology, serum albumin <2.5g/dl and re-surgery.Conclusions: Early diagnosis and stabilization form key aspects of management of ECF as most patients are managed conservatively. Prompt nutritional supplementation alters the outcome of this disease. High output fistulae required mostly surgical management and had high morbidity and mortality.

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“…In fact, a number of studies have indicated the presence of hypoalbuminemia is associated a with poorer prognosis [7,8]. Low albumin levels are often found in patients with liver diseases such as: cirrhosis and chronic hepatitis [9]. Hypoalbuminemia can also result when the kidney is damaged, in which protein is lost through the urine.…”

Section: Protein Bindingmentioning

confidence: 99%

Should Medications be Coadministered with Albumin in Hypoalbuminemic Patients

M¹,

Ellington²,

Akalu³

et al. 2017

J Pharma Care Health Sys

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Protein binding significantly influences pharmacokinetic properties of drug distribution. Albumin accounts for approximately 60% of the total plasma protein by mass, thereby making it the major protein in the body. Hypoalbuminemia, a type of hypoproteinemia, is a condition of abnormally low blood albumin levels. Hypoaluminemia causes pharmacokinetic issues in regards to dosing a patient's medication. The purpose of this paper is to review the role of the coadministration of albumin in hypoalbuminemic patients to optimize pharmacotherapy.

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Human Albumin in the Management of Complications of Liver Cirrhosis

Cited by 31 publications

References 40 publications

High mortality in cirrhotic patients following hemorrhagic stroke

High mortality in cirrhotic patients following hemorrhagic stroke

Clinical study of enterocutaneous fistula

Should Medications be Coadministered with Albumin in Hypoalbuminemic Patients

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