2021
DOI: 10.3389/fnagi.2021.720582
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Human Cytomegalovirus Immediate Early Protein 2 Protein Causes Cognitive Disorder by Damaging Synaptic Plasticity in Human Cytomegalovirus-UL122-Tg Mice

Abstract: Human cytomegalovirus (HCMV) infection is very common in the human population all around the world. Although the majority of HCMV infections are asymptomatic, they can cause neurologic deficits. Previous studies have shown that immediate early protein 2 (IE2, also known as UL122) of HCMV is related with the cognitive disorder mechanism. Due to species isolation, a HCMV-infected animal model could not be established which meant a study into the long-term effects of IE2 on neural development could not be carried… Show more

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Cited by 4 publications
(7 citation statements)
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“…5 and 6 ). The single-cell sequencing data provided us with partial evidence of the correlation between HCMV and neurodegenerative disease, which explained the learning and memory impairment observed in IE2 transgenic mice in previous studies [ 9 , 42 ]. Taken together, this evidence shows that microglia may also function as an element of the adaptive immune system with the IE2 expression.…”
Section: Discussionmentioning
confidence: 65%
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“…5 and 6 ). The single-cell sequencing data provided us with partial evidence of the correlation between HCMV and neurodegenerative disease, which explained the learning and memory impairment observed in IE2 transgenic mice in previous studies [ 9 , 42 ]. Taken together, this evidence shows that microglia may also function as an element of the adaptive immune system with the IE2 expression.…”
Section: Discussionmentioning
confidence: 65%
“…The CMV-specific serum IgG antibody level has been found to be significantly correlated with NFT formation, and CMV infection has been found to markedly induce the formation of Aβ plaques[ 31 ]. IE2, immediately-early protein of HCMV, has been shown to affect brain development and cognition in mice, which manifests as synapse loss in the hippocampus and cerebral cortex, leading to learning and cognitive impairment [ 9 ].…”
Section: Discussionmentioning
confidence: 99%
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