Human and yeast ζ-crystallins bind AU-rich elements in RNA

Fernández, María Rosario Salinas; Porté, Sergio; Crosas, Eva; Barbera, Nunziata; Farrés, Jaume; Biosca, Josep A.; Parés, Xavier

doi:10.1007/s00018-007-7091-1

Cited by 36 publications

(42 citation statements)

References 25 publications

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“…Galectin-3 expression is under the control of the AP1 transcription factor and NFκB, a proinflammatory transcription factor [59], and it is involved in monocyte chemotaxis [60], activation of NADPH oxidase [61,62] , phagocytosis [63], and ROS release [64] (FIG. 1).…”

Section: Galectin-3mentioning

confidence: 99%

Novel Neuroinflammatory Targets in the Chronically Injured Spinal Cord

Pajoohesh‐Ganji

Byrnes

2011

Neurotherapeutics

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Summary: Injury to the spinal cord is known to result in inflammation. To date, the preponderance of research has focused on the acute neuroinflammatory response, which begins immediately and is believed to terminate within hours to (at most) days after the injury. However, recent studies have demonstrated that postinjury inflammation is not restricted to the first few hours or days after injury, but can last for months to years after a spinal cord injury (SCI). These chronic studies have revealed that increased numbers of inflammatory cells, such as microglia and macrophages, and inflammatory factors, including cytokines, chemokines, and enzyme products are found at markedly delayed times after injury. Here we review experimental work on a selection of the novel inflammatory factors observed chronically after SCI, including the nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) oxidase enzyme and galectin-3. We will discuss the role of these proteins in inflammation with regard to both detrimental and beneficial effects of neuroinflammation after injury. Finally, the potential of these proteins to serve as therapeutic targets will be considered, and a novel therapeutic approach (i.e., the agonist for metabotropic glutamate receptor 5 [mGluR5], [RS]-2-Chloro-5-hydroxyphenylglycine [CHPG]) will be discussed. This review will demonstrate the expression and activity profiles, roles in potentiation of injury, and therapy studies of these inflammatory factors suggest that not only are these chronically expressed factors viable targets for SCI treatment, but that the therapeutic window is broader than has previously been thought.

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Section: Galectin-3mentioning

confidence: 99%

Novel Neuroinflammatory Targets in the Chronically Injured Spinal Cord

Pajoohesh‐Ganji

Byrnes

2011

Neurotherapeutics

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“…It may act as trans-acting factor in mRNA regulation [85][86][87][88]. The role of TYW3 and NDST4 is not yet clear [85].…”

Section: Resistin (Retn)mentioning

confidence: 99%

Genetic Determination of Serum Levels of Diabetes-Associated Adipokines

Schleinitz¹

2016

Rev Diabet Stud

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■ AbstractAdipose tissue secretes an abundance of proteins. Some of these proteins are known as adipokines and adipose-derived hormones which have been linked with metabolic disorders, including type 2 diabetes, and even with cancer. Variance in serum adipokine concentration is often closely associated with an increase (obesity) or decrease (lipodystrophy) in fat tissue mass, and it is affected by age, gender, and localization of the adipose tissue. However, there may be genetic variants which, in consequence, influence the serum concentration of a certain adipokine, and thereby promote metabolic disturbances or, with regard to the "protective" allele, exert beneficial effects. This review focuses on the genetic determination of serum levels of the following adipokines: adiponectin, chemerin, leptin, progranulin, resistin, retinol binding protein 4, vaspin, adipsin, apelin, and omentin. The article reports on the latest findings from genome-wide association studies (GWAS) and candidate gene studies, showing variants located in/nearby the adipokine genes and other (non-receptor) genes. An extra chapter highlights adipokine-receptor variants. Epigenetic studies on adipokines are also addressed.

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“…The recently-found yeast -crystalline (ZTAIp), an RNA-binding protein [34], and bovine serum albumin (BSA) were used as positive and negative controls, respectively (Fig. 7).…”

Section: Rna Electrophoretic Mobility Shift Assays (Emsa)mentioning

confidence: 99%

Prediction of a new class of RNA recognition motif

Cerdà-Costa¹,

Bonet²,

Fernández³

et al. 2010

J Mol Model

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The observation that activation domains (AD) of procarboxypeptidases are rather long, compared to pro-regions of other zymogens, points out the possibility that they could play additional roles apart from precluding enzymatic activity within the proenzyme and helping in its folding process. In the present work, we have compared the overall pro-domain tertiary structure with several proteins belonging to the same fold in SCOP by using structure and sequence comparisons. The best score has been obtained between the activation domain of the human procarboxypeptidase A4 (ADA4h) and the human U1A protein from the U1 snRNP.Structural alignment has revealed the existence of RNP1-and RNP2-related sequences in ADA4h. After modeling ADA4h on U1A, the new structure was used to extract a new sequence pattern characteristic for important residues at key positions. The new sequence pattern allowed scanning protein sequences to predict the RNA-binding function for 32 sequences undetected by PFAM. Unspecific RNA EMSA experimentally supported the prediction that ADA4h binds an RNA motif similar to the U1A binding-motif of stem-loop II of U1 small nuclear RNA. The experiments carried out with ADA4h in the present work Manuscript Click here to download Manuscript: JMMO1391R2_final.doc 2 suggest the sharing of a common ancestor with other RRMs. However, the fact that key residues preventing activity within the proenzyme are also key residues for RNA binding might induce the activation domains of procarboxypeptidases to evolve from the canonical RNP1 and 2 sequences.

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Human and yeast ζ-crystallins bind AU-rich elements in RNA

Cited by 36 publications

References 25 publications

Novel Neuroinflammatory Targets in the Chronically Injured Spinal Cord

Novel Neuroinflammatory Targets in the Chronically Injured Spinal Cord

Genetic Determination of Serum Levels of Diabetes-Associated Adipokines

Prediction of a new class of RNA recognition motif

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