Human Coronavirus Infections and Pregnancy

Fan, Shang­rong; Yan, Shao-Mei; Li, Xiaoping; Liu, Ping; Huang, Lei; Wang, Suhua

doi:10.1097/fm9.0000000000000071

Cited by 13 publications

(13 citation statements)

References 112 publications

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“…A second review study published in 2021 comparing outcomes between pregnant and non-pregnant women with SARS-CoV-2, MERS (Middle East respiratory syndrome coronavirus) and SARS (Severe acute respiratory syndrome coronavirus) concluded that there is no evidence that pregnant women are more susceptible to coronavirus infection in general, or that those infected with these viruses are more likely to develop severe pneumonia. Similar to non-pregnant women, pregnant women with MERS had the highest mortality, followed by those with SARS and COVID-19 [33]. These findings are corroborated by a retrospective and multicentric cohort carried out in 2020 [34] in which it was observed that the mortality rate among pregnant women (110 patients) compared to non-pregnant women (224 patients) did not show statistically significant differences.…”

Section: Discussionsupporting

confidence: 52%

Analysis of the Factors That Influence the Clinical Outcome of Severe Acute Respiratory Syndrome Caused by SARS-CoV-2 in Pregnant Women

Cavalcante¹,

Chaves²,

Moreira³

et al. 2022

Contemporary Developments and Perspectives in International Health Security - Volume 3

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Introduction: The new coronavirus (SARS-CoV-2) pandemic has shown to cause even more severe problems among pregnant women, increasing the incidence of complications before and after childbirth, especially cardiorespiratory problems, such as the Severe Acute Respiratory Syndrome (SARS). Objectives: To describe the clinical outcome of SARS caused by SARS-CoV-2 in Brazilian pregnant women and to compare the rates of morbidity and mortality from other causes in this group, stratified by the following variables: gestational age and age group. Methodology: Observational, analytical study based on documents whose data were collected from the 2020 Epidemiological Report No. 40 in the database of the Brazilian Department of Health, from which morbidity and mortality data were extracted to calculate the lethality rate and compare rates using a binomial test with a significance level of 0.05. Results: Of the total number of pregnant women hospitalized for SARS, 4,467 (46.6%) were confirmed for COVID-19 and, of these, 233 died, corresponding to a lethality rate of 5.2%. Morbidity was higher in the third trimester of pregnancy, but the disease was more severe in the second trimester (7%), being worse in women aged 40 years and older (40–49; 8.7% and 50–59; 15.3%). A significant difference was observed in the rate of cases between the COVID-19 SARS group and the group with other causes in all gestational strata and age groups. As for deaths, a significant difference was found in the rates between the first and third trimesters, and in pregnant women aged 10 to 19 years. Conclusion: Considering the variables under analysis, evidence shows that pregnant women at an advanced age and in the second trimester of pregnancy contribute to the lethal outcome of the disease. Other variables associated with the presence of comorbidities and quality of care for pregnant women should be considered in the model in future studies.

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Section: Discussionsupporting

confidence: 52%

Analysis of the Factors That Influence the Clinical Outcome of Severe Acute Respiratory Syndrome Caused by SARS-CoV-2 in Pregnant Women

Cavalcante¹,

Chaves²,

Moreira³

et al. 2022

Contemporary Developments and Perspectives in International Health Security - Volume 3

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“…The Chinese guidelines highlight the separation of the newborn from the mother and no maternal breast milk use [ 28 ]. Newborns born to mothers with confirmed SARS-CoV-2 infection should be considered patients under investigation until test results arrive [ 29 ]. As the pandemic started, our Clinic of Neonatology approach was to separate the mother and infant at birth and require breastfeeding.…”

Section: Discussionmentioning

confidence: 99%

First Neonates with Vertical Transmission of SARS-CoV-2 Infection in Late Pregnancy in West Part of Romania: Case Series

et al. 2022

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The Coronavirus disease 2019 (COVID-19) pandemic has exposed the vulnerable neonatal population to unknown risks. Given that herd immunity is has not been reached, the entire population is susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 Virus(SARS-CoV-2) infection. The arising concern about the vertical transmission of neonatal complications caused by the novel coronavirus is a continuous challenge for managing newborns, considering the rare cases and unclear guidelines. Therefore, a retrospective study was conducted in a tertiary unit from Timisoara, Romania. Of the 283 newborns born during the study period, only 3 neonates were diagnosed with SARS-CoV-2 infection in the first 24 h of life (DOL-0). The present study plans to identify the findings, including clinical features, laboratory characteristics, and outcomes of newborns with vertical transmission of SARS-CoV-2. All infected neonates were confirmed with COVID-19 by Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) from nasal aspirates and were isolated in the neonatology department. They were the first and the only neonate infected at birth from the West part of Romania. The clinical findings were unremarkable except for one neonate who developed mild respiratory distress syndrome. Elevated IgG-specific anti-SARS-CoV-2 serum levels were found in one newborn. Swab samples in DOL-0 strengthened the awareness of vertical transmission, although peripartum SARS-CoV-2 infection does not seem responsible for severe symptoms. We conclude that vertical transmission is rare in late pregnancy. Even if the studied newborns showed mild forms of COVID-19, it is essential to note that newborns represent a particular category of patients. More studies are needed to complete the observations of this study.

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“…Some studies have reported that SARS-CoV-2 infection in pregnant women behaves similarly to the general population, contrary to what has been reported with other types of coronavirus infection in the past ( Li N. et al, 2020 ; Yang et al, 2020 ; Fan et al, 2021 ). The disease manifests itself with typical symptoms and occurs with different degrees of severity, such as mild disease in 81–86% of cases, severe disease in 9.3–14%, and critical disease in 5%; values close to those reported in the general population (80, 15, and 5%, respectively) ( Han et al, 2020 ).…”

Section: Clinical Presentation Of Severe Acute Respiratory Syndrome C...mentioning

confidence: 67%

Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy. A Non-systematic Review of Clinical Presentation, Potential Effects of Physiological Adaptations in Pregnancy, and Placental Vascular Alterations

et al. 2022

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In December 2019, the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) rapidly spread to become a pandemic. To date, increasing evidence has described the potential negative impact of SARS-CoV-2 infection on pregnant women. Although the pathophysiology of coronavirus disease 2019 (COVID-19) is not entirely understood, there is emerging evidence that it causes a severe systemic inflammatory response associated with vascular alterations that could be of special interest considering some physiological changes in pregnancy. Additionally, these alterations may affect the physiology of the placenta and are associated with pregnancy complications and abnormal histologic findings. On the other hand, data about the vaccine against SARS-CoV-2 are limited, but the risks of administering COVID-19 vaccines during pregnancy appear to be minimal. This review summarizes the current literature on SARSCoV2 virus infection, the development of COVID-19 and its relationship with physiological changes, and angiotensin-converting enzyme 2 (ACE2) function during pregnancy. We have particularly emphasized evidence coming from Latin American countries.

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Human Coronavirus Infections and Pregnancy

Cited by 13 publications

References 112 publications

Analysis of the Factors That Influence the Clinical Outcome of Severe Acute Respiratory Syndrome Caused by SARS-CoV-2 in Pregnant Women

Analysis of the Factors That Influence the Clinical Outcome of Severe Acute Respiratory Syndrome Caused by SARS-CoV-2 in Pregnant Women

First Neonates with Vertical Transmission of SARS-CoV-2 Infection in Late Pregnancy in West Part of Romania: Case Series

Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy. A Non-systematic Review of Clinical Presentation, Potential Effects of Physiological Adaptations in Pregnancy, and Placental Vascular Alterations

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