Human choriogonadotropin

Puett, David

doi:10.1002/bies.950040207

Cited by 8 publications

(3 citation statements)

References 33 publications

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“…Here the type 1 IgA1 protease of N. gonorrhoeae cleaves a specific P-S peptide bond, whereas the type 2 IgA1 protease cleaves a specific P-T peptide bond [11]. There is no P-T site in the b-CTP region of hCG [4], which may account for the resistance of bhCG to cleavage by the type 2 gonococcal IgA1 proteases seen by autoradiography and immunoblotting. However, there are 4 P-S sites in b-hCG, and all are clustered toward the carboxy terminus of the CTP [4].…”

Section: Discussionmentioning

confidence: 91%

“…There is no P-T site in the b-CTP region of hCG [4], which may account for the resistance of bhCG to cleavage by the type 2 gonococcal IgA1 proteases seen by autoradiography and immunoblotting. However, there are 4 P-S sites in b-hCG, and all are clustered toward the carboxy terminus of the CTP [4]. Cleavage of b-hCG by gonococcal type 1 IgA1 protease at у1 of these peptide bonds would create a small fragment (∼1 kDa) lacking tyrosine.…”

Section: Discussionmentioning

confidence: 96%

“…hCG may also prevent Neisseria gonorrhoeae from invading fallopian tube membranes by inhibiting binding by the organism's surface-located ribosomal protein L12 to the luteinizing hormone receptor (LHR), a step that likely allows the organism to eventually invade the cell [2,3]. This happens because the hCG structure is very similar to that of luteinizing hormone (LH) [4]. Both contain a and b subunits that combine noncovalently to form the intact hormone in the form of ab dimers.…”

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confidence: 99%

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Cleavage of the Hormone Human Chorionic Gonadotropin, by the Type 1 IgA1 Protease ofNeisseria gonorrhoeae,and Its Implications

et al. 2001

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The hormone human chorionic gonadotropin (hCG) serves to maintain the fetus during early pregnancy and regulate the onset of labor in late pregnancy. hCG also prevents Neisseria gonorrhoeae from developing invasive characteristics. Part of the beta subunit of hCG has an amino acid sequence similar to that of the hinge of human IgA1, which is the site of action of IgA1 proteases. This study examined the sensitivity of hCG to gonococcal IgA1 proteases, by means of autoradiography, immunoblotting, and RIA. hCG was cleaved in the beta subunit by the type 1 but not the type 2 IgA1 proteases of N. gonorrhoeae. hCG cleavage by gonococcal IgA1 proteases in vivo may increase the invasiveness of the pathogen and destroy its natural biologic activity, with major consequences for the fetus and the pregnancy.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

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Cleavage of the Hormone Human Chorionic Gonadotropin, by the Type 1 IgA1 Protease ofNeisseria gonorrhoeae,and Its Implications

et al. 2001

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Human Recombinant Follicle Stimulating Hormone (Follitropin‐α)

Peinado¹,

Howles²,

Tresguerres³

2000

Novel Therapeutic Proteins

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Pharmaproteine

Blohm¹,

Bollschweiler²,

Hillen³

1988

Angew. Chem.

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Professor Helmut Dorfel ?urn 60. Gehurtstug gewidmetIler Begriff Pharmaproteine steht fur ein hochaktuelles Arbeitsgebiet, das sich von der Grundlagenforschung bis hin zum pharmazeutischen Markt in r ntem Wachstum befintict. Ausgangspunkt dieser Entwicklung sind Gen-und Biotechnologie, die zur Entdeckung n w e r Proteine beitragen und es ermoglichen, sie irn praparativen MaRstab herzustellen. Scit der Markteinfuhrung des lnsulins (l923), des Thyroidhormons (1934). des Faktors VIII ( 1948) und des Calcitonins (1970) sind Hormone, Serumproteine und Enzyme als Therapeutica fest etabliert. lmmunmodulatoren und Gewebsproteine sind als neuer Ansatz in der Tumortherapie in einer sturmischen Entwicklungsphase. Diagnostica werden mehr und inehr auf Enzyme und rnonoklonale Antikorper umgestellt, und seit kurzem werden auch V:iccine auf Basis definierter Einzelproteine und Oligopeptide entwickelt. Von den uber 200 tittrzeit bearbeiteten Pharmaproteinen befinden sich mehr als die H d f t e im Forschungswid Entwicklungsstadiurn. an die 100 in der klinischen Prufung, und gut ein I h t z e n d hat bcreits den Markt erreicht. lhre wichtigsten lndikationsgebiete sind Herz-Kreislauf-, Tumor-und Autoimmunerkrankungen sowie Infektionen. Gen-und biotechnisch hergestellte Proteine konnen als chemisch und biologisch exakt definierte Wirkstoffe nach dem Konzcpt der Therapie mit ,,korpereigenen Proteinwirkstoffen" fur neue Medikamente und in d t r Forschung fur die Erarbeitung neuer therapeutisch nutzbarer Erkenntnisse cingesetzt werden. Die jiingste Entwicklung zeigt. da13 Proteine sowohl in ihrer nativen als auch in modifizierter Form fur die Wirkstofforschung eine immer groRere Bedeutung erlangen.

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Human choriogonadotropin

Cited by 8 publications

References 33 publications

Cleavage of the Hormone Human Chorionic Gonadotropin, by the Type 1 IgA1 Protease ofNeisseria gonorrhoeae,and Its Implications

Cleavage of the Hormone Human Chorionic Gonadotropin, by the Type 1 IgA1 Protease ofNeisseria gonorrhoeae,and Its Implications

Human Recombinant Follicle Stimulating Hormone (Follitropin‐α)

Pharmaproteine

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