Human and Animal Isolates of Yersinia enterocolitica Show Significant Serotype-Specific Colonization and Host-Specific Immune Defense Properties

Schaake, Julia; Kronshage, Malte; Uliczka, Frank; Rohde, Manfred; Knuuti, Tobias; Strauch, Eckhard; Fruth, Angelika; Wos‐Oxley, Melissa L.; Dersch, Petra

doi:10.1128/iai.00572-13

Cited by 15 publications

(15 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, it has been documented that IL-10 can provide beneficial effects for pathogenic bacteria, enabling the pathogen to circumvent the defenses of the host [38]. In infections with Y. enterocolitica, IL-10 can both impede pathogen clearance and ameliorate immunopathology [39]. In our study, all inoculations with bacteria (fermented milk, C4 or Y. enterocolitica) resulted in significant reductions in IL-10 levels in cecal contents, but C4 pretreatment did not modify the production of IL-10 in response to infection with Y. enterocolitica.…”

Section: Discussionmentioning

confidence: 98%

A Lactobacillus plantarum strain isolated from kefir protects against intestinal infection with Yersinia enterocolitica O9 and modulates immunity in mice

Montijo-Prieto

Moreno

Bergillos-Meca

et al. 2015

Research in Microbiology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

A Lactobacillus plantarum strain isolated from kefir protects against intestinal infection with Yersinia enterocolitica O9 and modulates immunity in mice

Montijo-Prieto

Moreno

Bergillos-Meca

et al. 2015

Research in Microbiology

View full text Add to dashboard Cite

“…One hour before infection, the culture medium was replaced as previously described [38]. Overnight cultures of bacteria grown in LB medium at 25°C were washed with PBS and added to the J774A.1 macrophages in a multiplicity of infection (MOI) of 1 or 10.…”

Section: Methodsmentioning

confidence: 99%

Influence of PhoP and Intra-Species Variations on Virulence of Yersinia pseudotuberculosis during the Natural Oral Infection Route

et al. 2014

Self Cite

View full text Add to dashboard Cite

The two-component regulatory system PhoP/PhoQ has been shown to (i) control expression of virulence-associated traits, (ii) confer survival and growth within macrophages and (iii) play a role in Yersinia infections. However, the influence of PhoP on virulence varied greatly between different murine models of infection and its role in natural oral infections with frequently used representative isolates of Y. pseudotuberculosis was unknown. To address this issue, we constructed an isogenic set of phoP + and phoP − variants of strain IP32953 and YPIII and analyzed the impact of PhoP using in vitro functionality experiments and a murine oral infection model, whereby we tested for bacterial dissemination and influence on the host immune response. Our results revealed that PhoP has a low impact on virulence, lymphatic and systemic organ colonization, and on immune response modulation by IP32953 and YPIII, indicating that PhoP is not absolutely essential for oral infections but may be involved in fine-tuning the outcome. Our work further revealed certain strain-specific differences in virulence properties, which do not strongly rely on the function of PhoP, but affect tissue colonization, dissemination and/or persistence of the bacteria. Highlighted intra-species variations may provide a potential means to rapidly adjust to environmental changes inside and outside of the host.

show abstract

“…Yersinia enterocolitica is a Gram-negative bacterial pathogen and the causative agent of yersiniosis in humans (1). Infection is frequently associated with the consumption of contaminated foods (2), including pork, which is considered to be the main source of the pathogen (3), beef, cow’s milk, and poultry, as well as raw vegetables (4).…”

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequences of Four Yersinia enterocolitica Strains, Isolated from Wild Ungulate Carcasses

et al. 2017

View full text Add to dashboard Cite

show abstract

Human and Animal Isolates of Yersinia enterocolitica Show Significant Serotype-Specific Colonization and Host-Specific Immune Defense Properties

Cited by 15 publications

References 65 publications

A Lactobacillus plantarum strain isolated from kefir protects against intestinal infection with Yersinia enterocolitica O9 and modulates immunity in mice

A Lactobacillus plantarum strain isolated from kefir protects against intestinal infection with Yersinia enterocolitica O9 and modulates immunity in mice

Influence of PhoP and Intra-Species Variations on Virulence of Yersinia pseudotuberculosis during the Natural Oral Infection Route

Draft Genome Sequences of Four Yersinia enterocolitica Strains, Isolated from Wild Ungulate Carcasses

Contact Info

Product

Resources

About