Human chorionic gonadotropin-dependent expression of vascular endothelial growth factor/vascular permeability factor in human granulosa cells: importance in ovarian hyperstimulation syndrome

Neulen, Joseph

doi:10.1210/jc.80.6.1967

Cited by 147 publications

(136 citation statements)

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“…The presence of VEGF has recently been reported in ovarian follicles and ascitic fluid from patients with ovarian hyperstimulation syndrome, which is characterized by massive ascites and/or hydrothorax induced by gonadotropin treatment (Krasnow et al, 1996). This is thought to be the effect of VEGF on the permeability of vascular endothelium in the peritoneum or the ovary itself (Neulen et al, 1995). In an animal model of peritonitis carcinomatosa, VEGF accumulation in the peritoneal cavity paralleled tumour growth, increased the inflow of macromolecules from the plasma to the peritoneal cavity and the accumulation of ascitic fluid (Nagy et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

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Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels

Yamamoto

Konishi²,

Mandai³

et al. 1997

Br J Cancer

319

198

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Summary Vascular endothelial growth factor (VEGF) is known to be produced by various solid tumours and is thought to be involved in microvascular permeability and/or angiogenesis. To examine the relationship between VEGF expression in ovarian neoplasms and clinicopathological factors or patient survival, expression of VEGF was analysed immunohistochemically in 110 epithelial ovarian tumours. In addition, VEGF levels in the tumour fluid (17 patients), ascites (12 patients) and sera (38 patients) were determined using enzyme immunoassay. Positive immunostaining for VEGF was observed in 97% (68 out of 70) of ovarian carcinomas, which was significantly higher than that of tumours of low malignant potential (LMP) (13 out of 25; 52%) and benign cystadenomas (5 out of 15; 33%) (P < 0.01). In ovarian carcinomas, strong VEGF immunostaining was also observed more frequently in tumours of clear cell type (P < 0.05) in the advanced stage of disease (P < 0.05) and with positive peritoneal cytology (P < 0.01). Patients with strong VEGF staining had poorer survival rates than those with weak or no immunostaining for VEGF (P < 0.01). These findings suggest that strong VEGF expression plays an important role in the tumour progression of ovarian carcinoma. The enzyme immunoassay revealed higher serum VEGF levels in carcinoma patients than those in patients with LMP or benign tumours (P < 0.01). Serum VEGF levels decreased after the successful removal of tumours in ovarian cancer patients and, in one patient, the serum VEGF level was re-elevated during relapse. Therefore, serum VEGF could be used as a marker for monitoring the clinical course of ovarian cancer patients.

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Section: Discussionmentioning

confidence: 99%

“…This antibody is reported to react specifically with VEGF of mouse, rat and human origin and has been used previously for immunohistochemical investigation of VEGF localization in normal and neoplastic human tissues (Boocock et al, 1995;Harrison-Woolrych et al, 1995;Kamat et al, 1995;Neulen et al, 1995;Gordon et al, 1996).…”

Section: Immunohistochemistrymentioning

confidence: 99%

Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels

Yamamoto

Konishi²,

Mandai³

et al. 1997

Br J Cancer

319

198

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“…Ovarian hyperstimulation syndrome (OHSS) is a severe complication arising from controlled ovarian stimulation treatment (Neulen et al 1995). Clinical manifestations are massive extravascular fluid accumulation and hemoconcentration similar to that in syndromes associated with capillary leakage (Navot et al 1992, Neulen et al 1995.…”

Section: Introductionmentioning

confidence: 99%

“…Clinical manifestations are massive extravascular fluid accumulation and hemoconcentration similar to that in syndromes associated with capillary leakage (Navot et al 1992, Neulen et al 1995. Ascites formation in OHSS is provoked systemically by a mediator produced by the ovaries (Espey et al 1986, Navot et al 1992, Yarali et al 1993, McClure et al 1994, Neulen et al 1995. Although the pathophysiology of OHSS is still unknown, increased vascular permeability and ascites formation appear to be effects of vascular endothelial growth factor (VEGF) (Neulen et al 1995).…”

Section: Introductionmentioning

confidence: 99%

“…Ascites formation in OHSS is provoked systemically by a mediator produced by the ovaries (Espey et al 1986, Navot et al 1992, Yarali et al 1993, McClure et al 1994, Neulen et al 1995. Although the pathophysiology of OHSS is still unknown, increased vascular permeability and ascites formation appear to be effects of vascular endothelial growth factor (VEGF) (Neulen et al 1995). McClure et al (1994) reported that the major capillary permeability agent in ascites fluid in OHSS is VEGF, since at least 70% of the vascular permeability activity in OHSS is neutralized by an antiserum against intact VEGF.…”

Section: Introductionmentioning

confidence: 99%

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The kallikrein-kinin system, but not vascular endothelial growth factor, plays a role in the increased vascular permeability associated with ovarian hyperstimulation syndrome

Kobayashi

Okada²,

Asahina³

et al. 1998

Journal of Molecular Endocrinology

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Ovarian hyperstimulation syndrome (OHSS) is a severe complication arising from controlled stimulation treatment. Vascular endothelial growth factor (VEGF) has recently emerged as an important factor which may be responsible for the hyperpermeability seen in OHSS. The purpose of the present study was to investigate and compare the mechanisms by which ascites in patients with OHSS and ovarian carcinoma induce increases in vascular permeability in an in vitro assay and an in vivo animal experiment. We found 8-fold lower VEGF levels in ascites from patients with OHSS than in those from patients with ovarian carcinoma. Although VEGF is produced by the ovaries, it is not necessarily the factor responsible for hyperpermeability. We also demonstrated that the vascular hyperpermeability produced by OHSS ascites was not abolished by specific neutralizing anti-VEGF antibodies, and that not all of the VEGF found in the ascites fluid is biologically active. Moreover, our results strongly suggest that the vascular permeability produced by OHSS ascites may depend on activation of the kallikrein-kinin system. Possible evidence for this phenomenon was obtained by demonstrating that the hyperpermeability caused by the ascites could be blocked by Trasylol (known to inhibit bradykinin synthesis) and potentiated by captopril (a kininase II inhibitor). Taken together, the results suggest that, although VEGF is found in ascites fluid from patients with OHSS, it is unlikely that the cause of OHSS involves VEGF production by the ovaries. The kallikrein-kinin system may be more important in the hyperpermeability seen in OHSS.

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Implantation Window and Angiogenesis

Karizbodagh

Rashidi

Sahebkar

et al. 2017

J of Cellular Biochemistry

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In recent decades, infertility is one of the health problems worldwide. One of the most crucial events in reproductive period is implantation window (IW). In the time after IW period, the embryo cannot connect to the endometrium; therefore the most critical issue for successful implantation is timely entrance of embryo to the uterine cavity during the IW. Implantation failure is responsible for many cases of infertility and is the most important limiting factor for achieving a successful outcome using the assisted reproductive techniques (ART). The aim of this study was to investigate the receptivity of the endometrium and factors affecting it with emphasizing on the role of angiogenesis. Interaction between the embryo and the endometrium is affected by molecular interactions among cytokines, growth factors, hormones, and cell adhesion molecules, causing endometrial receptivity. Also, angiogenesis is a process that has an important role in human implantation. Estrogen and progesterone hormones are two important regulation keys in angiogenesis and implantation process. It is expected that effective and stimulating drugs of angiogenesis can improve the characteristics of endometrial receptivity and prevent implantation failure in ART. It is hoped that with recent advances in the field of molecular medicine, improvement of angiogenesis in human endometrium and prevention of the implantation failure be achieved. Here, we summarized various factors could affect on endometrial receptivity and the role of them on angiogenesis. J. Cell. Biochem. 118: 4141-4151, 2017. © 2017 Wiley Periodicals, Inc.

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Human chorionic gonadotropin-dependent expression of vascular endothelial growth factor/vascular permeability factor in human granulosa cells: importance in ovarian hyperstimulation syndrome

Cited by 147 publications

References 0 publications

Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels

Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels

The kallikrein-kinin system, but not vascular endothelial growth factor, plays a role in the increased vascular permeability associated with ovarian hyperstimulation syndrome

Implantation Window and Angiogenesis

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