Human bocaviruses and paediatric infections

Christensen, Andreas; Kesti, Olli; Elenius, Varpu; Eskola, Anna; Døllner, Henrik; Altunbulakli, Can; Akdiş, Cezmi A.; Söderlund‐Venermo, Maria; Jartti, Tuomas

doi:10.1016/s2352-4642(19)30057-4

Cited by 71 publications

(161 citation statements)

References 97 publications

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“…The widely used qualitative HBoV1 DNA PCRs yield results of low clinical specificity and very low PPV [1,2,6,7,14]. We confirmed this.…”

Section: Discussionsupporting

confidence: 82%

“…Serological tests based on detection of HBoV1-specific IgM and increases of IgG in paired serum samples are well-established reference methods in clinical studies [1,2,6,14]. However, sera were not obtained from the children included in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Among adults with RTI, HBoV1 DNA is rarely detected. Sample sizes in studies on adults have been too small to conclude the clinical significance of HBoV1-DNA positivity [1,2].…”

Section: Discussionmentioning

confidence: 99%

“…Human bocavirus 1 (HBoV1) is a common cause of respiratory tract infections (RTI) in young children and causes serious lower RTI in children younger than six years of age [1][2][3][4][5]. The diagnosis of HBoV1 infections has traditionally been based on qualitative PCRs detecting viral DNA.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of phenotypic and genotypic diagnosis of acute human bocavirus 1 infection in children

Kols

Aatola²,

Peltola

et al. 2019

Journal of Clinical Virology

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“…The widely used qualitative HBoV1 DNA PCRs yield results of low clinical specificity and very low PPV [1,2,6,7,14]. We confirmed this.…”

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

“…Among adults with RTI, HBoV1 DNA is rarely detected. Sample sizes in studies on adults have been too small to conclude the clinical significance of HBoV1-DNA positivity [1,2].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of phenotypic and genotypic diagnosis of acute human bocavirus 1 infection in children

Kols

Aatola²,

Peltola

et al. 2019

Journal of Clinical Virology

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“…Our hospital did not detect HBoV from BAL fluid in any of 50 asymptomatic adults (unpublished data), indicating the rarity of HBoV detection in BAL fluid from asymptomatic adults. Another study showed that HBoV DNA is rarely detected in respiratory samples of adult patients over 65 years of age with or without a respiratory tract infection (6). Other studies have shown HBoV DNA to be common in tonsillar tissue taken from children with hypertrophic tonsils (8).…”

mentioning

confidence: 99%

Fatal Primary Human Bocavirus Pneumonia in an Immunocompetent Adult

Ishiguro¹,

Hirota²,

Kobayashi

et al. 2020

Intern. Med.

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A 70-year-old woman was admitted to our hospital for dyspnea and a fever of 2 weeks duration. Chest imaging showed bilateral infiltration, and a rapid diagnostic test for influenza virus, Mycoplasma pneumoniae, Streptococcus pneumoniae, and Legionella spp. was negative. She was intubated and mechanically ventilated and underwent bronchoalveolar lavage. Bronchoalveolar lavage fluid yielded no significant pathogens, and the multiplex polymerase chain reaction test was positive only for human bocavirus. Specific antibodies against significant pathogens were not increased in paired sera, so we diagnosed her with primary human bocavirus pneumonia.

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Parvovirus B19V, Bocaviruses, and Other Human Parvoviruses

Söderlund‐Venermo

2023

ClinMicroNow

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Parvoviruses are small, nonenveloped icosahedral viruses with a linear single‐stranded‐DNA (ssDNA) genome in the family Parvoviridae in the realm Monodnaviria . The family Parvoviridae is divided into three subfamilies, Parvovirinae , Densovirinae , and the new Hamaparvovirinae , on the basis of their ability to infect vertebrates, invertebrates, or both, respectively, and their NS1 amino acid sequences. The first human parvoviruses identified were the nonpathogenic adeno‐associated viruses of the genus Dependoparvovirus , which are increasingly used in gene therapy. Human bocavirus (HBoV1) has the typical structure of a member of the Parvoviridae . The most common test for diagnosis of HBoV1 infection is DNA detection by qualitative PCR. Parvoviruses are unable to induce cells to divide, so they require actively dividing cells for their replication.

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Human bocaviruses and paediatric infections

Cited by 71 publications

References 97 publications

Comparison of phenotypic and genotypic diagnosis of acute human bocavirus 1 infection in children

Comparison of phenotypic and genotypic diagnosis of acute human bocavirus 1 infection in children

Fatal Primary Human Bocavirus Pneumonia in an Immunocompetent Adult

Parvovirus B19V, Bocaviruses, and Other Human Parvoviruses

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