Human Chorionic Gonadotropin Up-Regulates Expression of Myeloid Cell Leukemia-1 Protein in Human Granulosa-Lutein Cells: Implication of Corpus Luteum Rescue and Ovarian Hyperstimulation Syndrome

Chen, Shee‐Uan; Chen, Ruey-Jien; Shieh, Jeng-Yi; Chou, Chia-Hung; Lin, Chung-Wu; Lu, Hsin-Fen; Yang, Yu Shih

doi:10.1210/jc.2009-2596

Cited by 22 publications

(14 citation statements)

References 45 publications

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“…This suggests putrescine‐induced reactivation of luteal activity may be mediated through increased cell survival and thus preventing luteal cells from undergoing apoptosis. As it is well demonstrated that LH through its receptor (LH/hCG‐receptor) protects luteal cells from undergoing apoptosis during early pregnancy (Chen et al, ) and similarly in this study treatment with putrescine upregulated LHR, it is likely that putrescine via LHR contributes to reactivation of luteal activity by promoting cell survival and suppressing apoptosis.…”

Section: Discussionsupporting

confidence: 74%

Role of putrescine in ovary and embryo development in fruit bat Cynopterus sphinx during embryonic diapause

Anuradha

Banerjee

Krishna

2019

Molecular Reproduction Devel

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The aim of this study was to evaluate the effect of putrescine on ovarian activity and the rate of embryonic development in Cynopterus sphinx during delayed development. The result showed the presence of a rate‐limiting enzyme, ornithine decarboxylase‐1, in both ovary and utero‐embryonic unit of C. sphinx suggests a synthesis of putrescine in these sites. The corpus luteum showed increased, whereas utero‐embryonic unit showed decreased production of putrescine during delayed development as compared with the normal development. The bat treated in vivo with putrescine during delayed development showed increase in progesterone and estradiol synthesis, correlated with increased expression of luteinizing hormone receptor, steroidogenic acute receptor protein, and 3β‐hydroxysteroid dehydrogenase through extracellular signal‐regulated kinase (ERK1/2)‐mediated pathway in the ovary; but showed increase in the weight and expression of progesterone receptor (PR), B‐cell lymphoma 2, proliferating cell nucleus antigen, and vascular endothelial growth factor proteins in utero‐embryonic unit. The in vitro treatment of putrescine showed stimulatory whereas treatment with an inhibitor of putrescine, 2‐difluoromethylornithine caused an inhibitory effect on ovarian progesterone synthesis and cell proliferation, and cell survival in the utero‐embryonic unit. In conclusion, the putrescine showed two separate roles during embryonic diapause, high concentration of putrescine in the ovary may support corpus luteum and basal synthesis of progesterone, whereas a low level of putrescine causes retarded embryonic development by inhibiting cell proliferation in the utero‐embryonic unit. The bat treated with putrescine either directly promotes cell proliferation, cell survival, and angiogenic activities or acts indirectly increasing PR on utero‐embryonic unit thereby activating development in delayed embryo in C. sphinx.

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Section: Discussionsupporting

confidence: 74%

Role of putrescine in ovary and embryo development in fruit bat Cynopterus sphinx during embryonic diapause

Anuradha

Banerjee

Krishna

2019

Molecular Reproduction Devel

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“…Following a decline in LH support, hCG is the foremost leutotropic paracrine signal produced by the embryo, well before the implantation begins [7]. This hCG signaling critically influences the blastocyst development, uterine receptivity through stromal fibroblast proliferation, secretion of IGF binding protein-1, NK cell activation and apoptosis (Fas-FasL), transient immune tolerance through activation of regulatory T-cells and dendritic cells (MHC class II, IL-10 and IDO expression), and endometrial angiogenesis through secretion of VEGF [42,43].…”

Section: Discussionmentioning

confidence: 99%

“…One of the important aspects of the female reproductive cycle is that ovulation is controlled by a pulsatile secretion of LH (LH surge) that is subject to individual variation [3]. In controlled ovarian stimulation (COS), this variability of ovarian activities is temporarily eliminated by GnRH agonists/antagonists, while at the same time the ovarian functions are regulated by exogenously injected FSH and LH/hCG [4-7]. …”

Section: Introductionmentioning

confidence: 99%

Circulating LH/hCG receptor (LHCGR) may identify pre-treatment IVF patients at risk of OHSS and poor implantation

Chambers

Nayini

Mills

et al. 2011

Reprod Biol Endocrinol

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BackgroundSuccessful pregnancy via in vitro fertilization (IVF) depends on the recovery of an adequate number of healthy oocytes and on blastocyst implantation following uterine transfer. Two hormones, LH and hCG, utilize a common LH/hCG receptor (LHCGR), variations in which have profound implications in human reproduction. Soluble LHCGR (sLHCGR) is released from experimental cell lines and placental explants and it can be detected in the follicular fluid and serum.MethodsTo evaluate the impact of circulating soluble LHCGR (sLHCGR) in fertility treatment, we measured sLHCGR and LH-sLHCGR complex in serum from women seeking IVF using specifically developed quantitative enzyme-linked immunosorbent assays (ELISA). Following an IVF cycle of treatment, patients were grouped according to oocyte yield into low (lower than or equal to 7 oocytes), intermediate (8-14 oocytes) and high (greater than or equal to 15 oocytes) responders and pregnancy outcome noted.ResultsPre-treatment sLHCGR identified many women at risk of ovarian hyperstimulation. Low levels of sLHCGR were associated with pregnancy in both high and low responders but sLHCGR did not significantly affect the treatment outcome of intermediate responders. Low responders who failed to become pregnant had high levels of circulating sLHCGR bound to LH (LH-sLHCGR).ConclusionsPre-treatment measurement of sLHCGR could be used to tailor individual fertility treatment programs and improve outcomes by avoiding ovarian hyperstimulation and poor embryo implantation.

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“…The potential role of the VEGF/VEGF-receptor (VEGF-R1 and R2) system in the appearance of OHSS is based on certain evidence: a) it has been demonstrated that VEGF increases the vascular permeability of endothelial cells, which could lead to a shift in fluids from the blood vessels to the third space (26-28); b) vascular permeability increased after hCG during ovarian stimulation; c) the occurrence of OHSS is strongly correlated with the application of hCG during ovarian stimulation, leading to an increased VEGF expression by granulosa cells from corpora lutea (29-31) d) In OHSS patients, the amount of VEGF in the follicular fluid is frequently higher than in persons not affected by this complication (32), thus also proving the ovarian origin of VEGF; e) the VEGF-R2 expression increases at the same time that the vascular permeability peaks, demonstrating that the VEGF-VEGF receptor system is implicated in OHSS (27, 28). …”

Section: Phisiopathologymentioning

confidence: 99%

GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome

Alamá

Bellver

Vidal

et al. 2013

Int J Endocrinol Metab

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The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist for triggering final oocyte maturation, either together or separately, coasting, and the GnRH analogue may prove useful for avoiding OHSS in high-risk patients. We review these topics in this article.

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Human Chorionic Gonadotropin Up-Regulates Expression of Myeloid Cell Leukemia-1 Protein in Human Granulosa-Lutein Cells: Implication of Corpus Luteum Rescue and Ovarian Hyperstimulation Syndrome

Cited by 22 publications

References 45 publications

Role of putrescine in ovary and embryo development in fruit bat Cynopterus sphinx during embryonic diapause

Role of putrescine in ovary and embryo development in fruit bat Cynopterus sphinx during embryonic diapause

Circulating LH/hCG receptor (LHCGR) may identify pre-treatment IVF patients at risk of OHSS and poor implantation

GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome

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