Human chorionic gonadotropin administration is associated with high pregnancy rates during ovarian stimulation and timed intercourse or intrauterine insemination

Mitwally, M.F.; Abdel-Razeq, Sonya S.; Casper, Robert F.

doi:10.1186/1477-7827-2-55

Cited by 34 publications

(10 citation statements)

References 37 publications

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“…Notably, ovulation induction with HCG was another factor that was significantly associated with clinical pregnancy after IUI. This is in accordance with previous studies [ 26 , 27 ]. After multivariate analysis, the parameter “male factor” differed only by trend (p = 0.067) between patients who achieved a clinical pregnancy and those who did not.…”

Section: Discussionsupporting

confidence: 94%

The impact of thyroid function on intrauterine insemination outcome - a retrospective analysis

Jatzko

Vytiska-Bistorfer

Pawlik

et al. 2014

Reprod Biol Endocrinol

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BackgroundHashimoto’s thyroiditis is the most common endocrinopathy in premenopausal women, and is associated with various gynecological problems, including recurrent miscarriage and unexplained infertility. A possible influence of Hashimoto’s thyroiditis on the success of intrauterine insemination seems likely, but has not been evaluated as yet. Therefore, the aim of our study was to retrospectively analyze the impact on intrauterine insemination outcome of thyroid function and markers suggestive for Hashimoto’s thyroiditis.MethodsRetrospective cohort study in a tertiary care center of 540 women who underwent Intrauterine Insemination. The clinical pregnancy rate was the main outcome parameters. The following possible influencing factors were tested: thyroid-stimulating hormone (TSH); thyroid autoantibodies; age; body mass index; type of sterility (primary/secondary); parity; male factor; presence of PCO syndrome; ovulation induction; ovarian stimulation; and current thyroid medication.ResultsThe overall clinical pregnancy rate was 6.9% (37/540). Age, thyroid hormone supplementation for thyroid-stimulating hormone (TSH) levels > 2.5 micro-IU/ml, and ovulation induction with HCG were significantly predictive in the multivariate analysis (p < 0.05) as influencing factors for the pregnancy rate after intrauterine insemination.ConclusionsWomen undergoing intrauterine insemination seem to benefit from a strict thyroid hormone supplementation regimen in order to achieve lower TSH levels.

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Section: Discussionsupporting

confidence: 94%

The impact of thyroid function on intrauterine insemination outcome - a retrospective analysis

Jatzko

Vytiska-Bistorfer

Pawlik

et al. 2014

Reprod Biol Endocrinol

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“…They concluded that there seems to be no significant difference between doing IUI from 24 to 48 hours after hCG injection ( 18 ). Some other studies have mentioned the same conclusion ( 12 , 17 , 28 ) .…”

Section: Discussionsupporting

confidence: 62%

“…Natural ovulation usually occurs 37 to 39 hours after the start of luteinizing hormone surge ( 11 ). Follicular rupture and ovulation usually occur 36 to 38 hours after hCG injection ( 12 ). The optimal timing of IUI for improving pregnancy outcome has been mentioned 12, 18, 36-40 hours after hCG injection ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Comparing the Effectiveness of Doing Intra-uterine Insemination 36 and 42 Hours after Human Chorionic Gonadotropin (HCG) Injection on Pregnancy Rate: A Randomized Clinical Trial

Firouz¹,

Noori²,

Ghasemi³

et al. 2020

JFRH

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Objective: Intrauterine insemination (IUI) is an assisted conception technique that involves the deposition of a processed semen sample in the upper uterine cavity, overcoming natural barriers to sperm ascent in the female reproductive tract. Hence, we compared the results of doing intra-uterine insemination 36 and 42 hours after human chorionic gonadotropin (hCG) hormone injection to achieve clinical and chemical pregnancy rates. Materials and methods: One hundred and sixty infertile women with unexplained infertility participated in this clinical trial. They were divided into two groups: those who underwent IUI 36 hours after hCG injection (control group), and those who underwent IUI 42 hours after hCG injection (case group). Statistical analyses were done using IBM-SPSS 25.0. and Chi-square test were used for data analysis. Results: The percentages of clinical and chemical pregnancies were significantly higher in the 42h group compared to the other group (P = 0.038 vs. P = 0.009, respectively). There was no significant difference regarding frequency of abortion, twin and ectopic pregnancies between the two groups (P > 0.05). Conclusion: Doing IUI 42 hours after hCG injection can significantly increase chances of fertility compared to doing it 36 hours after hCG injection.

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“…One study by Taerk et al reported that hCG administration significantly increased clinical pregnancy rates compared with monitoring of spontaneous serum LH surge in subfertile patients undergoing controlled ovarian hyperstimulation IUI cycles (22). Two additional retrospective studies of stimulated IUI have also reported that higher pregnancy rates resulted when hCG was given to trigger ovulation (23,24).…”

Section: Discussionmentioning

confidence: 98%

“…Several studies of ovarian hyperstimulation IUI cycles have demonstrated beneficial effects of hCG administration on IUI pregnancies (22)(23)(24). One study by Taerk et al reported that hCG administration significantly increased clinical pregnancy rates compared with monitoring of spontaneous serum LH surge in subfertile patients undergoing controlled ovarian hyperstimulation IUI cycles (22).…”

Section: Discussionmentioning

confidence: 99%

Effect of HCG-Triggered Ovulation on Pregnancy Outcomes in Intrauterine Insemination: An Analysis of 5,610 First IUI Natural Cycles With Donor Sperm in China

et al. 2020

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Objective: To evaluate the effect of human chorionic gonadotropin (hCG) trigger ovulation on pregnancy outcomes in natural IUI cycles with donor sperm. Methods: This retrospective cohort study included 5,610 first-natural IUI cycles with donor sperm in infertile couples during the period from January 2012 to December 2017. To control for other confounding factors, our analysis was restricted to normo-ovulatory women without tubal infertility. The main outcome measure was live birth rate; the secondary outcomes included rates of clinical pregnancy and miscarriage. Results: In the crude analysis, both the clinical pregnancy (27.40 vs. 22.73%; P = 0.001) and live birth rates (24.52 vs. 20.13%; P = 0.007) were significantly higher for the hCG group than for the spontaneous LH group. After adjustment for a number of confounding factors, the reproductive outcomes were still significantly worse for the spontaneous ovulatory group. Conclusions: Among women undergoing natural cycle IUI with donor sperm, hCG triggered ovulation for timing insemination offers beneficial impacts on both clinical pregnancy rates and live birth rates.

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Human chorionic gonadotropin administration is associated with high pregnancy rates during ovarian stimulation and timed intercourse or intrauterine insemination

Cited by 34 publications

References 37 publications

The impact of thyroid function on intrauterine insemination outcome - a retrospective analysis

The impact of thyroid function on intrauterine insemination outcome - a retrospective analysis

Comparing the Effectiveness of Doing Intra-uterine Insemination 36 and 42 Hours after Human Chorionic Gonadotropin (HCG) Injection on Pregnancy Rate: A Randomized Clinical Trial

Effect of HCG-Triggered Ovulation on Pregnancy Outcomes in Intrauterine Insemination: An Analysis of 5,610 First IUI Natural Cycles With Donor Sperm in China

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