Human early pregnancy factor: serum concentrations before and after therapeutic abortion in comparison with ?-hCG and an early pregnancy associated protein

Straube, W; Hübel, V; Loh, Marie; Leipe, S

doi:10.1007/bf00934128

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…Our results support the statements of Straube et al [ 18] and Hubei et al [8] and indicate that estimation of EPF could be of prognostic value in early pregnancy presenting with vaginal bleeding as suggested by Gerhard et al [19],…”

Section: Resultssupporting

confidence: 82%

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Early Pregnancy Factor as a Marker for Assessing Embryonic Viability in Threatened and Missed Abortions

Shahani¹,

Moniz²,

Bordekar³

et al. 1994

Gynecol Obstet Invest

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It is now well recognized that the presence of early pregnancy factor (EPF) can signify the occurrence of fertilization, continuation of pregnancy and the existence of a viable embryo. With this in view, a study was undertaken to observe the potential of EPF as a marker in assessing embryo viability in cases complicated with vaginal bleeding during early pregnancy. The results indicated that the sensitivity of EPF as a marker in predicting threatened or missed abortion was 78.9% and the specificity 95.6%. The positive predictive value was observed to be 93.8% and the negative predictive value 84.6%. Our studies have shown that since EPF is present in viable but absent in non-viable pregnancies, it could be a useful marker of prognostic value in threatened abortions.

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Section: Resultssupporting

confidence: 82%

“…Straube et al [ 18] have suggested that since EPF is the most sensitive parameter for the surveillance of early pregnancy, any disturbance of early pregnancy could be indicated by EPF estimations earlier than with commonly used hormones and sonographic determinations.…”

Section: Resultsmentioning

confidence: 99%

Early Pregnancy Factor as a Marker for Assessing Embryonic Viability in Threatened and Missed Abortions

Shahani¹,

Moniz²,

Bordekar³

et al. 1994

Gynecol Obstet Invest

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“…imminent abortion, missed abortion, ectopic pregnancy) show often a reduced serum EPF activity. Furthermore, after the death or loss of conceptus, EPF is no longer detectable in serum (Koch et al, 1982;Rolfe, 1982;Qin-Zheng, 1987;Sueoka et al, 1988;Straube et al, 1989). In human after therapeutic abortion, disappearance of EPF is indeed the earliest marker of embryonic loss (Mettler et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Early Pregnancy Factor (EPF) as a Marker for the Diagnosis of Subclinical Embryonic Loss

Shahani

Moniz²,

Chitlange³

et al. 2009

Exp Clin Endocrinol Diabetes

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The validation of EPF as a possible correlate of early fertilization has made it possible to study and detect fertilization of the ovum in normal fertile women (during the luteal phase) and also in women with infertility, where the fertilization of the ovum may not be affected but there may be impairment in early embryonic development which results in early embryo loss or subclinical embryo loss. Our results have suggested that using EPF as a marker, we could detect subclinical embryonic loss in 57.8% of the infertile women where more than one menstrual cycle was studied and the blood was collected 4-7 days after ovulation. After the missed period, 80% of the patients who were negative for EPF but positive for hCG had spontaneous abortions. It would be interesting to study how EPF behaves as a marker, to detect subclinical embryonic loss in diverse pathological situations such as recurrent abortions, parental age and translocation carrier parents.

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Mechanism of Action of Levonorgestrel Emergency Contraception

Kahlenborn¹,

Peck

Severs

2015

Linacre Q

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There has been much debate regarding levonorgestrel emergency contraception's (LNG-EC's) method of action since 1999 when the Food and Drug Administration first approved its use. Proponents of LNG-EC have argued that they have moral certitude that LNG-EC works via a non-abortifacient mechanism of action, and claim that all the major scientific and medical data consistently support this hypothesis. However, newer medical data serve to undermine the consistency of the non-abortifacient hypothesis and instead support the hypothesis that preovulatory administration of LNG-EC has significant potential to work via abortion. The implications of the newer data have important ramifications for medical personnel, patients, and both Catholic and non-Catholic emergency room protocols. In the future, technology such as the use of early pregnancy factor may have the potential to quantify how frequently preovulatory LNG-EC works via abortion. Lay Summary: How Plan B (levonorgestrel emergency contraception) works has been vigorously debated ever since the Food and Drug Administration approved it in 1999. Many doctors and researchers claim that it has either no-or at most-an extremely small chance of working via abortion. However, the latest scientific and medical evidence now demonstrates that levonorgestrel emergency contraception theoretically works via abortion quite often. The implications of the newer data have important ramifications for medical personnel, patients, and both Catholic and non-Catholic emergency room rape protocols.

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Human early pregnancy factor: serum concentrations before and after therapeutic abortion in comparison with ?-hCG and an early pregnancy associated protein

Cited by 3 publications

References 7 publications

Early Pregnancy Factor as a Marker for Assessing Embryonic Viability in Threatened and Missed Abortions

Early Pregnancy Factor as a Marker for Assessing Embryonic Viability in Threatened and Missed Abortions

Early Pregnancy Factor (EPF) as a Marker for the Diagnosis of Subclinical Embryonic Loss

Mechanism of Action of Levonorgestrel Emergency Contraception

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