Human amnion in the treatment of vaginal malformations

Morton, Karen; Dewhurst, C. J.

doi:10.1111/j.1471-0528.1986.tb07813.x

Cited by 59 publications

(29 citation statements)

References 9 publications

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“…The HAM can produce a wide array of growth factors and provide a healthy new substrate suitable for re-epithelization and epithelial healing (Wilshaw et al 2006). Amnion allografts are widely applied in ophthalmology, plastic surgery, dermatology, and gynecology Santos et al 2005;Rinastiti et al 2006;Meller et al 2000;Morton and Dewhurst 1986). The low cost of amnion graft preparation and the very good clinical results in multipurpose applications have made it a valuable material for tissue banking and a viable alternative to other natural (i.e., preserved human skin) and synthetic wound dressings.…”

Section: Discussionmentioning

confidence: 99%

Potential use of the human amniotic membrane as a scaffold in human articular cartilage repair

et al. 2010

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The human amniotic membrane (HAM) is an abundant and readily obtained tissue that may be an important source of scaffold for transplanted chondrocytes in cartilage regeneration in vivo. To evaluate the potential use of cryopreserved HAMs as a support system for human chondrocytes in human articular cartilage repair. Chondrocytes were isolated from human articular cartilage, cultured and grown on the chorionic basement membrane side of HAMs. HAMs with chondrocytes were then used in 44 in vitro human osteoarthritis cartilage repair trials. Repair was evaluated at 4, 8 and 16 weeks by histological analysis. Chondrocytes cultured on the HAM revealed that cells grew on the chorionic basement membrane layer, but not on the epithelial side. Chondrocytes grown on the chorionic side of the HAM express type II collagen but not type I, indicating that after being in culture for 3-4 weeks they had not de-differentiated into fibroblasts. In vitro repair experiments showed formation on OA cartilage of new tissue expressing type II collagen. Integration of the new tissue with OA cartilage was excellent. The results indicate that cryopreserved HAMs can be used to support chondrocyte proliferation for transplantation therapy to repair OA cartilage.

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Section: Discussionmentioning

confidence: 99%

Potential use of the human amniotic membrane as a scaffold in human articular cartilage repair

et al. 2010

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“…Use of an amnion graft to cover the newly created vaginal space has been associated with very good outcome (preservation of a functional vaginal space) ranging from 88 to 100% [127,[135][136][137][138][139][140]. However, in the past years, concerns have been raised regarding the potential transmission of infectious agents such as hepatitis and HIV, and therefore, the method has been abandoned [141].…”

Section: The Mcindoe Operationmentioning

confidence: 99%

Mullerian dysgenesis: a critical review of the literature

Choussein

Nasioudis

Schizas

et al. 2017

Arch Gynecol Obstet

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“…On the other hand, HAM has abundant natural cartilage components, which are important in the regulation and maintenance of normal chondrocyte metabolism (Jin et al, 2007); this suggests that the HAM is an excellent candidate for use as native scaffold for cartilage tissue engineering (Niknejad et al, 2008). Amnion allografts are widely applied in ophthalmology, plastic surgery, dermatology, and gynecology (Tejwani et al, 2007;Santos et al, 2005;Rinastiti et al, 2006;Meller et al, 2000;Morton & Dewhurst, 1986). A recent study demonstrated the potential use of the HAM as a scaffold to support human chondrocyte proliferation in cell therapy to repair human OA cartilage (Díaz-Prado et al, 2010c).…”

Section: Scaffoldsmentioning

confidence: 99%