Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor

Liu, Dazhen; Yin, Caihua; Zhang, Yingmei; Tian, Linjie; Li, Ting; Li, Dan; Ma, Dalong; Guo, Yinglu; Wang, Ying

doi:10.1007/s11434-009-0092-8

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Xuefeng Guo found that CMTM2 was downregulated in HCC tissues by immunohistochemistry, which is consistent with our study (Guo et al 2020 ). It has also been reported that inhibition of Akt activation and an increase in AR protein levels may be one of the mechanisms of enhanced CMTM2-mediated AR transactivation (Liu et al 2009 ). FH heterozygous mutations predispose to FH gene tumor susceptibility syndrome, characterized by cutaneous smooth muscle tumors, uterine smooth muscle tumors (leiomyosarcomas), or renal tumors.…”

Section: Discussionmentioning

confidence: 99%

Osteosarcoma neutrophil extracellular trap network-associated gene recurrence and metastasis model

Tang,

Xie,

et al. 2024

J Cancer Res Clin Oncol

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Osteosarcoma (OS) is the most common malignancy in children and adolescents and has a high probability of recurrence and metastasis. A growing number of studies have shown that neutrophil extracellular traps (NETs) are strongly associated with cancer metastasis, but in osteosarcoma, genes associated with NETs that promote osteosarcoma recurrence and metastasis remain to be explored. We systematically investigated the gene expression patterns of NETs in OS samples from the GEO database. NETs molecular typing was evaluated based on NETs expression profiles, and the association between NETs molecular subtypes and immune microenvironment and metastatic features were explored. Ultimately, we constructed a signature model and column line graph associated with metastasis prediction and screened possible potential drugs for metastatic osteosarcoma. We established two different molecular subtypes of NETs, which showed significant differences in metastatic status, metastasis time, tumor immune microenvironment, and biological effects. We also constructed a NETs-related gene metastasis signature(NRGMS) to assess the expression pattern of NETs in patients to predict metastatic recurrence in osteosarcoma patients. We screened for TOMM40 and FH associated with metastatic recurrence in osteosarcoma patients. Overall, this study constructs a predictive model for osteosarcoma metastasis of NETs-related genes, which is expected to provide new insights into the metastasis of osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

Osteosarcoma neutrophil extracellular trap network-associated gene recurrence and metastasis model

Tang,

Xie,

et al. 2024

J Cancer Res Clin Oncol

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“…In addition to THRAP3 , the positively-selected genes TH1L and CMTM6 may also help to explain the seasonal breeding behavior. As TH1L may have a similar function to TH1, which attenuates androgen signaling [ 68 ], while CMTM6 functions in spermatogenesis [ 69 – 71 ]. Evidence from previous studies suggests that orangutans produce 14 times less sperm than chimpanzees, which is a closely-related, but non-seasonal breeder [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Analysis of Positively Selected Genes in Seasonal and Non-Seasonal Breeding Species

et al. 2015

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Some mammals breed throughout the year, while others breed only at certain times of year. These differences in reproductive behavior can be explained by evolution. We identified positively-selected genes in two sets of species with different degrees of relatedness including seasonal and non-seasonal breeding species, using branch-site models. After stringent filtering by sum of pairs scoring, we revealed that more genes underwent positive selection in seasonal compared with non-seasonal breeding species. Positively-selected genes were verified by cDNA mapping of the positive sites with the corresponding cDNA sequences. The design of the evolutionary analysis can effectively lower the false-positive rate and thus identify valid positive genes. Validated, positively-selected genes, including CGA, DNAH1, INVS, and CD151, were related to reproductive behaviors such as spermatogenesis and cell proliferation in non-seasonal breeding species. Genes in seasonal breeding species, including THRAP3, TH1L, and CMTM6, may be related to the evolution of sperm and the circadian rhythm system. Identification of these positively-selected genes might help to identify the molecular mechanisms underlying seasonal and non-seasonal reproductive behaviors.

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Goat CMTM2: mRNA expression profiles of different alternative spliced variants and associations analyses with growth traits

Kang

et al. 2020

3 Biotech

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Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor

Cited by 3 publications

References 37 publications

Osteosarcoma neutrophil extracellular trap network-associated gene recurrence and metastasis model

Osteosarcoma neutrophil extracellular trap network-associated gene recurrence and metastasis model

Genome-Wide Analysis of Positively Selected Genes in Seasonal and Non-Seasonal Breeding Species

Goat CMTM2: mRNA expression profiles of different alternative spliced variants and associations analyses with growth traits

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