Human DHRS7, promising enzyme in metabolism of steroids and retinoids?

Štambergová, Hana; Zemanová, Lucie; Lundová, Tereza; Malčeková, B.; Skarka, Adam; Šafr, Miroslav; Wsól, Vladimı́r

doi:10.1016/j.jsbmb.2015.09.041

Cited by 22 publications

(16 citation statements)

References 49 publications

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“…DHRS7 can recognize steroids and retinoids as potential substrates, and might act a pivotal part in the metabolism of these signal molecules (Stambergova et al, 2016). Lopez et al (2015) reported that NUPR2 could induce G1 phase cell cycle arrest, decrease cell survival rate and proliferation ability.…”

Section: Discussionmentioning

confidence: 99%

Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer

Zhao

Mao

et al. 2021

PeerJ

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The members of the Nedd4-like E3 family participate in various biological processes. However, their role in clear cell renal cell carcinoma (ccRCC) is not clear. This study systematically analyzed the Nedd4-like E3 family members in ccRCC data sets from multiple publicly available databases. NEDD4L was identified as the only NEDD4 family member differentially expressed in ccRCC compared with normal samples. Bioinformatics tools were used to characterize the function of NEDD4L in ccRCC. It indicated that NEDD4L might regulate cellular energy metabolism by co-expression analysis, and subsequent gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. A prognostic model developed by the LASSO Cox regression method showed a relatively good predictive value in training and testing data sets. The result revealed that NEDD4L was associated with biosynthesis and metabolism of ccRCC. Since NEDD4L is downregulated and dysregulation of metabolism is involved in tumor progression, NEDD4L might be a potential therapeutic target in ccRCC.

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Section: Discussionmentioning

confidence: 99%

Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer

Zhao

Mao

et al. 2021

PeerJ

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“…The reduction of retinal is mediated by other enzymes including AKRs (1B1, 1B15, 1C3 and 1C4), retinol dehydrogenases (RDHs) and dehydrogenase/reductase (SDR family) members (DHRSs). The k cat / K m value for retinal (45 min −1 μM −1 ) of AKR1B10 is much higher than those (0.14–5.3 min −1 μM −1 ) of the other AKRs [ 5 , 34 ], DHRS4 [ 36 ], DHRS7 [ 37 ], and RDH13 [ 38 ], although its K m value for retinal (0.6 μM) is higher than those of RDH11, RDH12 and RDH14 (0.04–0.15 μM) [ 38 ] and DHRS3 [ 39 ]. In addition, the K m and k cat / K m values of AKR1B10 are much lower and higher, respectively, than K m (2.4–11 μM) and k cat / K m values (1.6–7.6 min −1 μM −1 ) of aldehyde dehydrogenases (ALDHs: 1A1, 1A2 and 1A3) [ 40 ], which catalyze the oxidation of retinal to retinoic acid.…”

Section: Akr1b10 As a Multifunctional Nadph-dependent Reductasementioning

confidence: 99%

The Role of AKR1B10 in Physiology and Pathophysiology

2021

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AKR1B10 is a human nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase belonging to the aldo-keto reductase (AKR) 1B subfamily. It catalyzes the reduction of aldehydes, some ketones and quinones, and interacts with acetyl-CoA carboxylase and heat shock protein 90α. The enzyme is highly expressed in epithelial cells of the stomach and intestine, but down-regulated in gastrointestinal cancers and inflammatory bowel diseases. In contrast, AKR1B10 expression is low in other tissues, where the enzyme is upregulated in cancers, as well as in non-alcoholic fatty liver disease and several skin diseases. In addition, the enzyme’s expression is elevated in cancer cells resistant to clinical anti-cancer drugs. Thus, growing evidence supports AKR1B10 as a potential target for diagnosing and treating these diseases. Herein, we reviewed the literature on the roles of AKR1B10 in a healthy gastrointestinal tract, the development and progression of cancers and acquired chemoresistance, in addition to its gene regulation, functions, and inhibitors.

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“…The prediction model developed in this study showed that DHRS7, NUPR2, C4orf19, CDKL2, SOWAHB, WDR72, EPB41L4A_DT, and IRF6 were significantly associated with NEDD4L function. DHRS7 can recognize steroids and retinoids as potential substrates, and might act a pivotal part in the metabolism of these signal molecules (Stambergova et al, 2016). Lopez et al reported that NUPR2 could induce G1 phase cell cycle arrest, decrease cell survival rate and proliferation ability (Lopez et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Peer Review #1 of "Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer (v0.2)"

2021

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Human DHRS7, promising enzyme in metabolism of steroids and retinoids?

Cited by 22 publications

References 49 publications

Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer

Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer

The Role of AKR1B10 in Physiology and Pathophysiology

Peer Review #1 of "Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer (v0.2)"

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