2016
DOI: 10.1016/j.bbrc.2016.09.078
|View full text |Cite
|
Sign up to set email alerts
|

Human aortic smooth muscle cell-derived exosomal miR-221/222 inhibits autophagy via a PTEN/Akt signaling pathway in human umbilical vein endothelial cells

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
30
0
1

Year Published

2017
2017
2023
2023

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 58 publications
(32 citation statements)
references
References 21 publications
1
30
0
1
Order By: Relevance
“…So far, several miRNAs involved in endothelial dysfunction through autophagy detection have been reported. miR‐221/222 from normal human aortic smooth muscle cell (HAoSMC)‐derived exosomes have been shown to inhibit autophagy in human umbilical vein endothelial cells (HUVECs) by modulating the PTEN/AKT signalling pathway . Furthermore, miR‐30 and miR‐129 are shown to modulate endothelial autophagy by targeting ATG‐6 and beclin‐1 respectively .…”
Section: Introductionmentioning
confidence: 99%
“…So far, several miRNAs involved in endothelial dysfunction through autophagy detection have been reported. miR‐221/222 from normal human aortic smooth muscle cell (HAoSMC)‐derived exosomes have been shown to inhibit autophagy in human umbilical vein endothelial cells (HUVECs) by modulating the PTEN/AKT signalling pathway . Furthermore, miR‐30 and miR‐129 are shown to modulate endothelial autophagy by targeting ATG‐6 and beclin‐1 respectively .…”
Section: Introductionmentioning
confidence: 99%
“…Overexpression of p27 is found to rescue the impairment of miR-221 on autophagic flux in cardiac remodeling (10). In human umbilical vein endothelial cells, miR-221 is found to inhibit autophagy by modulating a PTEN/Akt signaling pathway (12). miR-221 targeting PTEN/Akt is also reported in several cancer cells during cancer development (33)(34)(35).…”
Section: Discussionmentioning
confidence: 94%
“…Upregulation of miR-221 is also found to inhibit hypoxia/re-oxygenation induced autophagy (11). Inhibition of autophagy by miR-221 in human umbilical vein endothelial cells is further reported (12). Although miR-221 is found to regulate autophagic gene in cancer (13), no direct evidence suggests a role of miR-221 in cancer related autophagy (14).…”
Section: Mir-221 Inhibits Autophagy and Targets Tp53inp1mentioning
confidence: 99%
“…L'autophagie endothéliale -en nettoyant et recyclant des composants des cellules tapissant la paroi vasculaire -exerce un rôle protecteur limitant le développement des plaques athéromateuses. Des travaux récents ont mis en évidence une altération de la machinerie autophagique endothéliale par des VE dérivées de cellules musculaires lisses aortiques, capables de moduler l'expression d'acteurs clé de l'autophagie par transfert exosomal de micro-ARN [43]. Les VE dérivées de cellules immunitaires pourraient aussi contribuer à entretenir et amplifier la réponse inflammatoire associée à l'athérosclérose.…”
Section: Référencesunclassified