2023
DOI: 10.1002/jmv.28574
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Human cytomegalovirus infection perturbs neural progenitor cell fate via the expression of viral microRNAs

Abstract: Human cytomegalovirus (HCMV) preferentially targets neural progenitor cells (NPCs) in congenitally infected fetal brains, inducing neurodevelopmental disorders. While HCMV expresses several microRNAs (miRNAs) during infection, their roles in NPC infection are unclear. Here, we characterized expression of cellular and viral miRNAs in HCMV‐infected NPCs during early infection by microarray and identified seven differentially expressed cellular miRNAs and six significantly upregulated HCMV miRNAs. Deep learning a… Show more

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Cited by 4 publications
(3 citation statements)
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“…Changes in miRNA expression may reflect impaired neurodevelopment. Recently, Jiang et al 21 characterized cellular and viral miRNA expression during CMV infection in neural progenitor cells. In their study, of the seven differentially expressed cellular miRNAs, miR-1246 was upregulated in CMV-infected cells; miR-1246 was also upregulated in the ScCMV group (FDR-adjusted p = 0.01, fold-change = 10.96) and included in the top-50 significantly differentially expressed miRNAs in our study.…”
Section: Discussionmentioning
confidence: 99%
“…Changes in miRNA expression may reflect impaired neurodevelopment. Recently, Jiang et al 21 characterized cellular and viral miRNA expression during CMV infection in neural progenitor cells. In their study, of the seven differentially expressed cellular miRNAs, miR-1246 was upregulated in CMV-infected cells; miR-1246 was also upregulated in the ScCMV group (FDR-adjusted p = 0.01, fold-change = 10.96) and included in the top-50 significantly differentially expressed miRNAs in our study.…”
Section: Discussionmentioning
confidence: 99%
“…One such host factors are miRNAs. These small non-coding RNAs have an important role in fine tuning the gene expression in NSCs during neurotropic viral infections ( 40 42 ). Previous reports by our group have established how NSC fate determination and self-renewal capacity are abrogated during JEV infection and how abundance of certain host miRNAs was getting affected post JEV infection in NSCs ( 24 , 35 ).…”
Section: Discussionmentioning
confidence: 99%
“…MiRNAs are an evolutionarily conserved set of small non-coding RNAs of approximately 18-22 nucleotides, and display their functions mainly via binding to the 3′ untranslated regions leading to degradation or post-transcriptional repression of the mRNA targets ( 17 ). Studies have previously implicated the essential regulatory roles of miRNAs in diverse biological or pathological processes, including tumor metastasis, cellular differentiation, proliferation, apoptosis, and tissue development ( 18 20 ). The pivotal roles of miRNAs in osteogenesis, such as osteoblast differentiation, angiogenesis, and intra-chondral bone formation have also been identified ( 21 23 ).…”
Section: Introductionmentioning
confidence: 99%