Human cutaneous vulvar reactivity to irritants

Britz, Marie B.; Maibach, Howard I.

doi:10.1111/j.1600-0536.1979.tb04908.x

Cited by 101 publications

(38 citation statements)

References 3 publications

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“…Britz and Maibach [8] used two irritants, benzalkonium chloride (17%) and maleic acid (20%), for their ability to induce erythema without gross destruction of skin. These chemicals were applied at the labia majora and ventral forearm unoccluded.…”

Section: Irritant Reactivity Of Vulvar Skinmentioning

confidence: 99%

Vulvar Dermatoses – Irritant and Allergic Contact Dermatitis of the Vulva

et al. 2005

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Irritant and allergic contact dermatitis are commonly seen in patients complaining about itching, burning and irritation in the vulvar area. Irritation often precedes allergic sensitization. Clinically, irritant and allergic contact dermatitis can be difficult to distinguish. Diagnosis is made by history, clinical investigation and patch testing. Recommended patch test series are the standard series, a medicament series, the patient’s own topical medicaments, popular remedies and other suspected products. A skin biopsy may be useful to establish the diagnosis of contact dermatitis, but it is usually not helpful for the differential diagnosis between irritant and allergic dermatitis.

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Section: Irritant Reactivity Of Vulvar Skinmentioning

confidence: 99%

Vulvar Dermatoses – Irritant and Allergic Contact Dermatitis of the Vulva

et al. 2005

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“…the forearm) is not predictive for the objective assessment of irritant dermatitis of the vulva, we sought to establish a standard procedure for assessing vulvar skin TEWL [11][12][13]. In this way, TEWL could be used as an indicator for the integrity and clinical status of vulvar skin.…”

Section: Introductionmentioning

confidence: 99%

Transepidermal Water Loss Dynamics of Human Vulvar and Thigh Skin

Warren

Bauer

Greif

et al. 2005

Skin Pharmacol Physiol

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Refinement in procedures to assess skin surface water loss (SSWL) dynamics of the vulvar skin on a large sample of subjects (60) is described and compared to another semi-occluded skin site, the inner thigh. Vulvar SSWL significantly decreased over a 30-min period from 46.2 ± 2.6 (SE) to 24.7 ± 1.6 g m^–2 h (p < 0.001). The inner thigh, another semi-occluded region, showed no similar pattern for SSWL (6.2 ± 0.3 to 6.6 ± 0.5 g m^–2 h), and the values were significantly less than those for vulvar skin. There was no significant effect of age, body mass index or atopic status on vulvar SSWL.

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“…Vulval skin has been shown to be more liable to the adverse effects of irritants compared with skin elsewhere [6,7]. In those studies addressing contact allergy affecting the vulva there have been wide variations in the proportions of patients with relevant allergic reactions ranging from 19 to 58% [3,4,8,9].…”

Section: Discussionmentioning

confidence: 99%

The Role of Patch Testing in Perineal Disorders Affecting Women

Batchelor¹,

Young²,

Beck³

2003

Exog Dermatol

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Background: Many different materials are used in the perineal area, making it liable to contact sensitisation. Objective: We report the results of a retrospective study of patients with perineal dermatoses involving the vulva investigated for possible contact allergy. Methods: 240 female patients with dermatoses in the perineal area, specifically including the vulva, were patch tested to our standard series and a special patch test series devised for perineal problems. Results: 79 out of 240 patients (32.9%) demonstrated relevant positive results. These related to medicaments (49 patients), perfumes (22 patients), cosmetics (5 patients), dyes (4 patients) and rubber (4 patients). Conclusions: Perineal dermatoses involving the vulva may require patch testing to identify suspected and unanticipated contact allergy. An extended comprehensive series of patch test allergens will be necessary in these cases.

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Human cutaneous vulvar reactivity to irritants

Cited by 101 publications

References 3 publications

Vulvar Dermatoses – Irritant and Allergic Contact Dermatitis of the Vulva

Vulvar Dermatoses – Irritant and Allergic Contact Dermatitis of the Vulva

Transepidermal Water Loss Dynamics of Human Vulvar and Thigh Skin

The Role of Patch Testing in Perineal Disorders Affecting Women

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