Human Auditory and Adjacent Nonauditory Cerebral Cortices Are Hypermetabolic in Tinnitus as Measured by Functional Near-Infrared Spectroscopy (fNIRS)

Issa, Mohamad; Bisconti, Silvia; Kovelman, Ioulia; Kileny, Paul R.; Basura, Gregory J.

doi:10.1155/2016/7453149

Cited by 28 publications

(50 citation statements)

References 63 publications

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“…Tinnitus has previously been regarded as one of the coexistent symptoms of auditory system disorders [5-10] or as an early sign of subtle cerebral infarction [11, 12]. In this study, we found that the risk of brain tumors, especially benign ones, was significantly higher in patients with tinnitus compared with those without the condition.…”

Section: Discussionsupporting

confidence: 46%

“…Subjective tinnitus is believed to originate from the cochlear and/or central nervous system dysfunction at the levels of the brainstem, subcortical and cortical level, as well as the limbic system [5, 6]. Subjective tinnitus is a symptom that is typically associated with otologic disorders, such as sensorineural hearing loss caused by excessive noise, ototoxic medication use, or Ménière’s disease as well as conductive hearing loss caused by ear infection or middle ear effusion [7].…”

Section: Introductionmentioning

confidence: 99%

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Tinnitus Is Associated with a Higher Risk of Benign Brain Tumors: A Nationwide, Population-Based Secondary Cohort Study of Young and Middle-Aged Adults

Chen¹,

Koo

Hwang

2017

Neuroepidemiology

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Background: It remains unclear whether tinnitus is associated with a higher risk of benign or malignant brain tumors in humans. Therefore, the aim of this secondary study was to investigate the risk of brain tumors in adult with tinnitus using data from a nationwide health claims research database. Methods: Patients aged 20–50 years who were newly diagnosed with tinnitus were identified from the Taiwan’s National Health Insurance Research Database and they served as the study cohort. A comparison cohort was formed by using patients without tinnitus from the same database with frequency matching (4: 1) by 10-year age interval and gender to the patients in the tinnitus cohort. Cox proportional hazards models were used to calculate the adjusted hazard ratios (AHR) for benign and malignant brain tumors in patients with tinnitus, adjusting for age, gender, and comorbidities. Results: There were 15,819 patients in the tinnitus cohort and 63,276 in the comparison cohort. A significantly higher proportion of patients with tinnitus had benign brain tumor (p = 0.003) and all 11 comorbid conditions (p < 0.001) compared to those without tinnitus. Cox proportional hazards regression analysis performed on the basis of age, gender, and the 11 comorbidities revealed that tinnitus was independently associated with a higher risk for benign brain tumor (AHR 1.65, 95% CI 1.24–2.20, p = 0.001) and but not with malignant brain tumors (AHR 1.66, 95% CI 0.93–2.94, p = 0.085). Conclusions: Findings from this secondary cohort analysis indicated that tinnitus is associated with a higher risk of benign brain tumors.

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Section: Discussionsupporting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Tinnitus Is Associated with a Higher Risk of Benign Brain Tumors: A Nationwide, Population-Based Secondary Cohort Study of Young and Middle-Aged Adults

Chen¹,

Koo

Hwang

2017

Neuroepidemiology

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“…A number of studies have recently used fNIRS in participants with tinnitus to record brain activity at rest or in response to sound, showing sensitivity of fNIRS to detect tinnitus-related neural activity [5,[22][23][24]. Resting state data can be used to derive measures of connectivity between different regions of the brain.…”

Section: Introductionmentioning

confidence: 99%

Objective measurement of tinnitus using functional near-infrared spectroscopy and machine learning

et al. 2020

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Chronic tinnitus is a debilitating condition which affects 10–20% of adults and can severely impact their quality of life. Currently there is no objective measure of tinnitus that can be used clinically. Clinical assessment of the condition uses subjective feedback from individuals which is not always reliable. We investigated the sensitivity of functional near-infrared spectroscopy (fNIRS) to differentiate individuals with and without tinnitus and to identify fNIRS features associated with subjective ratings of tinnitus severity. We recorded fNIRS signals in the resting state and in response to auditory or visual stimuli from 25 individuals with chronic tinnitus and 21 controls matched for age and hearing loss. Severity of tinnitus was rated using the Tinnitus Handicap Inventory and subjective ratings of tinnitus loudness and annoyance were measured on a visual analogue scale. Following statistical group comparisons, machine learning methods including feature extraction and classification were applied to the fNIRS features to classify patients with tinnitus and controls and differentiate tinnitus at different severity levels. Resting state measures of connectivity between temporal regions and frontal and occipital regions were significantly higher in patients with tinnitus compared to controls. In the tinnitus group, temporal-occipital connectivity showed a significant increase with subject ratings of loudness. Also in this group, both visual and auditory evoked responses were significantly reduced in the visual and auditory regions of interest respectively. Naïve Bayes classifiers were able to classify patients with tinnitus from controls with an accuracy of 78.3%. An accuracy of 87.32% was achieved using Neural Networks to differentiate patients with slight/ mild versus moderate/ severe tinnitus. Our findings show the feasibility of using fNIRS and machine learning to develop an objective measure of tinnitus. Such a measure would greatly benefit clinicians and patients by providing a tool to objectively assess new treatments and patients’ treatment progress.

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“…Tinnitus is a common complex disease and often results from auditory dysfunction, although many other etiologies were reported 1 . Some mechanisms including the neural receptor theory were proposed in these decades.…”

Section: Introductionmentioning

confidence: 99%

Effects of Spirulina on GABA-Receptor Gene Expression in Salicylate-Induced Tinnitus

Chan

Wang

Hwang³

2018

The International Tinnitus Journal

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Human Auditory and Adjacent Nonauditory Cerebral Cortices Are Hypermetabolic in Tinnitus as Measured by Functional Near-Infrared Spectroscopy (fNIRS)

Cited by 28 publications

References 63 publications

Tinnitus Is Associated with a Higher Risk of Benign Brain Tumors: A Nationwide, Population-Based Secondary Cohort Study of Young and Middle-Aged Adults

Tinnitus Is Associated with a Higher Risk of Benign Brain Tumors: A Nationwide, Population-Based Secondary Cohort Study of Young and Middle-Aged Adults

Objective measurement of tinnitus using functional near-infrared spectroscopy and machine learning

Effects of Spirulina on GABA-Receptor Gene Expression in Salicylate-Induced Tinnitus

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