Human Breast Milk: Current Concepts of Immunology and Infectious Diseases

Lawrence, Robert M.; Pane, C

doi:10.1016/j.cppeds.2006.10.002

Cited by 155 publications

(150 citation statements)

References 173 publications

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…Epidermal growth factor helps to induce maturation of the intestinal epithelium, immunoglobulin A and oligosaccharides prevent attachment of pathogens, and lactoferrin has broad antimicrobial properties including disruption of the bacterial outer membrane. 39,40 The strength of this study is its prospective population-based cohort design with a large number of subjects and the possibility to adjust for all major confounders. In addition, we were able to categorize the various breastfeeding habits in combination with the duration of breastfeeding.…”

Section: Discussionmentioning

confidence: 99%

Prolonged and Exclusive Breastfeeding Reduces the Risk of Infectious Diseases in Infancy

Duijts¹,

et al. 2010

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT:Exclusive breastfeeding seems to decrease the risk of infectious diseases in infancy. However, the World Health Organization has called for more research regarding the benefits for 6 months instead of 4 months of exclusive breastfeeding. WHAT THIS STUDY ADDS:Exclusive breastfeeding to the age of 6 months tended to be more protective than exclusive breastfeeding until the age of 4 months and partially thereafter. Our findings support health-policy strategies that promote exclusive breastfeeding for 6 months in industrialized countries. abstract OBJECTIVE: To examine the associations of duration of exclusive breastfeeding with infections in the upper respiratory (URTI), lower respiratory (LRTI), and gastrointestinal tracts (GI) in infancy. METHODS:This study was embedded in the Generation R Study, a population-based prospective cohort study from fetal life onward in the Netherlands. Rates of breastfeeding during the first 6 months (never; partial for Ͻ4 months, not thereafter; partial for 4 -6 months; exclusive for 4 months, not thereafter; exclusive for 4 months, partial thereafter; and exclusive for 6 months) and doctor-attended infections in the URTI, LRTI, and GI until the age of 12 months were assessed by questionnaires and available for 4164 subjects. RESULTS:Compared with never-breastfed infants, those who were breastfed exclusively until the age of 4 months and partially thereafter had lower risks of infections in the URTI, LRTI, and GI until the age of 6 months (adjusted odds ratio . Similar tendencies were observed for infants who were exclusively breastfed for 6 months or longer. Partial breastfeeding, even for 6 months, did not result in significantly lower risks of these infections. CONCLUSIONS:Exclusive breastfeeding until the age of 4 months and partially thereafter was associated with a significant reduction of respiratory and gastrointestinal morbidity in infants. Our findings support healthpolicy strategies to promote exclusive breastfeeding for at least 4 months, but preferably 6 months, in industrialized countries.

show abstract

Section: Discussionmentioning

confidence: 99%

Prolonged and Exclusive Breastfeeding Reduces the Risk of Infectious Diseases in Infancy

Duijts¹,

et al. 2010

View full text Add to dashboard Cite

show abstract

“…La presencia de estos factores protectores se traduce en una serie de ventajas digestivas (maduración de la mucosa intestinal a través de los factores de crecimiento y hormonas que aporta, dificultando que los agentes patógenos puedan penetrar la pared intestinal) y defensivas (11). La IgA tiene un papel predominante dentro de estos factores bioactivos de la leche materna, ya que se une directamente a antígenos microbianos específicos, bloqueando su adhesión, favoreciendo la fagocitosis y modulando la función inmune a nivel local (12,13).…”

Section: Introductionunclassified

Efectos de la administración de calostro orofaríngeo en recién nacidos prematuros sobre los niveles de inmunoglobulina A

Álvarez¹,

Cabanillas²,

Peña‐Caballero³

et al. 2016

Nutr Hosp

View full text Add to dashboard Cite

Introducción: el recién nacido prematuro de muy bajo peso (RNMBP) es inmunológicamente inmaduro y además presenta una alteración de las barreras naturales de defensa. Objetivo: evaluar los efectos que pueda tener la administración de calostro orofaríngeo, administrado durante los primeros 15 días posnatales, sobre los niveles de inmunoglobulina A (IgA) sérica en recién nacidos prematuros de muy bajo peso durante el primer mes de vida. Material y métodos: se desarrolló un estudio de intervención no aleatorizado con grupo control, en el que se incluyeron 38 recién nacidos con ≤ 32 + 6 semanas de gestación y/o menores de 1.500 g de peso. Los sujetos recibieron 0,2 ml de calostro de su madre cada 4 h, iniciándose el procedimiento en las primeras 24 h de vida hasta el 15.o día postnatal. Se midieron los niveles de IgA en la sangre al nacimiento, 3. er , 15.o y 30.o días de vida. Se registraron datos perinatales al nacimiento y durante el periodo de seguimiento. Resultados: IgA sérica aumentó de forma estadísticamente significativa en el grupo de intervención (M1 15,84 μg/ml, M2 20,07 μg/ml, M3 23,65 μg/ml, M4 30,34 μg/ml, p 0,001) y en el grupo control (M1 12,48 μg/ml, M2 16,48 μg/ml, p 0,018; M3 19,41 μg/ml, M4 22,48 μg/ml, p 0,001). Al mes de vida, los niveles de IgA sérica fueron significativamente mayores en el grupo de intervención que en el grupo control (p 0,026). Conclusiones: este estudio sugiere que la administración de calostro orofarínge

show abstract

“…Newborns lack the ability to launch effective immune responses against microorganisms, and for several months after birth, the primary defense against infections is the passive immunity provided by maternal antibodies. Colostrum and human milk have been thoroughly studied in recent years, ever since their protective role against infections was confirmed (Honorio- França et al, 1997, Honorio-França et al, 2001, França-Botelho et al, 2006, Lawrence & Pane, 2007, França et al, 2011a, França et al, 2011b. Human milk was first used clinically as a vehicle for the transfer of passive immunity, but its immune components are now known to be highly immunoreactive, exhibiting timedependent alterations.…”

Section: Immunological and Environmental Factors In Human Milkmentioning

confidence: 99%