Human-Biomonitoring für Europa (HBM4EU) – erste Einblicke in die Ergebnisse der Initiative

Weise, Philipp; Apel, Petra; Kolossa-Gehring, Marike

doi:10.1007/s00103-022-03578-z

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Regarding the extrapolation of population-based results to the clinic, it should be taken into account that even moderate disturbances in the hormonal milieu can have relevant effects, particularly during fetal development. ,,, Additionally, exposure to phthalates and their replacements is pervasive, with virtually all human populations showing quantifiable levels. – In this setting, small shifts in the mean of a distribution can produce large effects in their tails. – …”

Section: Discussionmentioning

confidence: 99%

“…13 Despite some regulations in Europe, recent birth cohorts and biomonitoring studies show that phthalate exposure is still widespread, with more than 90% of the European population showing detectable concentrations in urine. 14,15 In addition, newer phthalates such as bis(2-propylheptyl) phthalate (DPHP) and the nonphthalate substitute 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) have recently entered the market, showing increasing concentrations in humans over time. 14,16 Since these new chemicals have a similar structure to those they replace and could potentially exert deleterious effects, 17,18 there is a need for continuous biomonitoring and surveillance.…”

Section: Introductionmentioning

confidence: 99%

“…High molecular weight phthalates (>250 Da; ester side-chain lengths of five or more carbons) are employed as plasticizers in the production of polyvinyl chloride plastics and are found in a variety of products, such as food contact materials, building and construction materials (e.g., vinyl flooring, floor tiles, wall coverings, and furniture upholstery), medical devices (tubing, catheters, blood/dialysis bags), and toys. , Low-molecular-weight phthalates (<250 Da; ester side-chain lengths of one to four carbons) are used as solubilizing agents in the formulation of cosmetics and personal care products (e.g., fragrances) and as coatings of some pharmaceuticals . Despite some regulations in Europe, recent birth cohorts and biomonitoring studies show that phthalate exposure is still widespread, with more than 90% of the European population showing detectable concentrations in urine. , In addition, newer phthalates such as bis(2-propylheptyl) phthalate (DPHP) and the nonphthalate substitute 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) have recently entered the market, showing increasing concentrations in humans over time. , Since these new chemicals have a similar structure to those they replace and could potentially exert deleterious effects, , there is a need for continuous biomonitoring and surveillance. , …”

Section: Introductionmentioning

confidence: 99%

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Longitudinal Associations between Prenatal Exposure to Phthalates and Steroid Hormones in Maternal Hair Samples from the SEPAGES Cohort

Mustieles,

Lascouts,

Pozo

et al. 2023

Environ. Sci. Technol.

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We assessed phthalate-hormone associations in 382 pregnant women of the new-generation SEPAGES cohort (2014–2017, France) using improved exposure and outcome assessments. Metabolites from seven phthalate compounds and the replacement di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) were measured in within-subject pools of repeated urine samples collected at the second and third pregnancy trimesters (≈21 samples/trimester). Metabolites from five steroid hormones were measured in maternal hair samples collected at delivery, reflecting cumulative levels over the previous weeks to months. Adjusted linear regression and Bayesian weighted quantile sum (BWQS) mixture models were performed. Each doubling in third-trimester urinary mono-benzyl phthalate (MBzP) concentrations was associated with an average increase of 13.3% (95% CI: 2.65, 24.9) for ∑cortisol, 10.0% (95% CI: 0.26, 20.7) for ∑cortisone, 17.3% (95% CI: 1.67, 35.4) for 11-dehydrocorticosterone, and 16.2% (95% CI: 2.20, 32.1) for testosterone, together with a suggestive 10.5% (95% CI: −1.57, 24.1) increase in progesterone levels. Each doubling in second-trimester urinary di-isononyl phthalate (DiNP) concentrations was inversely associated with testosterone levels (−11.6%; 95% CI: −21.6, −0.31). For most hormones, a nonsignificant trend toward a positive phthalate mixture effect was observed in the third but not in the second trimester. Our study showed that exposure to some phthalate metabolites, especially MBzP, may affect adrenal and reproductive hormone levels during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Longitudinal Associations between Prenatal Exposure to Phthalates and Steroid Hormones in Maternal Hair Samples from the SEPAGES Cohort

Mustieles,

Lascouts,

Pozo

et al. 2023

Environ. Sci. Technol.

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Human biomonitoring of environmental contaminants in Gulf Countries – current status and future directions

Khaled,

Elabed,

Masarani

et al. 2023

Environmental Research

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Toxicokinetic model of the pyrethroid pesticide lambda-cyhalothrin, main exposure route and dose reconstruction predictions in agricultural workers

Côté,

Bouchard

2024

PLoS ONE

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A toxicokinetic model of the pyrethroid insecticide lambda-cyhalothrin (LCT) was developed to relate absorbed doses to urinary cis-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid (CFMP) metabolite levels used as a biomarker of exposure. The model then served to reconstruct absorbed doses in agricultural workers and their probability of exceeding the EFSA Acceptable occupational Exposure Level (AOEL). The toxicokinetic model was able to reproduce the temporal profiles of CFMP in the urine of operators spraying pesticides using the optimized model parameters (adjusted to human volunteer data). Modeling also showed that simulation of an inadvertent oral exposure mainly was the exposure scenario giving the best fit to CFMP urinary time-course data in applicators. With the dermal model parameters optimized from data in volunteers, simulation of a dermal exposure in applicators did not allow to reproduce the observed peak excretions and urinary metabolite levels; extremely high applied dermal doses would be required but still simulated dermal penetration rate would remain too slow. Simulation of an inhalation exposure allowed to reproduce the observed time-courses, but with unrealistic air concentrations. For applicators with the highest urinary concentrations, there was a probability of exceeding the AOEL at some points during the biomonitoring period [>50% probability of exceeding for 27% of 24-h samples]; for non-applicator workers the probability of exceeding the AOEL value was very low [corresponding value of 5%]. Furthermore, the median [95% CI] estimates of 10 000 Monte Carlo simulations led to a biological reference value corresponding to the AOEL of 116 [113–119] ng/kg bw/d and 7.5 [7.3–7.7] μg/L. Overall, 7% of applicators and 1% of workers performing weeding and strawberry picking had a probability of exceeding this biological reference value. As a next step, it would be interesting to apply these methods to multiple exposure to various contaminants.

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Human-Biomonitoring für Europa (HBM4EU) – erste Einblicke in die Ergebnisse der Initiative

Cited by 3 publications

References 14 publications

Longitudinal Associations between Prenatal Exposure to Phthalates and Steroid Hormones in Maternal Hair Samples from the SEPAGES Cohort

Longitudinal Associations between Prenatal Exposure to Phthalates and Steroid Hormones in Maternal Hair Samples from the SEPAGES Cohort

Human biomonitoring of environmental contaminants in Gulf Countries – current status and future directions

Toxicokinetic model of the pyrethroid pesticide lambda-cyhalothrin, main exposure route and dose reconstruction predictions in agricultural workers

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