Human bocavirus in Italian patients with respiratory diseases

Maggi, Fabrizio; Andreoli, Elisabetta; Pifferi, Massimo; Meschi, Silvia; Rocchi, J; Bendinelli, Mauro

doi:10.1016/j.jcv.2007.01.008

Cited by 125 publications

(152 citation statements)

References 24 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…Rates of detection tend to be higher in children <1 year of age (4,10). The incidence of HBoV infections also tends to be higher in samples from the lower respiratory tract, such as NPA or BAL (4.4%-19%) (2,7,9,11,13,19,21,22), than in nasal swabs (1%-6%) (10,15,16,18). The percentage of co-pathogens in our HBoV-positive children (71%) was comparable with those reported in the literature, with rates of co-infections ranging from 35% to 90% (2,3,7,(9)(10)(11)(20)(21)(22).…”

Section: Discussionsupporting

confidence: 83%

“…Fry et al (10) detected HBoV DNA in only 1% of nasal swabs from asymptomatic patients. Maggi et al (16) did not detect HBoV DNA in nasal swabs from 51 asymptomatic children (including 30 healthy infants with a mean age of 6 months and 21 preadolescent healthy children with a mean age of 12.8 years). However, these studies analyzed nasal swabs instead of NPA or BAL samples for HBoV detection, which may result in lower rates of viral detection, as shown in symptomatic persons.…”

Section: Discussionmentioning

confidence: 98%

“…Bastien et al (5) reported an overall rate of infection of 1.5% in respiratory samples negative for other viruses, with no differences between age groups. Maggi et al (16) reported only 1 HBoV-positive sample from an adult with lymphoma in 62 bronchoalveolar lavages (BALs). These investigators also tested 22 nasal swabs from adults with persistent asthma symptoms and found no samples positive for HBoV.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Human Bocavirus Infections in Hospitalized Children and Adults

Longtin

Bastien

Gilca

et al. 2008

Emerg. Infect. Dis.

144

120

View full text Add to dashboard Cite

Studies have reported human bocavirus (HBoV) in children with respiratory tract infections (RTIs), but only occasionally in adults. We searched for HBoV DNA in nasopharyngeal aspirates (NPAs) from adults with exacerbations of chronic bronchitis or pneumonia, from children hospitalized for acute RTIs, and from asymptomatic children during the winter of 2002-2003 in Canada. HBoV was detected in NPAs of 1 (0.8%) of 126 symptomatic adults, 31 (13.8%) of 225 symptomatic children, and 43 (43%) of 100 asymptomatic children undergoing elective surgery. Another virus was detected in 22 (71%) of the 31 HBoV-positive NPAs from symptomatic children. Two clades of HBoV were identifi ed. The pathogenic role of HBoV in RTIs is uncertain because it was frequently detected in symptomatic and asymptomatic children and was commonly found with other viruses in symptomatic children.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Human Bocavirus Infections in Hospitalized Children and Adults

Longtin

Bastien

Gilca

et al. 2008

Emerg. Infect. Dis.

144

120

View full text Add to dashboard Cite

show abstract

“…Previous studies found no HBoV infection among symptomatic adults 1 , and others reported frequencies of less than 1% among those and/or the elderly 14,15 . Although GUIDO et al (2011) described an HBoV frequency of 18.9% among immunocompetent adults 10 .…”

Section: Discussionmentioning

confidence: 85%

Frequency of human bocavirus respiratory infections among at-risk patients in São Paulo, Brazil

Caccia

Watanabe

Carraro³

et al. 2012

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYBackground and objectives: Human Bocavirus (HBoV) has been described since 2005 as an etiological agent of respiratory virus infections. From 2001 to 2008 we investigated the etiology of HBoV among adults and children in different groups at risk of presenting complications arising from acute respiratory infection, the investigation was carried out in a tertiary hospital health care system in Brazil. Methods: HBoV DNA was assayed in 598 respiratory samples from community and hospitalized patients by PCR.Results: Of the 598 tested samples, 2.44% (8/328) of children, including five children with heart disease, and 0.4% (1/270) of adult bone-marrow-transplant were HBoV positive. Conclusions: These data suggested lower HBoV frequency among different at-risk patients and highlights the need to better understand the real role of HBoV among acute respiratory symptomatic patients.

show abstract

“…It was subsequently detected in serum (16)(17), fecal (18)(19) and urine samples (20). HBoV detection was significantly higher in patients with symptoms of respiratory tract infections or gastroenteritis than in asymptomatic individuals (14,16,(21)(22)(23). Findings of a recent study suggest that acute infection of HBoV causes systemic infection, induces immune responses and is often associated with coinfection (24).…”

Section: Introductionmentioning

confidence: 99%

High prevelance of human parvovirus infection in patients with malignant tumors

Dong

Jiang

et al. 2012

Oncology Letters

View full text Add to dashboard Cite

Abstract.It is well known that the immunity of patients with malignant tumors decreases significantly. An increased parvovirus B19 (B19) infection rate has been observed in immunocompromised hosts. However, only a small amount of literature regarding the risk of human parvovirus infection in patients with malignant tumors is available. To evaluate the correlation of human parvovirus infection with malignant tumors, 288 serum samples from patients with malignant tumors were screened for B19 DNA by nested-PCR. The serum samples, 156 of which were from known clinicopathological cancer patients, were subjected to analysis of the seropositive rate of human bocavirus (HBoV), hepatitis B virus (HBV) and transfusion transmitted virus (TTV) by PCR. A total of 800 normal population sera and 941 aspirate samples from children with respiratory tract infections were used as controls for the detection of B19 and HBoV, respectively. Pairwise comparison between cancerous serum and control samples, and the correlation between parvovirus infection and clinicopathological variables, including gender and cancer type, were evaluated using the χ2 test, Fisher's exact test or the t-test. P<0.05 was considered to indicate a statistically significant difference. The overall prevalence of B19 DNA in cancer patients was 50.69% (146/288), which was significantly higher than that of the healthy controls with 4.5% (36/800) (χ2 test, P<0.0001). Similar results were obtained for HBoV with a 39.74% (62/156) prevalence in cancer patients. However, the infection prevalence of HBV and TTV in the cancer patients was 5.13 (8/156) and 6.41% (10/156), respectively (P<0.0001), which was much less than that of B19 and HBoV. These results revealed that a high risk of B19 and HBoV infection occurred in cancer patients, and a potential correlation exists between parvovirus infection and occurrence of malignant tumors.

show abstract

Human bocavirus in Italian patients with respiratory diseases

Cited by 125 publications

References 24 publications

Human Bocavirus Infections in Hospitalized Children and Adults

Human Bocavirus Infections in Hospitalized Children and Adults

Frequency of human bocavirus respiratory infections among at-risk patients in São Paulo, Brazil

High prevelance of human parvovirus infection in patients with malignant tumors

Contact Info

Product

Resources

About