Human cytomegalovirus infection of the gastrointestinal tract in apparently immunocompetent patients

Maiorana, Antonio; Baccarini, Paola; Foroni, Moira; Bellini, N; Giusti, Federica

doi:10.1016/j.humpath.2003.08.005

Cited by 43 publications

(33 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CMV infection has been detected in colonic epithelial cells of immunocompromised patients (17,18) as well as immunocompetent individuals (19). To date, all information regarding the physiological importance of US28 is based on in vitro models.…”

Section: Introductionmentioning

confidence: 99%

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice

Bongers¹,

Maussang²,

Muniz³

et al. 2010

J. Clin. Invest.

112

View full text Add to dashboard Cite

US28 is a constitutively active chemokine receptor encoded by CMV (also referred to as human herpesvirus 5), a highly prevalent human virus that infects a broad spectrum of cells, including intestinal epithelial cells (IECs). To study the role of US28 in vivo, we created transgenic mice (VS28 mice) in which US28 expression was targeted to IECs. Expression of US28 was detected in all IECs of the small and large intestine, including in cells expressing leucine rich repeat containing GPCR5 (Lgr5), a marker gene of intestinal epithelial stem cells. US28 expression in IECs inhibited glycogen synthase 3β (GSK-3β) function, promoted accumulation of β-catenin protein, and increased expression of Wnt target genes involved in the control of the cell proliferation. VS28 mice showed a hyperplastic intestinal epithelium and, strikingly, developed adenomas and adenocarcinomas by 40 weeks of age. When exposed to an inflammation-driven tumor model (azoxymethane/dextran sodium sulfate), VS28 mice developed a significantly higher tumor burden than control littermates. Transgenic coexpression of the US28 ligand CCL2 (an inflammatory chemokine) increased IEC proliferation as well as tumor burden, suggesting that the oncogenic activity of US28 can be modulated by inflammatory factors. Together, these results indicate that expression of US28 promotes development of intestinal dysplasia and cancer in transgenic mice and suggest that CMV infection may facilitate development of intestinal neoplasia in humans.

show abstract

Section: Introductionmentioning

confidence: 99%

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice

Bongers¹,

Maussang²,

Muniz³

et al. 2010

J. Clin. Invest.

112

View full text Add to dashboard Cite

show abstract

“…Maiorana et al [8] reported a study of 11 cases of gastrointestinal tract infection by CMV, 6 located in the colon, 4 in the stomach and 1 in the esophagus in immunocompetent patients. In 4 of them, malignant tumors were detected between 2 and 5 months after the diagnosis of the infection.…”

Section: Discussionmentioning

confidence: 99%

“…One patient developed lung cancer, but the others adenocarcinoma of the common hepatic duct, pancreatic carcinoma and adenocarcinoma of Vater’s ampulla. Maiorana et al [8] postulated that the neoplastic state may induce an as yet unidentified immunological defect that favors the CMV infection. Mainly in elderly patients, the diagnosis of CMV infection might compel to continue the studies to exclude an underlying tumor.…”

Section: Discussionmentioning

confidence: 99%

Distal Cholangiocarcinoma Associated with Papillitis with Viral CMV Inclusions

Ruíz-Tóvar

Martín-Pérez²,

Gamallo-Amat³

2005

Dig Surg

View full text Add to dashboard Cite

Cytomegalovirus (CMV) infections are usually described in immunodeficient patients. In immunocompetent patients active infection is uncommon, consisting usually of a mononucleosis-like syndrome. Numerous reports show that CMV is a potential pathogen in the gastrointestinal tract, even in immunocompetent patients, where it can produce lesions from the mouth to the anus. We report herein an uncommon association of chronic inflammation of the papilla and viral CMV inclusions with distal cholangiocarcinoma in a 72-year-old woman who presented jaundice, choluria, acholia and generalized pruritus. At laparotomy, dilatation of the bile ducts and an enlarged head of the pancreas were found. Pancreatoduodenectomy was performed. Pathology revealed an enlarged papilla, due to chronic inflammation with CMV inclusions. Histological analysis revealed moderately differentiated ductal adenocarcinoma of the distal bile tract.

show abstract

“…Several studies demonstrated that advanced age is a risk factor for CMV disease in immunocompetent patients, in line with immune senescence [2,3,8,18] . In addition, critical conditions or comorbidities can play a role in patients without immunodeficiency or immunosuppression, causing significant impairment of host immune response [2,3,5,8,13,18] . Marques et al [17] also reported advanced age and those conditions in all immunocompetent patients.…”

mentioning

confidence: 96%

“…In immunocompetent patients, CMV disease is rare even when viral shedding occurs, because cell-mediated host immune response (CD8+ cytotoxic T lymphocytes and memory T cells) prevents the development of overt CMV disease [2,5] . However, in the last decades, CMV disease in immunocompetent patients has been increasing, with more involvement of the upper gastrointestinal tract [2,7,8,10,12] . Critically ill patients, particularly those with sepsis and under mechanical ventilation, have been proposed as being at risk for this increasing incidence because of a transiently suppressed immunity [5,13] .…”

mentioning

confidence: 99%

Cytomegalovirus Disease of the Upper Gastrointestinal Tract: An Emerging Infection in Immunocompetent Hosts

Gravito-Soares¹,

Almeida²

2017

GE Port J Gastroenterol

View full text Add to dashboard Cite

Human cytomegalovirus infection of the gastrointestinal tract in apparently immunocompetent patients

Cited by 43 publications

References 26 publications

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice

Distal Cholangiocarcinoma Associated with Papillitis with Viral CMV Inclusions

Cytomegalovirus Disease of the Upper Gastrointestinal Tract: An Emerging Infection in Immunocompetent Hosts

Contact Info

Product

Resources

About