Human beta-defensin 1, 2 and 3 production by amniotic epithelial cells with respect to human papillomavirus (HPV) infection, HPV oncogenic potential and the mode of delivery

Szukiewicz, Dariusz; Alkhalayla, Habib; Pyźlak, Michał; Wątroba, Mateusz; Szewczyk, Grzegorz; Wejman, Jarosław

doi:10.1016/j.micpath.2016.06.010

Cited by 15 publications

(15 citation statements)

References 53 publications

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“…HPV infection also increased hBD-1 to -3 expression in oral epithelial lesions from patients with recurrent respiratory papillomatosis (Chong et al, 2006). hBD production was then demonstrated in vulvovaginal biopsy samples of condylomata acuminata as well as in human amniotic epithelial cells infected with HPV (Erhart et al, 2011;Szukiewicz et al, 2016). Interestingly, expression of hBD-2 was paradoxically diminished in HPV-induced carcinomas potentially defining a mechanism of virus escape to the host immune response occurring during carcinogenesis (Hubert et al, 2007).…”

Section: β-Defensinsmentioning

confidence: 96%

Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes

et al. 2020

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Keratinocytes, the main cells of the epidermis, are the first site of replication as well as the first line of defense against many viruses such as arboviruses, enteroviruses, herpes viruses, human papillomaviruses, or vaccinia virus. During viral replication, these cells can sense virus associated molecular patterns leading to the initiation of an innate immune response composed of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. Human keratinocytes produce and secrete at least nine antimicrobial peptides: human cathelicidin LL-37, types 1-4 human β-defensins, S100 peptides such as psoriasin (S100A7), calprotectin (S100A8/9) and koebnerisin (S100A15), and RNase 7. These peptides can exert direct antiviral effects on the viral particle or its replication cycle, and indirect antiviral activity, by modulating the host immune response. The purpose of this review is to summarize current knowledge of antiviral and immunomodulatory properties of human keratinocyte antimicrobial peptides.

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Section: β-Defensinsmentioning

confidence: 96%

Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes

et al. 2020

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“…Unsurprisingly, the expression of several AMPs is induced in the case of intra-amniotic infection or inflammation (Figure 1). Among the most prominent AMPs are human β-defensins (HBD)1-3, which are expressed by multiple cells of hACM and are also found in the hAF (King et al, 2007a,b;Soto et al, 2007;Szukiewicz et al, 2016;Varrey et al, 2018;Para et al, 2020). Human neutrophil peptides (HNP)1-3, which also belong to the α defensin group, are present in the hAF of uncomplicated pregnancies but are more abundant during inflammation (Heine et al, 1998;Espinoza et al, 2003;Yoshio et al, 2003;Akinbi et al, 2004;Buhimschi et al, 2005).…”

Section: Antimicrobial Peptides In Fetal Membranesmentioning

confidence: 99%

Antimicrobial Activity of Human Fetal Membranes: From Biological Function to Clinical Use

Ramuta

Sket

Erjavec

et al. 2021

Front. Bioeng. Biotechnol.

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The fetal membranes provide a supportive environment for the growing embryo and later fetus. Due to their versatile properties, the use of fetal membranes in tissue engineering and regenerative medicine is increasing in recent years. Moreover, as microbial infections present a crucial complication in various treatments, their antimicrobial properties are gaining more attention. The antimicrobial peptides (AMPs) are secreted by cells from various perinatal derivatives, including human amnio-chorionic membrane (hACM), human amniotic membrane (hAM), and human chorionic membrane (hCM). By exhibiting antibacterial, antifungal, antiviral, and antiprotozoal activities and immunomodulatory activities, they contribute to ensuring a healthy pregnancy and preventing complications. Several research groups investigated the antimicrobial properties of hACM, hAM, and hCM and their derivatives. These studies advanced basic knowledge of antimicrobial properties of perinatal derivatives and also provided an important insight into the potential of utilizing their antimicrobial properties in a clinical setting. After surveying the studies presenting assays on antimicrobial activity of hACM, hAM, and hCM, we identified several considerations to be taken into account when planning future studies and eventual translation of fetal membranes and their derivatives as antimicrobial agents from bench to bedside. Namely, (1) the standardization of hACM, hAM, and hCM preparation to guarantee rigorous antimicrobial activity, (2) standardization of the antimicrobial susceptibility testing methods to enable comparison of results between various studies, (3) investigation of the antimicrobial properties of fetal membranes and their derivatives in the in vivo setting, and (4) designation of donor criteria that enable the optimal donor selection. By taking these considerations into account, future studies will provide crucial information that will enable reaching the optimal treatment outcomes using the fetal membranes and their derivatives as antimicrobial agents.

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“…Similarly, elevated hBD2 at the time of amniocentesis was positively associated with increased likelihood of preterm birth (83). Human papillomavirus has also been shown to upregulate β-defensin expression by amniotic epithelial cells (84), hinting at an integral ubiquitous protective role for these molecules during pregnancy. In addition to the prenatal microbiome, a prokaryotic “top up” occurs via inoculation from the birth canal during the birth process.…”

Section: Farmers Of the Microbiomementioning

confidence: 99%

β-Defensins: Farming the Microbiome for Homeostasis and Health

2019

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Diverse commensal populations are now regarded as key to physiological homeostasis and protection against disease. Although bacteria are the most abundant component of microbiomes, and the most intensively studied, the microbiome also consists of viral, fungal, archael, and protozoan communities, about which comparatively little is known. Host-defense peptides (HDPs), originally described as antimicrobial, now have renewed significance as curators of the pervasive microbial loads required to maintain homeostasis and manage microbiome diversity. Harnessing HDP biology to transition away from non-selective, antibiotic-mediated treatments for clearance of microbes is a new paradigm, particularly in veterinary medicine. One family of evolutionarily conserved HDPs, β-defensins which are produced in diverse combinations by epithelial and immune cell populations, are multifunctional cationic peptides which manage the cross-talk between host and microbes and maintain a healthy yet dynamic equilibrium across mucosal systems. They are therefore key gatekeepers to the oral, respiratory, reproductive and enteric tissues, preventing pathogen-associated inflammation and disease and maintaining physiological normality. Expansions in the number of genes encoding these natural antibiotics have been described in the genomes of some species, the functional significance of which has only recently being appreciated. β-defensin expression has been documented pre-birth and disruptions in their regulation may play a role in maladaptive neonatal immune programming, thereby contributing to subsequent disease susceptibility. Here we review recent evidence supporting a critical role for β-defensins as farmers of the pervasive and complex prokaryotic ecosystems that occupy all body surfaces and cavities. We also share some new perspectives on the role of β-defensins as sensors of homeostasis and the immune vanguard particularly at sites of immunological privilege where inflammation is attenuated.

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Human beta-defensin 1, 2 and 3 production by amniotic epithelial cells with respect to human papillomavirus (HPV) infection, HPV oncogenic potential and the mode of delivery

Cited by 15 publications

References 53 publications

Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes

Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes

Antimicrobial Activity of Human Fetal Membranes: From Biological Function to Clinical Use

β-Defensins: Farming the Microbiome for Homeostasis and Health

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