Human cartilage gp‐39+,CD16+ monocytes in peripheral blood and synovium: Correlation with joint destruction in rheumatoid arthritis

Baeten, Dominique; Boots, Annemieke M. H.; Steenbakkers, Peter G. A.; Elewaut, Dirk; Bos, Ebo; Verheijden, Gfm; Verbruggen, Gust; Miltenburg, A. M. M.; Rijnders, A.W.M.; Veys, Eric; Keyser, Filip De

doi:10.1002/1529-0131(200006)43:6<1233::aid-anr6>3.0.co;2-9

Cited by 152 publications

(133 citation statements)

References 26 publications

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“…Previously we demonstrated that HC gp-39 is not expressed exclusively in articular cartilage but is found also in inflamed synovium and that the synovial membrane is a privileged site for presentation of this protein to the immune system (6,14,19). In immunohistochemistry analyses for MIA in the present study, collected biopsies described previously (14,19,29,33) were used to investigate local expression of MIA in the synovium, with mAb 14A.…”

Section: Resultsmentioning

confidence: 68%

“…Additional SF samples from RA, SpA, and osteoarthritis (OA) patients originated from a previous study (28). Synovial membrane biopsy specimens from another group of patients (described in previous reports [14,19,29]) were obtained for immunohistochemistry studies. Eight biopsy samples per patient (17 RA, 13 SpA, 6 OA), obtained from an inflamed knee joint by needle arthroscopy (30), were studied.…”

Section: Methodsmentioning

confidence: 99%

“…For immunohistochemistry, the ST sections were blocked with 10% normal human serum and incubated overnight with mAb 14A (1 g/ml). Staining was performed as described previously (14,19,29,33), using an LSABϩ kit according to the instructions of the manufacturer (DakoCytomation, Glostrup, Denmark). Parallel sections were incubated with concentration-and isotype-matched irrelevant antibody (Dako Cytomation) as a negative control.…”

Section: Methodsmentioning

confidence: 99%

“…Specimens derived from a lymph node containing metastasized melanoma and specimens of healthy articular cartilage were used as positive controls. For comparison, ST samples were also stained for HC gp-39 as described previously (14).…”

Section: Methodsmentioning

confidence: 99%

“…Although the physiologic function of HC gp-39 is still unknown, its expression is specifically induced under pathologic conditions such as RA (8,(11)(12)(13). In RA patients, HC gp-39 is expressed not only by chondrocytes, but also by mature CD16-positive macrophages in the synovium (14) and by peripheral blood-derived macrophages during their differentiation from monocytes (15)(16)(17)(18).…”

mentioning

confidence: 99%

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Endogenous HLA–DR–restricted presentation of the cartilage antigens human cartilage gp‐39 and melanoma inhibitory activity in the inflamed rheumatoid joint

Lierop¹,

Hoed²,

Houbiers³

et al. 2007

Arthritis & Rheumatism

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Objective. The cartilage proteins melanoma inhibitory activity (MIA) and human cartilage gp-39 (HC gp-39) are candidate autoantigens in rheumatoid arthritis (RA). The present study was undertaken to investigate the endogenous HLA-DR4-restricted presentation of these self proteins, in order to seek in vivo evidence in support of their potential immunologic role. The mechanisms that cause and sustain rheumatoid arthritis (RA) remain poorly elucidated. The association of the disease with certain class II major histocompatibility complex (MHC) haplotypes, however, strongly suggests that specific antigens are presented by antigen-presenting cells (APCs) to CD4ϩ T lymphocytes (1,2). Previous studies indicate that cartilage could be the source of some of these antigens in RA (3-7). In the present study we investigated the local presence and presentation of 2 cartilage-derived proteins that have distinct properties: human cartilage gp-39 (HC gp-39) and a protein called melanoma inhibitory activity (MIA).

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Section: Resultsmentioning

confidence: 68%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Endogenous HLA–DR–restricted presentation of the cartilage antigens human cartilage gp‐39 and melanoma inhibitory activity in the inflamed rheumatoid joint

Lierop¹,

Hoed²,

Houbiers³

et al. 2007

Arthritis & Rheumatism

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Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations

Yamada

Hattori

Iwayama

et al. 2008

American J of Med Genetics Pt B

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Recently, three common polymorphisms in the promoter region of the Chitinase 3-Like 1 (CHI3L1) gene, rs6691378, rs10399805 and rs4950928, have been identified as schizophrenia predisposing single nucleotide polymorphisms (SNPs) in the Han Chinese population. The at-risk haplotype comprising these SNPs was also related to decreased expression of CHI3L1 in peripheral blood cells. In contrast, two independent postmortem brain studies have reported elevated expression of the transcript in the hippocampus and prefrontal cortex, from schizophrenic patients. The gene encodes a secreted glycoprotein (HC-gp39 or YKL40), which is deemed to be involved in the inflammatory process. These pieces of evidence signify the potential importance of CHI3L1 in the pathogenesis of schizophrenia. In this study, we aimed to replicate the prior genetic association findings using two sample sets, one set of Chinese samples (293 pedigrees consisting of 1,163 subjects) that are ethnically identical to those used in the original report and a second set from the relatively close Japanese population (570 schizophrenic patients and 570 matched controls). We analyzed the same five SNPs as in the original study, including the three promoter SNPs. None of these SNPs showed association signals with schizophrenia (P values >0.108) in our sample sets. These results suggest that the genetic contribution of CHI3L1 to schizophrenia is variable, even though it is mechanistically involved in the disease process.

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Rheological properties of ionically and covalently crosslinked polypropylene‐type thermoplastic elastomers

Fujiyama

Kondou

Ayama

et al. 2002

J of Applied Polymer Sci

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Maleic anhydride was grafted onto a polypropylene-type thermoplastic elastomer PER by reactive processing with a screw extruder, and a maleated PER (MPER) was prepared. Aiming at ionic crosslinking, magnesium 12-hydroxy stearate (MgStOH), zinc oxide (ZnO), and zinc sulfide (ZnS), and aiming at covalent crosslinking, melamine as an amino compound, and Epocizer and GRYCI-ALE as epoxy compounds, were added to the MPER, melt-mixed by use of the screw extruder, and crosslinked compounds were obtained. The rheological properties such as capillary flow properties and dynamic viscoelasticities of the compounds were measured and their melt processabilities were evaluated. The degree of crosslinking was in the order of epoxy compounds Ͼ MgStOH Ͼ melamine Ͼ ZnO, ZnS Ͼ MPER (blank). In the case of the compound with MgStOH of a moderately high degree of crosslinking, the nonNewtonian behavior is remarkable and the die swell ratio is low and suitable for extrusion. However, in the case of compounds with epoxy compounds of an excessive degree of crosslinking, fine extrudate cannot be obtained due to the lack of fusion and the control of degree of crosslinking is necessary.

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Human cartilage gp‐39+,CD16+ monocytes in peripheral blood and synovium: Correlation with joint destruction in rheumatoid arthritis

Cited by 152 publications

References 26 publications

Endogenous HLA–DR–restricted presentation of the cartilage antigens human cartilage gp‐39 and melanoma inhibitory activity in the inflamed rheumatoid joint

Endogenous HLA–DR–restricted presentation of the cartilage antigens human cartilage gp‐39 and melanoma inhibitory activity in the inflamed rheumatoid joint

Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations

Rheological properties of ionically and covalently crosslinked polypropylene‐type thermoplastic elastomers

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