2009
DOI: 10.1016/s0929-6646(09)60066-8
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Human Coronaviruses 229E and NL63: Close Yet Still So Far

Abstract: HCoV-NL63 and HCoV-229E are two of the four human coronaviruses that circulate worldwide. These two viruses are unique in their relationship towards each other. Phylogenetically, the viruses are more closely related to each other than to any other human coronavirus, yet they only share 65% sequence identity. Moreover, the viruses use different receptors to enter their target cell. HCoV-NL63 is associated with croup in children, whereas all signs suggest that the virus probably causes the common cold in healthy… Show more

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Cited by 54 publications
(46 citation statements)
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“…bovine coronavirus) and human (e.g. SARS-CoV, HCoV-OC43, HCoV-229E) diseases [21][22][23][24]. MHV is a group II coronavirus that has long been used as a tool for studying coronavirus biology and pathogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…bovine coronavirus) and human (e.g. SARS-CoV, HCoV-OC43, HCoV-229E) diseases [21][22][23][24]. MHV is a group II coronavirus that has long been used as a tool for studying coronavirus biology and pathogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Coronaviruses are large enveloped single-stranded RNA viruses that can infect birds and mammals [3]. Since the mid-1960s, human coronaviruses were known for causing common cold (HcoV-229 and OC43), and in the 2000s they were found to cause bronchiolitis (NL63) and pneumonia mainly during the SARS epidemic (HKU-1 and SARS-CoV) [4]. Although asymptomatic infections have been reported, the MERS-CoV causes severe pneumonia with acute respiratory distress and multiple-organ failure leading to a high mortality rate [5].…”
Section: Introductionmentioning
confidence: 99%
“…HCoV-229E and HCoV-NL63 belong to the alphacoronavirus group and are the only two human CoVs that have a relatively close phylogenetic relationship (5). HCoV-229E was discovered in the mid-1960s from persons with the common cold, and HCoV-NL63 was isolated for the first time in 2004 from a 7-month-old infant with bronchiolitis (9,28).…”
mentioning
confidence: 99%