Human Case of<i>Streptococcus suis</i>Disease, Ontario, Canada

Gomez-Torres, Jeisa; Nimir, Asim; Cluett, James; Aggarwal, Anita; Elsayed, Sameer; Soares, Deirdre; Teatero, Sarah; Chen, Yan; Gottschalk, Marcelo; Fittipaldi, Nahuel

doi:10.3201/eid2312.171005

Cited by 22 publications

(19 citation statements)

References 9 publications

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“…Misidentification of S. suis is very common: this bacterium is frequently misidentified as Streptococci viridans [14] and has also been misidentified as Streptococcus bovis, Streptococcus pneumoniae, Streptococcus faecalis, and Streptococcus acidominimus [2,6,21,83]. Misidentification of S. suis also has been reported in Canada, which raises suspicion that human S. suis infections might be underdiagnosed in North America [84,85]. In the report by Tarini et al, a previously healthy 50-year-old man was admitted to one of the district hospitals in Bali Province, Indonesia, due to meningitis.…”

Section: Discussion and Review Of European Literaturementioning

confidence: 99%

Fatal case of bacteremia caused by Streptococcus suis in a splenectomized man and a review of the European literature

Ágoston

Terhes

Hannauer

et al. 2020

AMicr

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Streptococcus suis is an emerging zoonotic human pathogen, which is a causative agent of invasive infections in people who are in close contact with infected pigs or contaminated pork products. It is associated with severe systemic infections, most commonly meningitis and sepsis, which may lead to high rates of morbidity and mortality. Serotype 2 is the most prevalent type in S. suis infections in humans. We have reported a case of a very rapidly proceeding fatal human S. suis infection in a splenectomized, but otherwise immunocompetent patient in Hungary. We would like to highlight the attention for this pathogen for the risk group patients, not only pig breeders, veterinarians, abattoir workers, meat processing and transport workers, butchers and cooks, that those persons who are immunocompromised including those with spleen removed, persons with diabetes mellitus, cancer and alcoholism, are also at greater risk of infection.

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Section: Discussion and Review Of European Literaturementioning

confidence: 99%

Fatal case of bacteremia caused by Streptococcus suis in a splenectomized man and a review of the European literature

Ágoston

Terhes

Hannauer

et al. 2020

AMicr

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“…High-throughput sequencing systems are now available at many public health and hospital diagnostic laboratories, and the use of these systems in rapid diagnosis of S. suis has shown great potential. A report from Canada described that WGS (Illumina MiSeq) was instrumental in identifying S. suis serotype 2 ST25 as the causative agent of a human infection in a farmer, which had previously been ascribed to the viridans group Streptococcus by biochemical methods [55]. More recently, Hayashi et al (2019) used Illumina short-reads to investigate two human S. suis cases in Japan.…”

Section: Whole-genome Sequencing Approachesmentioning

confidence: 99%

Tools for Molecular Epidemiology of Streptococcus suis

et al. 2020

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Diseases caused by Streptococcus suis are a significant economic and welfare concern in pigs as well as in humans. Several molecular methods have been applied to investigate S. suis strain diversity and identify phylogenetic groups. Multilocus sequence typing (MLST), commonly used to differentiate between S. suis strains, has been instrumental in identifying that the species is genetically highly diverse. Recent advances in whole-genome analysis have resulted in schemes permitting the classification of S. suis populations as pathogenic or non-pathogenic, or disease-associated or non-disease associated. Here, we review these and other molecular approaches that can be used for surveillance, outbreak tracking, preventative health management, effective treatment and control, as well as vaccine development, including PCR based-assays that are easy to apply in modest diagnostic settings and which allow for the rapid screening of a large number of isolates at relatively low cost, granting the identification of several major clonal complexes of the S. suis population.

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“…It is also a major agent of human meningitis in Asia [2]. In Western countries, cases are less frequent but can be severe and even fatal [3][4][5]. The most prevalent serotype causing human infection is serotype 2, although virulence differs among MultiLocus-Sequence-Typing (MLST) groups [2,5].…”

Section: Introductionmentioning

confidence: 99%

Chromosomal Conjugative and Mobilizable Elements in Streptococcus suis: Major Actors in the Spreading of Antimicrobial Resistance and Bacteriocin Synthesis Genes

et al. 2019

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Streptococcus suis is a zoonotic pathogen suspected to be a reservoir of antimicrobial resistance (AMR) genes. The genomes of 214 strains of 27 serotypes were screened for AMR genes and chromosomal Mobile Genetic Elements (MGEs), in particular Integrative Conjugative Elements (ICEs) and Integrative Mobilizable Elements (IMEs). The functionality of two ICEs that host IMEs carrying AMR genes was investigated by excision tests and conjugation experiments. In silico search revealed 416 ICE-related and 457 IME-related elements. These MGEs exhibit an impressive diversity and plasticity with tandem accretions, integration of ICEs or IMEs inside ICEs and recombination between the elements. All of the detected 393 AMR genes are carried by MGEs. As previously described, ICEs are major vehicles of AMR genes in S. suis. Tn5252-related ICEs also appear to carry bacteriocin clusters. Furthermore, whereas the association of IME-AMR genes has never been described in S. suis, we found that most AMR genes are actually carried by IMEs. The autonomous transfer of an ICE to another bacterial species (Streptococcus thermophilus)—leading to the cis-mobilization of an IME carrying tet(O)—was obtained. These results show that besides ICEs, IMEs likely play a major role in the dissemination of AMR genes in S. suis.

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Human Case ofStreptococcus suisDisease, Ontario, Canada

Cited by 22 publications

References 9 publications

Fatal case of bacteremia caused by Streptococcus suis in a splenectomized man and a review of the European literature

Fatal case of bacteremia caused by Streptococcus suis in a splenectomized man and a review of the European literature

Tools for Molecular Epidemiology of Streptococcus suis

Chromosomal Conjugative and Mobilizable Elements in Streptococcus suis: Major Actors in the Spreading of Antimicrobial Resistance and Bacteriocin Synthesis Genes

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