Abstract:Cytokine receptor like factor 3 (CRLF3) is a conserved cytokine receptor present in all major eumetazoan taxa. Though vertebrate CRLF3 has recently been implied in the regulation of hematopoiesis, its ligand remained unidentified. CRLF3 shares structural similarity with receptors for other hematopoietic growth factors including erythropoietin, thrombopoietin and granulocyte colony-stimulating factor. Besides hematopoietic organs, these established hematopoietic cytokines and their receptors are also widely exp… Show more
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