2015
DOI: 10.1016/j.bbrc.2014.12.032
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Human DNA methyltransferase gene-transformed yeasts display an inducible flocculation inhibited by 5-aza-2′-deoxycytidine

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Cited by 12 publications
(6 citation statements)
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“…There are several shreds of evidence which suggest that the mechanism of flocculation/filamentous growth is functionally conserved. First, the expression of certain human genes such as DNA methyltransferase 1 ( DNMT1 ) has been reported to induce yeast flocculation (Sugiyama et al , ). Second, most of the yeast cell wall flocculins and human cell membrane adhesins consist of amyloid forming amino acid sequences (Ramsook et al , ; Rameau et al , ).…”
Section: Discussionmentioning
confidence: 99%
“…There are several shreds of evidence which suggest that the mechanism of flocculation/filamentous growth is functionally conserved. First, the expression of certain human genes such as DNA methyltransferase 1 ( DNMT1 ) has been reported to induce yeast flocculation (Sugiyama et al , ). Second, most of the yeast cell wall flocculins and human cell membrane adhesins consist of amyloid forming amino acid sequences (Ramsook et al , ; Rameau et al , ).…”
Section: Discussionmentioning
confidence: 99%
“…DNMT1 is the most abundant DNA methyltransferase in mammalian cells and plays a crucial role in maintaining the methylation status of DNA during subsequent cell divisions during development by adding methyl groups to hemimethylated CpG dinucleotides in the newly synthesized DNA strand. Accumulating data suggest that changes in the DNA methylation status are closely related to DNMT1 expression [Leppert and Matarazzo, ; Newman et al, ; Sugiyama et al, ]. In addition, histone methylations are catalyzed by a group of histone methyltransferases, such as EZH2, which can promote H3K27 methylation [Christofides et al, ].…”
Section: Discussionmentioning
confidence: 99%
“…There are evidences which suggest that the mechanism of flocculation/filamentous growth is functionally conserved. First; the expression of certain human genes such as DNA methyltransferase 1 (DNMT1) has been reported to induce yeast flocculation (SUGIYAMA et al 2015). Second; the expression of an activated extracellular signal-regulated kinase 1 (ERK1), one of the MAP kinases of mammalian systems in yeast has been shown to induce filamentous growth and cell wall remodeling (ATIENZA et al 2000).…”
Section: The Yeast Flocculation Is Regulated Through a Conserved Map mentioning
confidence: 99%