Human aortic atherosclerotic plaque characterisation under acoustic radiation force impulse using fluid-structural-interface simulations

Lin, Kexin; Li, Han; Shahmirzadi, Danial

doi:10.1504/ijbet.2017.083819

Cited by 1 publication

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“…39,40 It should be again noted that the present study was established based on the idealized aneurysm geometry with a simple one-layer aortic wall. Future studies are needed in order to examine the wave dynamics on patient-specific aneurysmal geometries with various diameters of the sac and bifurcations, and with aortic wall composed of intima/media/ adventitia layers and thrombus, such as those developed by Lin et al 64 The accuracy of the results may also be improved by using more physiologically relevant modeling parameters such as material properties and input/boundary conditions. Other studies have shown that modeling the arterial wall as porous, 47 viscoelastic, nonlinear, inhomogeneous, 52 and anisotropic 50 and the fluid as viscous, 55 incompressible, and non-Newtonian 54 affects the FSI dynamics and results in different outputs on the fluid such as shear stress and pressure.…”

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confidence: 99%

FSI Simulations of Pulse Wave Propagation in Human Abdominal Aortic Aneurysm: The Effects of Sac Geometry and Stiffness

Lin

Shahmirzadi

2016

Biomed Eng Comput Biol

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This study aims to quantify the effects of geometry and stiffness of aneurysms on the pulse wave velocity (PWV) and propagation in fluid–solid interaction (FSI) simulations of arterial pulsatile flow. Spatiotemporal maps of both the wall displacement and fluid velocity were generated in order to obtain the pulse wave propagation through fluid and solid media, and to examine the interactions between the two waves. The results indicate that the presence of abdominal aortic aneurysm (AAA) sac and variations in the sac modulus affect the propagation of the pulse waves both qualitatively (eg, patterns of change of forward and reflective waves) and quantitatively (eg, decreasing of PWV within the sac and its increase beyond the sac as the sac stiffness increases). The sac region is particularly identified on the spatiotemporal maps with a region of disruption in the wave propagation with multiple short-traveling forward/reflected waves, which is caused by the change in boundary conditions within the saccular region. The change in sac stiffness, however, is more pronounced on the wall displacement spatiotemporal maps compared to those of fluid velocity. We conclude that the existence of the sac can be identified based on the solid and fluid pulse waves, while the sac properties can also be estimated. This study demonstrates the initial findings in numerical simulations of FSI dynamics during arterial pulsations that can be used as reference for experimental and in vivo studies. Future studies are needed to demonstrate the feasibility of the method in identifying very mild sacs, which cannot be detected from medical imaging, where the material property degradation exists under early disease initiation.

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