Human cytomegalovirus detection in gastric cancer and its possible association with lymphatic metastasis

Zhang, Liang; Guo, Gangqiang; Xu, Jianfeng; Sun, Xia; Chen, Wenjing; Jin, Jinji; Hu, Changyuan; Zhang, Peichen; Shen, Xian; Xue, Xiangyang

doi:10.1016/j.diagmicrobio.2017.02.001

Cited by 32 publications

(38 citation statements)

References 34 publications

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“…Five studies sought to detect HCMV in GC with 682 samples (265 for cases with GC, 417 for noncancer controls) ( 10 , 26 , 30 , 37 , 51 ). The pooled HCMV prevalence in GC was 43.1% (95% CI 14.2%–72.0%, random model, heterogeneity P < 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…Wei et al believed that evidence supporting the interaction between HBV and H. pylori was insufficient ( 9 , 82 , 83 ). Fattahi et al found that HCMV viral loads were much higher in H. pylori -negative tissues compared with those in H. pylori -positive tissues, and the prevalence of H. pylori was lower in tumor tissues than that in nontumor tissues for GC ( 26 , 84 ). No correlation between HPV and H. pylori or EBV infection in gastric carcinogenesis was found in previous studies too ( 12 , 13 , 49 ).…”

Section: Discussionmentioning

confidence: 99%

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Associations Between Gastric Cancer Risk and Virus Infection Other Than Epstein-Barr Virus: A Systematic Review and Meta-analysis Based on Epidemiological Studies

Wang

Chen

et al. 2020

Clin Transl Gastroenterol

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INTRODUCTION: Besides Helicobacter pylori and Epstein-Barr virus, other viruses might play potential roles in gastric carcinogenesis. This systematic review and meta-analysis was conducted to compare the prevalence of the viruses between gastric cancer (GC) and any controls. METHODS: Comprehensive literature was searched up to January 25, 2019, and search was updated on April 6, 2020. The studies that compared the prevalence of viruses other than Epstein-Barr virus between GC and healthy or nonmalignant controls were eligible. Stata 12.0 software was used for heterogeneity tests and meta-analyses. Meanwhile, subgroup analysis, sensitivity analysis, and publication bias evaluation were performed where applicable. The power (1–β) was estimated by the PASS 11 software for each individual study. RESULTS: A total of 41 eligible studies were included, concerning 11 kinds of viruses. Prevalence were significantly higher in GC for hepatitis B virus (odds ratio [OR] = 1.39, 95% confidence interval [CI] 1.11–1.75), human cytomegalovirus (OR = 2.25, 95% CI 1.14–4.43), human papillomavirus (HPV) (OR = 1.63, 95% CI 1.05–2.54), and John Cunningham virus (OR = 2.52, 95% CI 1.26–5.04). In subgroup analyses, HPV-16 infection was significantly associated with GC (OR = 2.42, 95% CI 1.00–5.83). DISCUSSION: This study demonstrated that hepatitis B virus, human cytomegalovirus, HPV, and John Cunningham virus were more prevalent in GC. However, the causal relationship between their infection and risk of GC remains inconclusive, and further investigations are required.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Associations Between Gastric Cancer Risk and Virus Infection Other Than Epstein-Barr Virus: A Systematic Review and Meta-analysis Based on Epidemiological Studies

Wang

Chen

et al. 2020

Clin Transl Gastroenterol

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“…The detailed evaluation of the 67 remaining studies resulted in the further exclusion of 57 due to duplicated publications, lack of adequate data, or no original date for the meta-analysis. Finally, 10 publications were included in our meta-analysis [11,[16][17][18][19][20][21][22][23][24]. The study selection process has been depicted as a flow chart in online supplementary Figure 1 (for all online suppl.…”

Section: Meta-analysis Of Hcmv Prevalencementioning

confidence: 99%

Cytomegalovirus Infection Is a Risk Factor in Gastrointestinal Cancer: A Cross-Sectional and Meta-Analysis Study

Han

An³

et al. 2020

Intervirology

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Background: This study was planned to investigate the association betweenhuman cytomegalovirus (HCMV) infection and gastrointestinal cancer (GIC) risk, by undertaking a meta-analysis and case-control cross-sectional study. Summary: A cross-sectional study analysis of 160 GIC patients and 100 control subjects indicated significantly higher HCMV prevalence in GIC patients based on the HCMV IgM test. However, a similar analysis based on an IgG test revealed no significant relationship. Further meta-analysis of 11 studies, including 1,044 patients and 991 healthy subjects, displayed HCMV infection as an important risk factor for not only colorectal cancer occurrence and development based on a HCMV DNA test, but also for GIC based on a HCMV IgM test. However, the IgG test again displayed no significant relationship between HCMV infection and GIC occurrence. Key Message: Overall, our study revealed that HCMV infection is associated with an increased GIC risk. However, additional studies are warranted to elucidate the molecular mechanism underlying this association.

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“…In the last two decades, HCMV has been reported to serve an important role in the neoplastic process of human malignant tumors, such as glioblastoma, salivary gland cancer, lung carcinoma, breast cancer, prostatic carcinoma, colorectal cancer and hepatocellular carcinoma (8)(9)(10)(11)(12)(13)(14). Our previous study revealed that HCMV was present in 50-69.61% of GC tissues (15). However, only a few studies have focused on the effect of HCMV on GC.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have revealed a difference in the expression levels of the UL133, UL135, UL136 and UL138 genes between normal gastric and tumor tissues (16,17). Additionally, an association between HCMV infection and lymphatic metastasis was observed in GC (15). Considering the high prevalence of H. pylori and its role in GC, the synergetic or antagonistic effects between HCMV and H. pylori could not be ignored when investigating the role of HCMV in GC.…”

Section: Introductionmentioning

confidence: 99%

Patients with Helicobacter pylori‑positive gastric cancer with human cytomegalovirus infection have a low tendency of advanced lymphatic metastasis in a Chinese population

Chen

Zheng

et al. 2021

Oncol Lett

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Recognized as a group I carcinogen for gastric cancer (GC) and a factor involved in the development of GC, Helicobacter pylori serves a major part in GC research. However, most studies have focused on H. pylori itself, ignoring the complicated pathogenic microbiological environment of GC and neglecting the synergistic or antagonistic effects of H. pylori with other pathogenic microorganisms. Increasing evidence has revealed that the human cytomegalovirus (HCMV) is present in several types of tumors and serves an important role in the neoplastic process of certain human malignant tumors, including GC. The aim of the present study was to explore the role of HCMV and H. pylori co-infection in GC. HCMV and H. pylori infection was analyzed in paired gastric tumor and peri-tumoral tissues from 134 (98 male and 36 female) patients using PCR. The results revealed that a total of 74 (55.2%) patients had H. pylori infection, 58 patients (43.3%) had HCMV infection, and 34 (25.4%) patients had both HCMV and H. pylori infection. Univariate and multivariate analyses demonstrated that H. pylori infection was independently associated with advanced lymphatic metastasis [P=0.007; odds ratio (OR)=3.51]. Furthermore, compared with HCMV-/H. pylori-, neither HCMV + /H. pylorinor HCMV + /H. pylori + were associated with metastasis, but HCMV-/H. pylori + co-infection status was an independent risk factor for advanced lymphatic metastasis (P=0.005; OR=6.00). In conclusion, GC co-infected with HCMV and H. pylori exhibited a low tendency of lymph node metastasis. HCMV may interact with H. pylori to inhibit the process of lymphatic metastasis, and the mechanism requires further investigation.

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Human cytomegalovirus detection in gastric cancer and its possible association with lymphatic metastasis

Cited by 32 publications

References 34 publications

Associations Between Gastric Cancer Risk and Virus Infection Other Than Epstein-Barr Virus: A Systematic Review and Meta-analysis Based on Epidemiological Studies

Associations Between Gastric Cancer Risk and Virus Infection Other Than Epstein-Barr Virus: A Systematic Review and Meta-analysis Based on Epidemiological Studies

Cytomegalovirus Infection Is a Risk Factor in Gastrointestinal Cancer: A Cross-Sectional and Meta-Analysis Study

Patients with Helicobacter pylori‑positive gastric cancer with human cytomegalovirus infection have a low tendency of advanced lymphatic metastasis in a Chinese population

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