Human amnion-derived mesenchymal stem cells attenuate acute lung injury in two different acute lung injury mice models

Wu, Yuxuan; Sun, Huiling; Qin, Lianju; Zhang, Xiaomin; Zhou, Hui; Wang, Yao; Meng, Ling; Liu, Jiayin; Zhang, Jinsong

doi:10.3389/fphar.2023.1149659

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…MSCs are easily sourced, isolated, and expanded, making them increasingly recognized by healthcare professionals as a valuable source of cell therapies ( Zhuang et al, 2021 ). Using human amnion-derived MSCs, the acute lung injury (ALI) in mice was alleviated by reducing endothelial permeability, oxidative stress, pro-inflammatory mediators, and lung tissue damage ( Wu et al, 2023 ). Alveolar epithelial type II cells (AECIIs) differentiated in vitro from BM progenitor cells alleviated the inflammation and pathological lung tissue damage in a mouse model of ALI ( Ma et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages

Li,

Wen,

Gao

et al. 2024

Front. Cell Dev. Biol.

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Radiation-induced lung injury (RILI) is a common complication of anti-cancer treatments for thoracic and hematologic malignancies. Bone marrow (BM) transplantation restores hematopoietic cell lineages in cancer patients. However, it is ineffective in improving lung repair after RILI due to the paucity of respiratory progenitors in BM transplants. In the present study, we used blastocyst injection to create mouse-rat chimeras, these are artificial animals in which BM is enriched with mouse-derived progenitor cells. FACS-sorted mouse BM cells from mouse-rat chimeras were transplanted into lethally irradiated syngeneic mice, and the contribution of donor cells to the lung tissue was examined using immunostaining and flow cytometry. Donor BM cells provided long-term contributions to all lung-resident hematopoietic cells which includes alveolar macrophages and dendritic cells. Surprisingly, donor BM cells also contributed up to 8% in pulmonary endothelial cells and stromal cells after RILI. To identify respiratory progenitors in donor BM, we performed single-cell RNA sequencing (scRNAseq). Compared to normal mouse BM, increased numbers of hematopoietic progenitors were found in the BM of mouse-rat chimeras. We also identified unique populations of hemangioblast-like progenitor cells expressing Hes1, Dntt and Ebf1, along with mesenchymal stromal cells expressing Cpox, Blvrb and Ermap that were absent or ultra-rare in the normal mouse BM. In summary, by using rats as “bioreactors”, we created a unique mouse BM cell transplant that contributes to multiple respiratory cell types after RILI. Interspecies chimeras have promise for future generations of BM transplants enriched in respiratory progenitor cells.

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Section: Introductionmentioning

confidence: 99%

The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages

Li,

Wen,

Gao

et al. 2024

Front. Cell Dev. Biol.

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Mesenchymal stem cell-based therapy for paraquat-induced lung injury

Zhang,

Li,

2024

Cell Biol Toxicol

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Paraquat poisoning results in significant pulmonary damage, but current treatments are only minimally effective in repairing the injured lung tissues. Recent research has highlighted the promise of using stem cell therapy, namely mesenchymal stem cells, as a new method for treating paraquat toxicity. These cells have shown effectiveness in decreasing inflammation, apoptosis, and fibrosis in the mice lungs subjected to paraquat. The therapeutic implications of mesenchymal stem cells are believed to arise from their release of bioactive proteins and their capacity to regulate inflammatory responses. However, additional clinical study is required to validate these therapies' efficacy. This review thoroughly explores the pathophysiology of paraquat poisoning and the properties of mesenchymal stem cells. Additionally, it critically assesses the long-term safety and effectiveness of mesenchymal stem cell therapies, which is crucial for developing more dependable and effective treatment protocols. In summary, although mesenchymal stem cells offer promising prospects for treating lung injuries, more investigations are required to optimize their therapeutic promise and ensure their safe clinical application in the context of paraquat poisoning. Supplementary Information The online version contains supplementary material available at 10.1007/s10565-024-09911-3.

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Systemic meta-analysis: apigenin’s effects on lung inflammation and oxidative stress

Wang,

Xiao,

Zhang

et al. 2023

Journal of Asthma

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Human amnion-derived mesenchymal stem cells attenuate acute lung injury in two different acute lung injury mice models

Cited by 3 publications

References 40 publications

The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages

The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages

Mesenchymal stem cell-based therapy for paraquat-induced lung injury

Systemic meta-analysis: apigenin’s effects on lung inflammation and oxidative stress

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