Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection

Rhodes, Jake W.; Tong, Orion; Harman, Andrew N.; Turville, Stuart

doi:10.3389/fimmu.2019.01088

Cited by 93 publications

(96 citation statements)

References 262 publications

(323 reference statements)

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“…Various organs where DCs display resident immune cell functions are the skin, blood, lungs, liver, gastrointestinal (GI)-tract, kidney, spleen, and lymph node. Tissue-resident DCs contribute to the prognosis of a range of diseases, such as allergies, auto-immunities, inflammation, and cancer progression [58][59][60][61][62]. It is not only the tissue-resident population but the migratory DCs as well that contribute hugely to the overall functionality of any organ [18].…”

Section: Discussionmentioning

confidence: 99%

The Innate Immune Cell Profile of the Cornea Predicts the Onset of Ocular Surface Inflammatory Disorders

Palomar

Montolío

Cegoñino

et al. 2019

JCM

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Ocular surface inflammatory disorder (OSID) is a spectrum of disorders that have features of several etiologies whilst displaying similar phenotypic signs of ocular inflammation. They are complicated disorders with underlying mechanisms related to several autoimmune disorders, such as rheumatoid arthritis (RA), Sjögren’s syndrome, and systemic lupus erythematosus (SLE). Current literature shows the involvement of both innate and adaptive arms of the immune system in ocular surface inflammation. The ocular surface contains distinct components of the immune system in the conjunctiva and the cornea. The normal conjunctiva epithelium and sub-epithelial stroma contains resident immune cells, such as T cells, B cells (adaptive), dendritic cells, and macrophages (innate). The relative sterile environment of the cornea is achieved by the tolerogenic properties of dendritic cells in the conjunctiva, the presence of regulatory lymphocytes, and the existence of soluble immunosuppressive factors, such as the transforming growth factor (TGF)-β and macrophage migration inhibitory factors. With the presence of both innate and adaptive immune system components, it is intriguing to investigate the most important leukocyte population in the ocular surface, which is involved in immune surveillance. Our meta-analysis investigates into this with a focus on both infectious (contact lens wear, corneal graft rejection, Cytomegalovirus, keratitis, scleritis, ocular surgery) and non-infectious (dry eye disease, glaucoma, graft-vs-host disease, Sjögren’s syndrome) situations. We have found the predominance of dendritic cells in ocular surface diseases, along with the Th-related cytokines. Our goal is to improve the knowledge of immune cells in OSID and to open new dimensions in the field. The purpose of this study is not to limit ourselves in the ocular system, but to investigate the importance of dendritic cells in the disorders of other mucosal organs (e.g., lungs, gut, uterus). Holistically, we want to investigate if this is a common trend in the initiation of any disease related to the mucosal organs and find a unified therapeutic approach. In addition, we want to show the power of computational approaches to foster a collaboration between computational and biological science.

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Section: Discussionmentioning

confidence: 99%

The Innate Immune Cell Profile of the Cornea Predicts the Onset of Ocular Surface Inflammatory Disorders

Palomar

Montolío

Cegoñino

et al. 2019

JCM

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“…Expression of DC-SIGN has indeed been found on macrophages and CD14 + cells [86]. Inflammatory dendritic epidermal cells were also recognized to express DC-SIGN [60]. At the same time, DC-SIGN expression has not been found on cDCs, pDCs, LCs, or any other "typical" subset of human DCs [60,64].…”

Section: Dc-sign Receptor Targetingmentioning

confidence: 96%

“…Inflammatory dendritic epidermal cells were also recognized to express DC-SIGN [60]. At the same time, DC-SIGN expression has not been found on cDCs, pDCs, LCs, or any other "typical" subset of human DCs [60,64]. Thus, DC-SIGN should not be recognized as a pan-DC marker, but is more likely to be a macrophage marker.…”

Section: Dc-sign Receptor Targetingmentioning

confidence: 98%

“…So far, DC-SIGN has been regarded as a possible better target for DC targeting due to its pan-DC nature in humans, a notion which mistakenly arose from human moDC and mice DC studies [95]. There is growing evidence that DC-SIGN is not expressed on "typical" human DCs at all and should be considered a macrophage marker [60]. Thus, it remains unclear which immune cell population is induced upon the application of a DC-SIGN-targeting vaccine in humans, as well as DC-SIGN's fate as an APC-targeting vaccine target.…”

Section: Dc-sign Receptor Targetingmentioning

confidence: 99%

“…DEC205 is another CLR that recycles through late endosomal or lysosomal compartments, resulting in its involvement in antigen cross-presentation and suitability for in vivo antigen-targeting [97]. In contrast to MR and DC-SIGN, DEC205 expression was found on different types of human DCs, including "typical" DCs [41,60,98]. In addition, DEC205 expression was found at intermediate levels on B cells and low levels on NK and T cells [98].…”

Section: Dec205 Receptor Targetingmentioning

confidence: 99%

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Dendritic Cells in Anticancer Vaccination: Rationale for Ex Vivo Loading or In Vivo Targeting

Baldin

Savvateeva

Bazhin

et al. 2020

Cancers

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Dendritic cells (DCs) have shown great potential as a component or target in the landscape of cancer immunotherapy. Different in vivo and ex vivo strategies of DC vaccine generation with different outcomes have been proposed. Numerous clinical trials have demonstrated their efficacy and safety in cancer patients. However, there is no consensus regarding which DC-based vaccine generation method is preferable. A problem of result comparison between trials in which different DC-loading or -targeting approaches have been applied remains. The employment of different DC generation and maturation methods, antigens and administration routes from trial to trial also limits the objective comparison of DC vaccines. In the present review, we discuss different methods of DC vaccine generation. We conclude that standardized trial designs, treatment settings and outcome assessment criteria will help to determine which DC vaccine generation approach should be applied in certain cancer cases. This will result in a reduction in alternatives in the selection of preferable DC-based vaccine tactics in patient. Moreover, it has become clear that the application of a DC vaccine alone is not sufficient and combination immunotherapy with recent advances, such as immune checkpoint inhibitors, should be employed to achieve a better clinical response and outcome.

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Fasting and calorie restriction modulate age‐associated immunosenescence and inflammaging

Tizazu

2024

Aging Medicine

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Aging is a multifaceted process impacting cells, tissues, organs, and organ systems of the body. Like other systems, aging affects both the adaptive and the innate components of the immune system, a phenomenon known as immunosenescence. The deregulation of the immune system puts elderly individuals at higher risk of infection, lower response to vaccines, and increased incidence of cancer. In the Western world, overnutrition has increased the incidence of obesity (linked with chronic inflammation) which increases the risk of metabolic syndrome, cardiovascular disease, and cancer. Aging is also associated with inflammaging a sterile chronic inflammation that predisposes individuals to age‐associated disease. Genetic manipulation of the nutrient‐sensing pathway, fasting, and calorie restriction (CR) has been shown to increase the lifespan of model organisms. As well in humans, fasting and CR have also been shown to improve different health parameters. Yet the direct effect of fasting and CR on the aging immune system needs to be further explored. Identifying the effect of fasting and CR on the immune system and how it modulates different parameters of immunosenescence could be important in designing pharmacological or nutritional interventions that slow or revert immunosenescence and strengthen the immune system of elderly individuals. Furthermore, clinical intervention can also be planned, by incorporating fasting or CR with medication, chemotherapy, and vaccination regimes. This review discusses age‐associated changes in the immune system and how these changes are modified by fasting and CR which add information on interventions that promote healthy aging and longevity in the growing aging population.

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Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection

Cited by 93 publications

References 262 publications

The Innate Immune Cell Profile of the Cornea Predicts the Onset of Ocular Surface Inflammatory Disorders

The Innate Immune Cell Profile of the Cornea Predicts the Onset of Ocular Surface Inflammatory Disorders

Dendritic Cells in Anticancer Vaccination: Rationale for Ex Vivo Loading or In Vivo Targeting

Fasting and calorie restriction modulate age‐associated immunosenescence and inflammaging

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