Human and Veterinary Anthelmintics (1965–71)

Combination therapy in the treatment of helminth diseases

“…in pigs. In another trial, piperazine (100 mgkg) and 5 (100 mgkg) was given to sows (dose not exceeding 10 g/animal) for 2 days carrying mixed infections of Ascaris and Oesophugostornurn gave good results.21 A combination of piperazine salt either with sodium silicofluoride2* or sodium fluosilicate and suiverm, a mixture of diethylcarbamazine (6) and thiabendazole (4)= has been used to control Ascuris The Ascuris infestation in poultry has been treated using a number of piperazine combinations. Thus a mixture of piperazine adipate (162.5 mg) and haloxon (7) (15.4 mg) controlled Cupillaria obsignatu and Ascuridiu colurnbue in pigeons.= Similarly administration of a mixture of 0.2 g k g of niclosamide (phenasal, 8) with a similar dose of piperazine dithiocarbamate given twice, 24 hr apart, freed 2004 adult chickens from various intestinal nematodes.…”

“…in pigs. In another trial, piperazine (100 mgkg) and 5 (100 mgkg) was given to sows (dose not exceeding 10 g/animal) for 2 days carrying mixed infections of Ascaris and Oesophugostornurn gave good results.21 A combination of piperazine salt either with sodium silicofluoride2* or sodium fluosilicate and suiverm, a mixture of diethylcarbamazine (6) and thiabendazole (4)= has been used to control Ascuris…”

“…In Brazil, a combination of 1 with pyrvinium or thiabendazole has been evaluated in several patients. A 5 ml measure containing 37.5 mg of pyrvinium pamoate (20) and 40.6 mg of tetramisole cyclamate given in [4][5][6] measures in single dose produced 8040% activity against Ascuris and Enterobius infections present singly or in mixed form in man.& A mixture of tetramisole (2.5-3.0 mgkg) and thiabendazole (25-30 mgkg) given for 3 consecutive days to 40 patients with mixed helminth infections produced 87, 100 and 77% cures against Ascaris, Enterobius and Strongyloides re~pectively.~~…”

Bisphenol flukicides. I. Crystal structures of 2,2'-ethylidenebis(4-chloro-6-nitrophenol) and 2,2'-isopropylidenebis(4-chloro-6-nitrophenol)

“…for Fasciola hepatica (liver-fluke) infection in sheep and cattle (Burrows, 1973). Menichlopholan uncouples oxidative phosphorylation in warm-blooded animals (van Miert & Groeneveld, 1969) and it is probable that the effectiveness of the compound against liver-flukes is due to the same effect.…”

“…In the ethane structure, the CI atoms lie on the same side of the molecular skeleton and the dihedral angle between the phenyl rings is 92.4 °. In the isopropane structure, however, the phenyl rings are mutually inclined at 77.4 ° and the CI atoms lie on opposite sides of the molecular skeleton which has twofold symmetry.Introduction 5,5'-Dichloro-3,3'-dinitro-2,2'-biphenyldiol (I), otherwise known as menichlopholan, is an effective curative 0567-7408/79/122952-06501.00for Fasciola hepatica (liver-fluke) infection in sheep and cattle (Burrows, 1973). Menichlopholan uncouples oxidative phosphorylation in warm-blooded animals (van Miert & Groeneveld, 1969) and it is probable that the effectiveness of the compound against liver-flukes is due to the same effect.…”