Human coronaviruses and therapeutic drug discovery

Song, Liying; Xie, Qingxing; Lao, Hui-Lin; Lv, Ziquan

doi:10.1186/s40249-021-00812-9

Cited by 18 publications

(18 citation statements)

References 141 publications

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“…The issue of coronavirus nowadays is of serious concern. The analysis of scientific databases has revealed many literature reviews describing the effects of polyphenols as antiviral antioxidants that support the immune system [8,[57][58][59][60][65][66][67][68].…”

Section: Coronavirusmentioning

confidence: 99%

“…Only about 8% of patients experienced mild adverse events [7]. Another study showed that as many as 53% of patients treated with Polyphenon E 15% were completely cured of primary and new anal and genital warts (about 60% of women and 45% of men), while adverse effects occurred only at the application site [8]. Approximately 60% complete removal of warts, with 10% recurrence of the disease, was found using 10% and 15% sinecatechin-containing ointment.…”

Section: Clinical Trialsmentioning

confidence: 99%

“…Especially, during the ongoing COVID-19 pandemic and due to the lack of efficient treatment, scientists are trying to develop new preparations to inhibit the penetration and replication of pathogens from the coronavirus family, especially the spread of SARS-CoV-2 (severe acute respiratory syndrome) [7]. Having collected data from scientific sources, patents and clinical trials, Song et al (2021) have shown that Chinese herbal medicines (mixtures containing, among others, ginger, ginkgo, sage) can block the enzymatic activity of 3CLpro [8]. Acorns and their extracts can also inhibit SARS-CoV-2 replication due to high concentrations of gallic acid [9].…”

Section: Introductionmentioning

confidence: 99%

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Antiviral Properties of Polyphenols from Plants

Chojnacka

Skrzypczak

Izydorczyk

et al. 2021

Foods

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Polyphenols are active substances against various types of viral infections. Researchers have characterized methods of how to isolate polyphenols without losing their potential to formulate pharmaceutical products. Researchers have also described mechanisms against common viral infections (i.e., influenza, herpes, hepatitis, rotavirus, coronavirus). Particular compounds have been discussed together with the plants in the biomass in which they occur. Quercetin, gallic acid and epigallocatechin are exemplary compounds that inhibit the growth cycle of viruses. Special attention has been paid to identify plants and polyphenols that can be efficient against coronavirus infections. It has been proven that polyphenols present in the diet and in pharmaceuticals protect us from viral infections and, in case of infection, support the healing process by various mechanisms, i.e., they block the entry into the host cells, inhibit the multiplication of the virus, seal blood vessels and protect against superinfection.

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Section: Coronavirusmentioning

confidence: 99%

Section: Clinical Trialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antiviral Properties of Polyphenols from Plants

Chojnacka

Skrzypczak

Izydorczyk

et al. 2021

Foods

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“…Even with numerous in silico studies demonstrating the binding of various flavonoids to integral viral proteins or the human ACE-2 receptor of the SARS-CoV-2 virus, and another batch of studies promoting the effectiveness of various nanodelivery systems, thus far there has been not a single discovery of a flavonoid or for that matter any other compound and a nanodelivery system as an anti-SARS-CoV-2 drug with an efficacious delivery system. To quote a recent review, "well-designed high-quality studies are needed to further study the effectiveness and safety of these potential drugs in order to provide valid recommendations for better control of the COVID-19 pandemic" [371].…”

Section: Discussionmentioning

confidence: 99%

Nanotechnology Applications of Flavonoids for Viral Diseases

et al. 2021

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Recent years have witnessed the emergence of several viral diseases, including various zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Other viruses, which possess pandemic-causing potential include avian flu, Ebola, dengue, Zika, and Nipah virus, as well as the re-emergence of SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) coronaviruses. Notably, effective drugs or vaccines against these viruses are still to be discovered. All the newly approved vaccines against the SARS-CoV-2-induced disease COVID-19 possess real-time possibility of becoming obsolete because of the development of ‘variants of concern’. Flavonoids are being increasingly recognized as prophylactic and therapeutic agents against emerging and old viral diseases. Around 10,000 natural flavonoid compounds have been identified, being phytochemicals, all plant-based. Flavonoids have been reported to have lesser side effects than conventional anti-viral agents and are effective against more viral diseases than currently used anti-virals. Despite their abundance in plants, which are a part of human diet, flavonoids have the problem of low bioavailability. Various attempts are in progress to increase the bioavailability of flavonoids, one of the promising fields being nanotechnology. This review is a narrative of some anti-viral dietary flavonoids, their bioavailability, and various means with an emphasis on the nanotechnology system(s) being experimented with to deliver anti-viral flavonoids, whose systems show potential in the efficient delivery of flavonoids, resulting in increased bioavailability.

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“…[ 4 , 5 ] The incubation period is generally from 1 to 14 days, and up to now, there exists no effective confirmed antiviral therapy. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

Effects of music therapy on COVID-19 patients’ anxiety, depression, and life quality

Chen

Li²,

Zheng³

et al. 2021

Medicine

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Background: Whether music therapy improves coronavirus disease 2019 (COVID-19) patients’ anxiety, depression, and life quality are still controversial. Therefore, to provide evidence-based medical evidence for clinical non-pharmacological interventions, we performed a meta-analysis of randomized controlled trials of music therapy for COVID-19 patients’ anxiety, depression, and life quality. Methods: Cochrane Central Register of Controlled Trials Repositories, PubMed, Embase, Web of Science and Chinese Science Citation Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific Journal Database, and Wan-Fang database were searched to identify studies on the evaluation of the effectiveness of the music-based intervention on COVID-19 patients’ anxiety, depression, and life quality from inception to May 2021. Two researchers independently carried out data extraction and literature quality evaluation of the quality and the meta-analysis on the included literature was performed with Revman5.3 software. Results: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. Conclusion: This study will provide reliable evidence-based evidence for the effects of music therapy on COVID-19 patients’ anxiety, depression, and life quality.

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Human coronaviruses and therapeutic drug discovery

Cited by 18 publications

References 141 publications

Antiviral Properties of Polyphenols from Plants

Antiviral Properties of Polyphenols from Plants

Nanotechnology Applications of Flavonoids for Viral Diseases

Effects of music therapy on COVID-19 patients’ anxiety, depression, and life quality

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