A new gesture-based visualization interaction design process model was proposed to support the method of gesturebased visualization interaction design in handheld devices. The development of handheld device, especially smart phones, usercentered interaction design theory and the circumstance of the application of gestures in handheld devices were studied. The example of And-Enjoy, which is an app based on android system, was shown to verify the effectiveness and practicality of the model through design evaluation.